Article
Public, Environmental & Occupational Health
Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, Alessandra Renieri, Sara Amitrano, Sirui Zhou, Yiheng Chen, Vincenzo Forgetta, J. Brent Richards
Summary: Mendelian randomization using genetic determinants of serum-ACE levels found no association between genetically decreased ACE levels and susceptibility to, or severity of, COVID-19, suggesting that individuals taking ACE inhibitors should not discontinue therapy during the pandemic.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Food Science & Technology
Mingzhe Ma, Yinghui Feng, Yulu Miao, Qiang Shen, Shuting Tang, Juan Dong, John Z. H. Zhang, Lujia Zhang
Summary: Chronic diseases, such as hypertension, have detrimental effects on human health. Conventional drugs for treatment often come with significant side effects. Food-sourced ACE inhibitory peptides provide a safer alternative, with fewer side effects. However, the lack of a systematic and effective screening method and understanding of the sequence characteristics and molecular mechanisms hinder the development of ACE inhibitory peptides.
Article
Chemistry, Multidisciplinary
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: Bioactive peptides were successfully produced from fish and beef skeletal muscles, showing antioxidant, angiotensin-converting enzyme inhibitory, and antimicrobial activities after hydrolysis and purification.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Zhipeng Yu, Li Wang, Sijia Wu, Wenjun Xue, Wenzhu Zhao, Jianrong Li
Summary: This study used a non-targeted metabolomics approach to investigate the anti-hypertensive effects of RVPSL on SHRs. The results suggested that RVPSL potentially alleviated hypertension in SHRs mainly through integrated regulations of metabolism and production of specific metabolites.
Correction
Biochemistry & Molecular Biology
Qudsia Yousafi, Jannat Batool, Muhammad Saad Khan, Tamsila Perveen, Muhammad Wasim Sajid, Abrar Hussain, Asim Mehmood, Shahzad Saleem
Summary: The co-author's name was misspelled in the original version of the article.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Review
Nutrition & Dietetics
Nancy Auestad, Donald K. Layman
Summary: Milk proteins are known for their high nutritional quality due to their essential amino acid composition and various bioactivities, and can be easily separated into casein and whey fractions. Encrypted peptides in these proteins are increasingly recognized as beneficial biologically active metabolites for human health.
Article
Biochemistry & Molecular Biology
Cheng-Cheng Song, Bian-Wen Qiao, Qin Zhang, Chen-Xin Wang, Ying-Huan Fu, Bei-Wei Zhu
Summary: This study investigated the selective inhibition of food-derived tyrosine dipeptides on the ACE domain, providing a potential new approach for antihypertensive drug development with fewer side effects. The results showed that certain dipeptides exhibited competitive and noncompetitive inhibition patterns on the C-domain of ACE, highlighting the potential of these compounds as antihypertensive peptides. Further understanding the structure-activity relationship between inhibitors and ACE domain may contribute to the development of novel antihypertensive therapies.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Emergency Medicine
Steven Rosenbaum, R. Gentry Wilkerson, Michael E. Winters, Gary M. Vilke, Marie Yung Chen
Summary: Angioedema induced by ACE inhibitors is a complex complication that may lead to airway compromise. The optimal treatment remains uncertain, with discontinuation of ACE inhibitors being the primary focus of management.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Biology
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: This study purified and characterized bioactive peptides with inhibitory action on ACE, antimicrobial and antioxidant properties from frozen chicken breast. Chicken hydrolysate showed potential as a natural preservative by reducing bacterial growth and lipid oxidation in chicken breast.
Article
Food Science & Technology
Talita C. E. S. Nascimento, Joao Vitor Dutra Molino, Priscila R. S. Donado, Gualberto S. A. Montalvo, Wellington L. dos Santos, Jose Erick G. Gomes, Joao H. P. M. Santos, Roberto da Silva, Lara Duraes Sette, Adalberto Pessoa Junior, Keila Aparecida Moreira
Summary: The extracellular serine protease produced by Acremonium sp. L1-4B isolated from the Antarctic continent was used to hydrolyze bovine and caprine sodium caseinate, resulting in protein hydrolysates with antioxidant and antihypertensive potential. Mass spectrometry characterization revealed differences in peptide sequences between the bovine and caprine hydrolysates, indicating the potential for developing new functional foods and nutraceutical formulations.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Plant Sciences
Na Thi Ty Ngo, Tharindu R. L. Senadheera, Fereidoon Shahidi
Summary: This study investigated the protein hydrolysates from sophia and camelina and found that they exhibited high antioxidant activity and released potential DPP IV and ACE inhibitory peptides. The integrated analysis using in vitro and in silico methods suggested that these hydrolysates could be promising candidates for functional foods, nutraceuticals, and natural therapeutics.
Article
Biochemistry & Molecular Biology
Xin-Xin Han, Yun-Qin Jia, Chun-Yu Liu, Hao-Yu Wang, Zhen-Yuan Zhu
Summary: In this study, three novel ACE-inhibitory peptides were prepared from Small-Aroma Chicken breast and showed significant inhibitory activity. The mechanism of inhibition and binding free energies were also investigated.
PROCESS BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Agriculture, Multidisciplinary
Jana Rueckriemen, Uwe Schwarzenbolz, Simone Adam, Thomas Henle
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Article
Chemistry, Applied
Jana Rueckriemen, Oliver Klemm, Thomas Henle
Article
Food Science & Technology
Jana Rueckriemen, Christoph Hohmann, Michael Hellwig, Thomas Henle
FOOD RESEARCH INTERNATIONAL
(2017)
Article
Agriculture, Multidisciplinary
Michael Hellwig, Jana Rueckriemen, Daniel Sandner, Thomas Henle
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Food Science & Technology
Jana Rueckriemen, Thomas Henle
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2018)
Article
Food Science & Technology
Jana Rueckriemen, Anne Hellwig, Stephanie Schultes, Michael Hellwig, Friederike Hahne, Thomas Henle
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2018)
Article
Endocrinology & Metabolism
Richard Kehm, Jana Rueckriemen, Daniela Weber, Stefanie Deubel, Tilman Grune, Annika Hoehn
NUTRITION & DIABETES
(2019)
Article
Biochemistry & Molecular Biology
Jana Raupbach, Christiane Ott, Jeannette Koenig, Tilman Grune
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Amit Sharma, Daniela Weber, Jana Raupbach, Tikam Chand Dakal, Klaus Fliessbach, Alfredo Ramirez, Tilman Grune, Ullrich Wuellner
Article
Chemistry, Applied
Hannah E. Zenker, Jana Raupbach, Sjef Boeren, Harry J. Wichers, Kasper A. Hettinga
FOOD HYDROCOLLOIDS
(2020)
Article
Biochemistry & Molecular Biology
Richard Kehm, Tim Baldensperger, Jana Raupbach, Annika Hoehn
Summary: Generation of reactive oxygen species and related oxidants during life processes can lead to irreversible modifications of proteins, potentially contributing to pathological conditions and diseases.
Article
Geriatrics & Gerontology
Catrin Herpich, Bastian Kochlik, Daniela Weber, Christiane Ott, Tilman Grune, Kristina Norman, Jana Raupbach
Summary: Dicarbonyl stress, characterized by increased formation of 1,2-dicarbonyl compounds, is associated with age-related pathologies. However, aging does not necessarily result in dicarbonyl stress, as demonstrated in studies involving older mice and human subjects. In women, age did not affect fasting 1,2-dicarbonyl concentrations or their response to an oral glucose challenge. In men, fasting methylglyoxal (MGO) was higher in older individuals, but no age differences were found for fasting 3-deoxyglucosone (3-DG) and glyoxal (GO) concentrations. Older individuals had higher glucose and insulin response, but this did not translate into a higher response in 1,2-dicarbonyl compounds. Overall, strategies to cope with 1,2-dicarbonyl formation may remain intact during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Holger Hoffmann, Christiane Ott, Jana Raupbach, Lars Andernach, Matthias Renz, Tilman Grune, Franziska S. Hanschen
Summary: Thermal glucosinolate degradation products, specifically 3-alk(en)yl-4-hydroxythiazolidine-2-thiones, were found to be formed during the boiling of cabbage and can be absorbed by the human body via passive diffusion. These compounds showed no acute cell toxicity and no significant changes in antioxidant potential or NAD(P)H dehydrogenase quinone 1 (NQO1) activity. However, they exhibited a certain degree of inhibition on glycogen synthase kinases-3 (GSK-3). This study did not find any health-promoting or toxic effects of these degradation products.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Jana Raupbach, Stephan K. Mueller, Vanessa Schnell, Suse Friedrich, Anne Hellwig, Tilman Grune, Thomas Henle
Summary: This study investigates the effect of individual lysine modifications in free form or bound to casein on human colon cancer cells. The results show that modified casein containing protein-bound pyrraline activates Nrf2, while FL or CML have no effect on NF-κB activation. This suggests that studies on the biological effects of glycated proteins require an individual consideration of defined structures.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.