Modulation of BACE1 Activity by Chemically Modified Aptamers

Whole cell-SELEX of aptamers with a tyrosine-like side chain against live bacteria

(2017) Marleen Renders et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection

(2017) Yajun Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair

(2017) E. Eremeeva et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selection of DNA aptamers with two modified bases

(2017) Bharat N. Gawande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Morphing of DNA Containing Four Noncanonical Bases

(2016) Elena Eremeeva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

(2016) Farhana Lipi et al.   RNA Biology

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

pH-Dependent Population Shift Regulates BACE1 Activity and Inhibition

(2015) Christopher R. Ellis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of Aptamers with an Expanded Chemical Repertoire

(2015) Stella Diafa et al.   MOLECULES

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

A semi-synthetic organism with an expanded genetic alphabet

(2014) Denis A. Malyshev et al.   NATURE

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Lilly buys back into the BACE race for Alzheimer's disease

(2014) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

Aptamers Act as Activators for the Thrombin Mediated-Hydrolysis of Peptide Substrates

(2013) Xiaohong Tan et al.   CHEMBIOCHEM

Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA

(2013) J. Sebastian Temme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

In vitro selection with artificial expanded genetic information systems

(2013) K. Sefah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of different methods for generation of single-stranded DNA for SELEX processes

(2012) M. Svobodová et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Assessing the biocompatibility of click-linked DNA in Escherichia coli

(2012) A. Pia Sanzone et al.   NUCLEIC ACIDS RESEARCH

Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs

(2012) Amritraj Patra et al.   NUCLEIC ACIDS RESEARCH

Multivalent Glycocluster Design through Directed Evolution

(2011) Iain S. MacPherson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Evolution of a Bacterium’s Genome

(2011) Philippe Marlière et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of β-Secretasein Vivovia Antibody Binding to Unique Loops (D and F) of BACE1

(2011) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

(2011) A. H. El-Sagheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymerase Incorporation and Miscoding Properties of 5-Chlorouracil

(2010) Cherine H. Kim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Conditions optimized for the preparation of single-stranded DNA (ssDNA) employing lambda exonuclease digestion in generating DNA aptamer

(2010) Marimuthu Citartan et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

A DNAzyme with Three Protein-Like Functional Groups: Enhancing Catalytic Efficiency of M2+-Independent RNA Cleavage

(2009) Marcel Hollenstein et al.   CHEMBIOCHEM

An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor

(2009) Jens Müller et al.   CHEMISTRY & BIOLOGY

Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus

(2009) Xiaoxiao Cao et al.   NUCLEIC ACIDS RESEARCH

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Streptavidin-Coated Magnetic Beads for DNA Strand Separation Implicate a Multitude of Problems During Cell-SELEX

(2009) Angela Paul et al.   OLIGONUCLEOTIDES

Enrichment of Cell‐Targeting and Population‐Specific Aptamers by Fluorescence‐Activated Cell Sorting

(2008) Marie‐Sophie L. Raddatz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid   Protein Production

(2008) H. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY