The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

(2017) Laura Osgerby et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma

(2016) K. Satoh et al.   CLINICAL CANCER RESEARCH

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

(2015) A. Kazlauskaite et al.   EMBO REPORTS

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

(2014) Agne Kazlauskaite et al.   FEBS Journal

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

(2014) Tinghong Ye et al.   PLoS One

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

PINK1 rendered temperature sensitive by disease-associated and engineered mutations

(2013) D. P. Narendra et al.   HUMAN MOLECULAR GENETICS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Cytometric assessment of mitochondria using fluorescent probes

(2011) Cécile Cottet-Rousselle et al.   CYTOMETRY PART A

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

(2011) F L Khanim et al.   Blood Cancer Journal

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

(2011) H. I. Woodroof et al.   Open Biology

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

(2009) Zhenyu Yue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS