4.7 Article

Novel micro/nanostructured TiO2/ZnO coating with antibacterial capacity and cytocompatibility

期刊

CERAMICS INTERNATIONAL
卷 44, 期 8, 页码 9711-9719

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2018.02.202

关键词

TiO2; ZnO; Surfaces; Biomedical applications

资金

  1. National Natural Science Foundation of China [U1605243, 51472139, 31600763]
  2. International S&T Cooperation of the Ministry of Science and Technology of China [2015DFG52490]

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Insufficient osseointegration between implants and bone, and peri-implant infection are the two most common factors contributing to implantation failure. As such, implant materials should ideally be designed with antibacterial capacity while maintaining cytocompatibility. Combining Zn, a known antibacterial agent, with micro/nanostructures on the implant surface to promote osseointegration, potentially reduces peri-implant infection. To this end, in the present study, we developed novel bifunctional micro/nanostructured titanium oxide/zinc oxide (TiO2/ZnO) coating by micro-arc oxidation (MAO) followed by hydrothermal treatment. The release rate of the Zn2+ ions was reduced by heat treatment which established a balance between antibacterial capacity and cytocompatibility. The results demonstrate a simple approach for developing a Zn-based material that balances antibacterial capacity and cytocompatibility as a promising coating material for Ti implants.

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