Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Review
Cell Biology
Xinyun Xu, Ling Zhao, Paul D. Terry, Jiangang Chen
Summary: Mesenchymal stem cells from bone marrow can differentiate into either adipocytes or osteoblasts, and external stimuli such as environmental contaminants, heavy metals, dietary, and physical factors can influence this fate decision. Maintaining a balance between osteogenesis and adipogenesis is crucial for bone homeostasis, and disruptions in lineage commitment of these stem cells are associated with various bone disorders. This review focuses on understanding how external stimuli affect the fate of mesenchymal stem cells and calls for future studies to investigate the impact on bone health and underlying mechanisms of differentiation.
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Meng Li, Jing Wu, Wenbo Geng, Yulu Yang, Xuan Li, Kun Xu, Ke Li, Yan Li, Qiaojian Duan, Pengfei Gao, Kaiyong Cai
Summary: Localized corrosion of 316L stainless steel reduces the viability, adhesion, proliferation, and osteogenic differentiation abilities of BMSCs. It causes cytotoxicity through the release of metallic ions and generates reactive oxygen species (ROS) around the corrosion pits, leading to oxidative stress and cell membrane depolarization. This study provides insights into corrosion-mediated degradation of cell function and material-cell interactions.
Review
Cell & Tissue Engineering
Chuan Qin, Lin Bai, Yongning Li, Kewei Wang
Summary: Transplantation of bone marrow-derived mesenchymal stem cells can alleviate neuropathology and cognitive deficits in Alzheimer's disease models by activating autophagy and apoptosis pathways, inhibiting protein aggregation and neuroinflammation, and promoting synaptogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tongtong Chen, Hanqi Wang, Chaoyin Jiang, Yong Lu
Summary: This study reveals that under oxidative stress conditions, PKD1 may alleviate the inhibitory effect of oxidative stress on osteogenesis of rat BM-MSCs through TAZ activation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Cell Biology
Jing Wang, Yi Zhang, Jin Cao, Yi Wang, Nadia Anwar, Zihan Zhang, Dingmei Zhang, Yaping Ma, Yin Xiao, Lan Xiao, Xin Wang
Summary: The skeletal system is crucial for muscle attachment, organ protection, mineral storage, hematopoiesis, and participation in the endocrine and immune system. Autophagy plays a vital role in bone regeneration by controlling molecular degradation and organelle renewal. Autophagy is involved in various bone diseases and can be modulated through autophagy regulators and the use of biomaterials. Understanding autophagy in bone diseases has significant clinical implications.
Article
Environmental Sciences
Hongping Gu, Jinrong Li, Yuehan Ni
Summary: This study investigates the therapeutic effect of sinomenine on renal fibrosis and its mechanism. The results show that sinomenine can improve the progression of renal fibrosis by regulating the expression of miR-204-5p in exosomes from bone marrow mesenchymal stem cells and the PI3K-AKT pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Qiuyan Zhao, Changfu Hao, Jingjing Wei, Ruoxuan Huang, Chao Li, Wu Yao
Summary: BMSCs were found to significantly reduce lung inflammation, collagen deposition, and the production of fibronectin, primarily through the inhibition of apoptosis and pyroptosis rather than autophagy. This provides a new insight into the treatment of lung fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Biomedical
Pingping Yuan, Zhiye Li, Bo Shao, Tian Zeng, Xiaopeng Wu, Yinggang Wang, Yimin Zhao, Wei Wu
Summary: In this study, BMSCs pre-conditioned in a starving environment were found to enhance the anti-apoptosis potential of co-transplanted chondrocytes, and extracellular vesicles derived from starving BMSCs played essential roles in improving apoptosis and regulating autophagy of chondrocytes. In vivo studies confirmed that these EVs significantly improved the survival of chondrocyte bricks.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Qing Zhao, Xinran Liu, Chuanying Yu, Yu Xiao
Summary: This review provides a deep insight into the synergistic performance of BMSCs and macrophages in fracture healing, discussing their respective functions, relevant impact factors, and mechanisms. It aims to offer valuable cues and technical support for research on macrophage- and BMSC-related treatments, such as combined cell therapy for bone fractures.
DNA AND CELL BIOLOGY
(2022)
Article
Critical Care Medicine
Meng Deng, Jing He, Changfu Hao, Yonghua Guo, Huifang Si, Xuedan Deng, Chengpeng Zhang, Shiyu Li, Sanqiao Yao, Wenjie Ren, Wu Yao
Summary: This study investigates the effect of bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs (BMSCs-Exo) on blast lung injuries (BLIs) caused by gas explosion in rats. The findings demonstrate that BMSCs and BMSCs-Exo significantly reduce oxidative stress and inflammatory infiltration in the lungs. Additionally, they regulate apoptosis, autophagy, and pyroptosis, suggesting their potential in attenuating BLI.
Article
Biotechnology & Applied Microbiology
Pascal Fichtel, Malte von Bonin, Robert Kuhnert, Kristin Moebus, Martin Bornhaeuser, Manja Wobus
Summary: Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis.
The communication between HSPCs and MSCs is mediated by direct cell-cell contacts or extracellular vesicles (EVs) that carry bioactive substances. Aging MSCs secrete fewer miRNAs, but aged MSC-EVs contain higher levels of specific miRNAs such as miR-29a and miR-34a. Young EVs enhance the cell number and viability of HSPCs, while aged MSC-EVs promote the differentiation of HSPCs into erythroid and erythroid-megakaryocytic progenitor cells. The therapeutic relevance of MSC-derived EVs in modulating HSPC characteristics needs further investigation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Zhibiao Bai, Kai Hu, Zeyu Shou, Han Zhou, Jiahuan Yu, Hongming Meng, Liangyan Chen, Tiantian Yu, Ruofei Lu, Na Li, Chun Chen
Summary: This study investigated the effect of PC/Mucin multilayers on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The results showed that PC/Mucin multilayers promoted the differentiation of BMSCs into osteoblasts and this effect was mediated by the activation of the Wnt/β-catenin pathway. These findings have important implications for the development of materials and coatings for bone regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Applied
A. M. Hezma, Tarek A. Elkhooly, Gamal S. El-Bahy
JOURNAL OF POROUS MATERIALS
(2020)
Letter
Oncology
Xujie Liu, Amita M. Vaidya, Da Sun, Yan Zhang, Nadia Ayat, Andrew Schilb, Zheng-Rong Lu
CANCER COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Zhaozhen Wang, Xujie Liu, Vidmi Taolam Martin, Mohamed Abdullahi Abdi, Lijun Chen, Yong Gong, Yiran Yan, Liming Song, Zhongxun Liu, Xianliao Zhang, Yan Chen, Bo Yu
JOURNAL OF NANOMATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Xujie Liu, Xiaoning Li, Ranran Zhang, Liping Wang, Qingling Feng
Summary: Dual microspheres based on thiolated chitosan (CS-TBA)/CaCO3 were fabricated by ionic gelation method, combining the benefits of CS-TBA for improved water solubility and CaCO3 for mesoporous structure, showing controlled drug release in vitro and having potential applications in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Wangqing Bian, Zhenxing Pan, Yakun Wang, Wei Long, Zefeng Chen, Niping Chen, Yaoxun Zeng, Jiongpeng Yuan, Xujie Liu, Yu-Jing Lu, Yan He, Kun Zhang
Summary: The study demonstrated the significant effectiveness of thiazole orange-based Mito-BWQ in tumor treatment by generating high heat to kill cancer cells through exogenous laser irradiation.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Mostafa A. Abdelshafi, Salma M. Fathy, Tarek A. Elkhooly, Fikry M. Reicha, Manal F. Osman
Summary: By self-assembling hydroxyapatite on collagen fibers in different ratios, we can improve the micro-tensile bond strength and potentially enhance adhesion to the carious zone and its durability.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xujie Liu, Yakun Wang, Yan He, Xiaofeng Wang, Ranran Zhang, Akash Bachhuka, Rahul Madathiparambil Visalakshan, Qingling Feng, Krasimir Vasilev
Summary: The study reveals that surface chemistry and topography can synergistically influence the morphology, focal adhesion formation, and osteogenic/adipogenic differentiation of human mesenchymal stem cells. This suggests that different material properties can have a significant impact on cell response and highlights the importance of designing functional biomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Zixu Wang, Han Wang, Junjie Xiong, Jiahao Li, Xiaomin Miao, Xingzi Lan, Xujie Liu, Wenlong Wang, Nian Cai, Yadong Tang
Summary: In this study, a micro/nano hierarchical scaffold for bone tissue engineering was fabricated by combining MEW and SE techniques. The addition of gelatin nanofibers improved the hydrophilicity and slightly enhanced the mechanical strength of the scaffolds. MEW/SE composite scaffolds showed higher cell adhesion efficiency, improved cell proliferation, and higher osteoinductive ability compared to PCL MEW scaffolds.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Wenxia Wang, Tingting Chen, Zhen Li, Qiting Tan, Zhenbang Meng, Hailun Qiu, Xujie Liu, Junxia Zheng
Summary: Different types of face masks were evaluated based on multiple international standards, with folding masks showing the highest particulate filtration efficiency and cup masks having the highest respiratory resistance. Generally, masks are more likely to meet the criteria of the EN149-2001+A1:2009 standard in terms of PFE, while meeting the requirements of the GB2626-2019 and NIOSH 42 CFR Part84-2019 standards for respiratory resistance is easier.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Materials Science, Multidisciplinary
Xujie Liu, Jiongpeng Yuan, Jian Zhang, Rahul Madathiparambil Visalakshan, Wenxia Wang, Yongxiao Xiang, Yan He, Qingling Feng, Krasimir Vasilev
Summary: The plasma deposited polyoxazoline (PPOx) with surface nanotopography gradient showed suppressed adhesion of S. aureus and enhanced initial attachment and spreading of hMSCs, as well as promoted osteogenic differentiation of hMSCs. The RhoA/ROCK signaling pathway may be involved in the enhancement of osteoinductive capacity of PPOx surface by nanotopography.
Article
Engineering, Biomedical
Zefeng Chen, Yaoxun Zeng, Niping Chen, Mingxia Zhang, Yakun Wang, Zhenxing Pan, Jiongpeng Yuan, Zhaoyi Ye, Xiaojing Li, Wangqing Bian, Haihong Li, Kun Zhang, Yan He, Xujie Liu
Summary: This study proposes a novel approach for the transport of metal ions using polyethylene glycol. By a simple synthesis method, 31 different metal ion-based nanoparticles were successfully synthesized and demonstrated their potential for cancer theranostics.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Wangqing Bian, Yakun Wang, Zhenxing Pan, Niping Chen, Xiaojing Li, Wing-Leung Wong, Xujie Liu, Yan He, Kun Zhang, Yu-Jing Lu
Summary: Photothermal therapy (PTT) is a promising approach for cancer treatment, with the potential to reduce the adverse effects of traditional chemotherapy. Recent research highlights the application of functionalized nanomaterials in PTT and combined therapies, offering new insights for future disease treatment.
ACS APPLIED NANO MATERIALS
(2021)
Article
Infectious Diseases
Reham M. Goda, Ahmed M. El-Baz, Eman M. Khalaf, Nada K. Alharbi, Tarek A. Elkhooly, Mohamed M. Shohayeb
Summary: This study successfully inhibited bacterial colonization on urinary tract catheters by coating them with silver nanoparticles. The silver nanoparticles significantly inhibited the colonization of antibiotic-resistant clinical bacteria and showed stronger antibacterial effects against Gram-negative bacteria.
Article
Biotechnology & Applied Microbiology
Mostafa Mabrouk, Tarek A. Elkhooly, Shaimaa K. Amer
Summary: This research investigated the influence of different Actinomycete strains on the properties of silver nanoparticles, finding that Streptomyces spiralis and Streptomyces rochei were able to produce AgNPs. The diversity and molecular weights of proteins secreted by these strains affected the polydispersity of AgNPs, highlighting the importance of biomacromolecule sizes on the physical properties of biogenic nanoparticles.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2021)
