Nanos genes and their role in development and beyond

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins

(2017) René M. Arvola et al.   RNA Biology

Snapin mediates insulin secretory granule docking, but not trans-SNARE complex formation

(2016) Sangeeta Somanath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation

(2016) Wayne O. Miles et al.   CANCER RESEARCH

Distinct modes of recruitment of the CCR4–NOT complex byDrosophilaand vertebrate Nanos

(2016) Tobias Raisch et al.   EMBO JOURNAL

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

(2016) Chase A Weidmann et al.   eLife

RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells

(2015) Zhi Zhou et al.   DEVELOPMENTAL CELL

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

The humanNANOS3gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition

(2015) Simon Grelet et al.   JOURNAL OF PATHOLOGY

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

(2015) Inga Loedige et al.   Cell Reports

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

(2015) John D Laver et al.   GENOME BIOLOGY

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

(2014) W. O. Miles et al.   EMBO JOURNAL

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation

(2014) I. Loedige et al.   GENES & DEVELOPMENT

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

(2014) D. Bhandari et al.   GENES & DEVELOPMENT

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer

(2014) S Fernandez et al.   ONCOGENE

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation

(2014) Chase A. Weidmann et al.   RNA

Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans

(2014) Sven Leininger et al.   Nature Communications

Homozygous Inactivating Mutation inNANOS3in Two Sisters with Primary Ovarian Insufficiency

(2014) Mariza G. Santos et al.   Biomed Research International

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells

(2014) A. Suzuki et al.   Biology Open

Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena

(2014) Yo-Taro Shirai et al.   Frontiers in Genetics

Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line

(2013) Anthony D. Krentz et al.   DEVELOPMENTAL BIOLOGY

RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis

(2013) Riccardo Di Fiore et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations ofNANOS1, a human homologue of theDrosophilamorphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia

(2013) Kamila Kusz-Zamelczyk et al.   JOURNAL OF MEDICAL GENETICS

Repressive translational control in germ cells

(2013) Fangfang Lai et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Structure and assembly of the NOT module of the human CCR4–NOT complex

(2013) Andreas Boland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex

(2013) Varun Bhaskar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

(2013) Praveen Bawankar et al.   RNA Biology

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency

(2013) X Wu et al.   Cell Death & Disease

The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

(2013) Willy Joly et al.   Stem Cell Reports

Pumilio facilitates miRNA regulation of the E2F3 oncogene

(2012) W. O. Miles et al.   GENES & DEVELOPMENT

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells

(2011) Barbara Ginter-Matuszewska et al.   HISTOCHEMISTRY AND CELL BIOLOGY

NANOS3 function in human germ cell development

(2011) Vanessa T. Angeles Julaton et al.   HUMAN MOLECULAR GENETICS

Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor

(2011) C. A. Weidmann et al.   MOLECULAR AND CELLULAR BIOLOGY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Aubergine is a component of a nanos mRNA localization complex

(2010) Agata N. Becalska et al.   DEVELOPMENTAL BIOLOGY

Nanos1 functions as a translational repressor in the Xenopus germline

(2010) Fangfang Lai et al.   MECHANISMS OF DEVELOPMENT

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs

(2010) Atsushi Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

PUF proteins: repression, activation and mRNA localization

(2010) Tara Quenault et al.   TRENDS IN CELL BIOLOGY

The Translational Repressors Nanos and Pumilio Have Divergent Effects on Presynaptic Terminal Growth and Postsynaptic Glutamate Receptor Subunit Composition

(2009) K. P. Menon et al.   JOURNAL OF NEUROSCIENCE

The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells

(2009) B. Ginter-Matuszewska et al.   MOLECULAR HUMAN REPRODUCTION

The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction

(2009) K.M. Kusz et al.   MOLECULAR HUMAN REPRODUCTION

NANOS3gene mutations in men with isolated sterility phenotype

(2009) Kamila Kusz et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Snapin Facilitates the Synchronization of Synaptic Vesicle Fusion

(2009) Ping-Yue Pan et al.   NEURON

A 3′UTR Pumilio-Binding Element Directs Translational Activation in Olfactory Sensory Neurons

(2009) Julia A. Kaye et al.   NEURON

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency

(2009) Anthony D. Krentz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Combinatorial Code for CPE-Mediated Translational Control

(2008) Maria Piqué et al.   CELL

Germ cell specification and early embryonic patterning inBombyx morias revealed bynanosorthologues

(2008) Hajime Nakao et al.   EVOLUTION & DEVELOPMENT

Pumilio Binds para mRNA and Requires Nanos and Brat to Regulate Sodium Current in Drosophila Motoneurons

(2008) N. I. Muraro et al.   JOURNAL OF NEUROSCIENCE

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

(2008) Ralph A. Neumüller et al.   NATURE

The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression

(2008) A Bonnomet et al.   ONCOGENE

Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System

(2008) Alessia Galgano et al.   PLoS One

Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population

(2007) Francesca Lolicato et al.   DEVELOPMENTAL BIOLOGY