Article
Urology & Nephrology
Gang Xu, Shouhua Pan, Zhirong Zhu, Junlong Li
Summary: miR-340 functions as a tumor suppressor in bladder cancer by targeting Glut-1, leading to inhibition of proliferation and induction of apoptosis in bladder cancer cells. Additionally, miR-340 exerts its tumor suppressive role by regulating the expression of PCNA, Bax, and the PI3K/AKT pathway.
Article
Biotechnology & Applied Microbiology
Kun Li, Fengmei Han, Yanping Wu, Xue Wang
Summary: The study identified that miR-340 is highly expressed in retinoblastoma, enhancing cell proliferation, migration, and invasion by regulating WIF1. Moreover, multiple miRNAs and genes were identified that may contribute to a better understanding of the pathogenesis of the disease.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Qingan Jia, Xia Liao, Binghui Xu, Yufang Li, Lei Liang
Summary: This study aimed to investigate the level and function of miR-128-1-5p in colorectal cancer (CRC). The results showed that miR-128-1-5p was downregulated in CRC tissues and cell lines, and it inhibited cell proliferation and induced cell apoptosis by targeting PRKCQ.
CANCER BIOLOGY & THERAPY
(2023)
Article
Clinical Neurology
Li Liu, Li Jia, Jun Shao, Hanhua Liu, Qinke Wu, Xudong Wu
Summary: The study revealed that circNF1 is upregulated in glioblastoma and inhibits cell proliferation by promoting the maturation of miR-340, providing further insights into its potential role in tumors.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiaolong Qiao, Yinan Chen, Zixuan Wang, Nan Peng, Wanxiang Niu, Shiqiang Hou, Jiaying Wu, Ying Ji, Chaoshi Niu, Chuandong Cheng
Summary: The study shows that GTF2E2 is overexpressed in glioma and is associated with poor prognosis. The biological functions of GTF2E2 were investigated in vitro and in vivo, and it was found to be regulated by miR-340-5p, affecting downstream gene expressions and glioma progression.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Yazhen Xu, Bingyu Guo, Xiaoyan Liu, Kai Tao
Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The present study demonstrated that miR-1297 inhibited proliferation and tumor growth in osteosarcoma by directly targeting CCND2.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Gehao Liang, Yun Ling, Qun Lin, Yu Shi, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Jun Li, Chang Gong
Summary: In this study, the high expression of circCDYL in HER2(+) breast cancer tissue was found to promote cell proliferation independent of the miR-1275-ULK1/ATG7 autophagic axis. MiR-92b-3p was shown to cleave circCDYL in a silencing-dependent manner, and both circCDYL and miR-92b-3p were identified as potential biomarkers for predicting clinical outcomes in HER2(+) breast cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ge Yang, Mei Li, Qiwen Yang, Xiangqin Zhai, Jafari Halima, Qiaoyan Hu, Chuzhao Lei, Ruihua Dang
Summary: This study reveals that bta-miR-127 inhibits proliferation and promotes apoptosis of bovine Sertoli cells (SC) by downregulating ITGA6, which has implications for male fecundity and reproductive potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Min Gao, Tianyi Yu, Dan Liu, Yan Shi, Peilang Yang, Jie Zhang, Jizhuang Wang, Yan Liu, Xiong Zhang
Summary: The study investigated the effect of miR-1-3p on endothelial cells during sepsis, finding that miR-1-3p inhibits cell proliferation, promotes apoptosis and cytoskeleton contraction by targeting SERP1, leading to dysfunction of endothelial cells and weakening vascular barrier function. MiR-1-3p and SERP1 may be promising therapeutic candidates for sepsis-induced lung injury.
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Reproductive Biology
Haixia Wu, Youliang Yan, Jialin Yuan, Mengze Luo, Yingjian Wang
Summary: Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells. Therefore, we identified miR-4324 and FEN1 as potential therapeutic targets for ovarian cancer treatment.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Rong Cai, Yan-Ping Zhou, Yun-Hai Li, Jin-Jin Zhang, Zuo-Wei Hu
Summary: This study found that baicalin can promote apoptosis of colon cells and inhibit tumor growth. It was discovered that baicalin regulates the miR-139-3p/CDK16 pathway to inhibit proliferation and growth of colon cancer cells.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Oncology
Francesca Maria Orlandella, Raffaela Mariarosaria Mariniello, Peppino Mirabelli, Anna Elisa De Stefano, Paola Lucia Chiara Iervolino, Vito Alessandro Lasorsa, Mario Capasso, Rosa Giannatiempo, Maria Rongo, Mariarosaria Incoronato, Francesco Messina, Marco Salvatore, Andrea Soricelli, Giuliana Salvatore
BRITISH JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Immunology
Ioana Iurca, Alexandru Tirpe, Alina-Andreea Zimta, Cristian Moldovan, Diana Gulei, Ondrej Slaby, Gerolama Condorelli, Ioana Berindan-Neagoe
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Carla Lucia Esposito, Silvia Nuzzo, Maria Luigia Ibba, Lucia Ricci-Vitiani, Roberto Pallini, Gerolama Condorelli, Silvia Catuogno, Vittorio de Franciscis
Review
Oncology
Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli
Article
Medicine, General & Internal
Giovanni Smaldone, Luigi Coppola, Mariarosaria Incoronato, Rosanna Parasole, Mimmo Ripaldi, Luigi Vitagliano, Peppino Mirabelli, Marco Salvatore
Article
Biotechnology & Applied Microbiology
Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Summary: miR-34c-3p is a potential novel biomarker for positive prognosis in KRAS-mutated NSCLC patients, showing increased apoptosis and decreased proliferation in cells, and potentially targeting CDK1 for therapeutic purposes.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Summary: Exosomes are considered to have potential as early diagnostic biomarkers and regulators of cancer, including breast cancer. Through the Exo-SELEX strategy, a high-affinity aptamer was isolated that can specifically recognize exosomes from breast cancer cells. This molecule not only inhibits exosome cellular uptake, but also antagonizes cancer exosome-induced cell migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Chemistry, Multidisciplinary
Paolo Bevilacqua, Silvia Nuzzo, Enza Torino, Gerolama Condorelli, Marco Salvatore, Anna Maria Grimaldi
Summary: Nanoparticles are promising platforms for diagnostic and therapeutic tools, but accumulation in the spleen and liver poses challenges for their clinical application. Surface properties play a crucial role in fouling and antifouling behavior, making surface engineering of nanocarriers extremely important.
Article
Cardiac & Cardiovascular Systems
Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori
Summary: The study suggests that baseline uDKK3/uCr is a reliable marker for identifying patients with chronic kidney disease undergoing invasive coronary and peripheral procedures at risk for CA-AKI and persistent kidney dysfunction. Adding uDKK3/uCr to existing scoring systems can significantly improve predictions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Chemistry, Medicinal
Pasquale Russomanno, Giulia Assoni, Jussara Amato, Vincenzo Maria D'Amore, Riccardo Scaglia, Diego Brancaccio, Martina Pedrini, Giovanna Polcaro, Valeria La Pietra, Paolo Orlando, Marianna Falzoni, Linda Cerofolini, Stefano Giuntini, Marco Fragai, Bruno Pagano, Greta Donati, Ettore Novellino, Cristina Quintavalle, Gerolama Condorelli, Francesco Sabbatino, Pierfausto Seneci, Daniela Arosio, Stefano Pepe, Luciana Marinelli
Summary: A series of novel small organic molecules have been identified for their strong binding affinity with the PD-L1 protein, demonstrating the potential to challenge tumor cells in co-culture experiments without significant harm to healthy cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Genetics & Heredity
Francesco Musacchia, Marianthi Karali, Annalaura Torella, Steve Laurie, Valeria Policastro, Mariateresa Pizzo, Sergi Beltran, Giorgio Casari, Vincenzo Nigro, Sandro Banfi
Summary: VarGenius-HZD is a sensitive and scalable algorithm for the detection of rare homozygous and hemizygous single-exon deletions. It showed higher sensitivity compared to state-of-the-art algorithms in detecting rare HDs and successfully solved genetic diagnosis cases in patients with Inherited Retinal Dystrophies.
Article
Medicine, General & Internal
Rossana Castaldo, Nunzia Garbino, Carlo Cavaliere, Mariarosaria Incoronato, Luca Basso, Renato Cuocolo, Leonardo Pace, Marco Salvatore, Monica Franzese, Emanuele Nicolai
Summary: Radiomics plays an important role in cancer diagnosis and treatment. This study presents a weighted statistical framework to explore radiomic biomarkers for breast cancer and achieve more precise prognosis. The results show that normalizing radiomic features using the quantile method can lead to accurate classification and prediction of breast cancer outcomes.
Article
Biochemistry & Molecular Biology
Katia Pane, Mario Zanfardino, Anna Maria Grimaldi, Gustavo Baldassarre, Marco Salvatore, Mariarosaria Incoronato, Monica Franzese
Summary: By using integrated TCGA database and machine learning methods, we identified diagnostic miRNA expression signatures targeting the ERBB family in breast, ovarian, and endometrial cancers.
Review
Biochemistry & Molecular Biology
Anna Maria Grimaldi, Cristina Lapucci, Marco Salvatore, Mariarosaria Incoronato, Maurizio Ferrari
Summary: This systematic review analyzes the effectiveness of urine miRNAs as diagnostic markers for bladder cancer. Although there were high-quality studies, the results were quite heterogeneous and no consistent miRNA signature was found.