New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism
出版年份 2018 全文链接
标题
New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism
作者
关键词
-
出版物
BRITISH JOURNAL OF PHARMACOLOGY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-04-21
DOI
10.1111/bph.14337
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A kinetic view of GPCR allostery and biased agonism
- (2017) J Robert Lane et al. Nature Chemical Biology
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
- (2017) Simon D Harding et al. NUCLEIC ACIDS RESEARCH
- Crystal structure of the adenosine A2Areceptor bound to an antagonist reveals a potential allosteric pocket
- (2017) Bingfa Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity
- (2017) Robert K.Y. Cheng et al. STRUCTURE
- Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure
- (2017) James H. Felce et al. Cell Reports
- Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis
- (2017) Elizabeth A. Vecchio et al. Frontiers in Pharmacology
- Quantification of adenosine A 1 receptor biased agonism: Implications for drug discovery
- (2016) Jo-Anne Baltos et al. BIOCHEMICAL PHARMACOLOGY
- The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling
- (2016) Elizabeth A. Vecchio et al. BIOCHEMICAL PHARMACOLOGY
- Evidence for the heterotetrameric structure of the adenosine A 2A –dopamine D 2 receptor complex
- (2016) Verònica Casadó-Anguera et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
- (2016) Yi Zheng et al. NATURE
- Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor
- (2014) Zhan-Guo Gao et al. BIOCHEMICAL PHARMACOLOGY
- Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators
- (2014) Maria Letizia Trincavelli et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease
- (2014) Kjell Fuxe et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Synthesis and Pharmacological Evaluation of Dual Acting Ligands Targeting the Adenosine A2A and Dopamine D2 Receptors for the Potential Treatment of Parkinson’s Disease
- (2014) Manuela Jörg et al. JOURNAL OF MEDICINAL CHEMISTRY
- A3Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect:In VivoStudies and Molecular Mechanism of Action
- (2014) Shira Cohen et al. MEDIATORS OF INFLAMMATION
- Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist
- (2014) C. Valant et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biased ligands at G-protein-coupled receptors: promise and progress
- (2014) Jonathan D. Violin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Design, synthesis and biological evaluation of bivalent ligands against A1–D1 receptor heteromers
- (2013) Jian Shen et al. ACTA PHARMACOLOGICA SINICA
- Allosteric modulators of human A2B adenosine receptor
- (2013) Maria Letizia Trincavelli et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling
- (2013) P. Charukeshi Chandrasekera et al. CELLULAR SIGNALLING
- Interaction of δ and κ opioid receptors with adenosine A1 receptors mediates cardioprotection by remote ischemic preconditioning
- (2013) Harinee Surendra et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Fragment Screening of GPCRs Using Biophysical Methods: Identification of Ligands of the Adenosine A2A Receptor with Novel Biological Activity
- (2012) Dan Chen et al. ACS Chemical Biology
- The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation
- (2012) M.C. Peeters et al. BIOCHEMICAL PHARMACOLOGY
- The new oral adenosine A1 receptor agonist capadenoson in male patients with stable angina
- (2012) Michal Tendera et al. Clinical Research in Cardiology
- Synthesis and Characterization of Novel 2-Amino-3-benzoylthiophene Derivatives as Biased Allosteric Agonists and Modulators of the Adenosine A1 Receptor
- (2012) Celine Valant et al. JOURNAL OF MEDICINAL CHEMISTRY
- Functional selectivity of adenosine A1 receptor ligands?
- (2012) Ellen V. Langemeijer et al. Purinergic Signalling
- Bridging the gap: bitopic ligands of G-protein-coupled receptors
- (2012) J. Robert Lane et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein–Coupled Receptors
- (2011) Celine Valant et al. Annual Review of Pharmacology and Toxicology
- A2Aadenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase
- (2011) Eduard Gracia et al. BIOCHEMICAL JOURNAL
- Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers
- (2011) Zhan-Guo Gao et al. BIOCHEMICAL PHARMACOLOGY
- Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics
- (2011) Lauren T. May et al. FASEB JOURNAL
- International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update
- (2011) B. B. Fredholm et al. PHARMACOLOGICAL REVIEWS
- Adenosine receptor desensitization and trafficking
- (2010) Stuart Mundell et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Allosteric modulation of adenosine receptors
- (2010) Anikó Göblyös et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Adenosine A2A Receptor Is Involved in Cell Surface Expression of A2B Receptor
- (2010) Kengo Moriyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hybrid Ortho/Allosteric Ligands for the Adenosine A1Receptor
- (2010) Rajeshwar Narlawar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antagonist Selective Modulation of Adenosine A1 and A3 Receptor Pharmacology by the Food Dye Brilliant Black BN: Evidence for Allosteric Interactions
- (2010) L. T. May et al. MOLECULAR PHARMACOLOGY
- The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells
- (2010) L. T. May et al. MOLECULAR PHARMACOLOGY
- Design, synthesis and biological evaluation of a bivalent μ opiate and adenosine A1 receptor antagonist
- (2009) Smitha C. Mathew et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Plasma membrane diffusion of g protein-coupled receptor oligomers
- (2008) Stephen J. Briddon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Novel pharmacological targets based on receptor heteromers
- (2008) Rafael Franco et al. BRAIN RESEARCH REVIEWS
- Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique
- (2008) Jorge Gandia et al. FEBS LETTERS
- Synthesis of Bivalent β2-Adrenergic and Adenosine A1Receptor Ligands
- (2008) Peter Karellas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Translocation of arrestin induced by human A3 adenosine receptor ligands in an engineered cell line: Comparison with G protein-dependent pathways
- (2008) Z GAO et al. PHARMACOLOGICAL RESEARCH
- N6-1,3-Diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors
- (2007) Irene Giorgi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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