Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Large-scale interaction effects reveal missing heritability in schizophrenia, bipolar disorder and posttraumatic stress disorder

(2017) H J Woo et al.   Translational Psychiatry

A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population

(2017) Feng Wang et al.   Cell Discovery

Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases

(2017) Hyung Jun Woo et al.   PLoS One

Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism

(2016) Hyung Jun Woo et al.   BMC GENOMICS

The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway

(2016) Shuhei Ishikura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

(2016) Jérôme Nicod et al.   NATURE GENETICS

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

(2015) Norihiro Kato et al.   NATURE GENETICS

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

(2015) Yong Zhang et al.   NATURE IMMUNOLOGY

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension

(2014) Xiangfeng Lu et al.   HUMAN MOLECULAR GENETICS

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4

(2014) Justine Holleman et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

The pathophysiology of hypertension in patients with obesity

(2014) Vincent G. DeMarco et al.   Nature Reviews Endocrinology

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

(2013) Ting Ni et al.   BMC GENOMICS

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response

(2012) Keiko Doi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Genetics of Human Cardiovascular Disease

(2012) Sekar Kathiresan et al.   CELL

A Genome-Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex

(2012) Robert W. Davies et al.   Circulation-Cardiovascular Genetics

Cardiovascular Biology of the Incretin System

(2012) John R. Ussher et al.   ENDOCRINE REVIEWS

BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8

(2012) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits

(2012) Youling Guo et al.   PLoS One

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes

(2011) J. M. Locke et al.   DIABETOLOGIA

Role of Substance P in the Regulation of Glucose Metabolism via Insulin Signaling-Associated Pathways

(2011) Iordanes Karagiannides et al.   ENDOCRINOLOGY

Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour

(2011) J. F. Peden et al.   HUMAN MOLECULAR GENETICS

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

(2011) Fan Wang et al.   NATURE GENETICS

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

Under pressure: the search for the essential mechanisms of hypertension

(2011) Thomas M Coffman   NATURE MEDICINE

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

(2011) Guillaume Lettre et al.   PLoS Genetics

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Structure of Human Stabilin-1 Interacting Chitinase-like Protein (SI-CLP) Reveals a Saccharide-binding Cleft with Lower Sugar-binding Selectivity

(2010) Geng Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selected SALM (Synaptic Adhesion-Like Molecule) Family Proteins Regulate Synapse Formation

(2010) W. Mah et al.   JOURNAL OF NEUROSCIENCE

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Analysing biological pathways in genome-wide association studies

(2010) Kai Wang et al.   NATURE REVIEWS GENETICS

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

(2010) Ayellet V. Segrè et al.   PLoS Genetics

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

(2010) Sandosh Padmanabhan et al.   PLoS Genetics

Cross-talk between endocytic clearance and secretion in macrophages

(2009) Julia Kzhyshkowska et al.   IMMUNOBIOLOGY

Human genetics illuminates the paths to metabolic disease

(2009) Stephen O’Rahilly   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

Bicarbonate transport in cell physiology and disease

(2008) Emmanuelle Cordat et al.   BIOCHEMICAL JOURNAL

Translating molecular discoveries into new therapies for atherosclerosis

(2008) Daniel J. Rader et al.   NATURE

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS