标题
Antibody glycoengineering strategies in mammalian cells
作者
关键词
-
出版物
BIOTECHNOLOGY AND BIOENGINEERING
Volume 115, Issue 6, Pages 1378-1393
出版商
Wiley
发表日期
2018-02-22
DOI
10.1002/bit.26567
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Arabinosylation of recombinant human immunoglobulin-based protein therapeutics
- (2017) Patrick Hossler et al. mAbs
- Modulating IgG effector function by Fc glycan engineering
- (2017) Tiezheng Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Immunoregulatory Roles of Antibody Glycosylation
- (2017) Madeleine F. Jennewein et al. TRENDS IN IMMUNOLOGY
- Integrated Genome and Protein Editing Swaps α -2,6 Sialylation for α -2,3 Sialic Acid on Recombinant Antibodies from CHO
- (2017) Cheng-yu Chung et al. Biotechnology Journal
- Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity
- (2017) Benjamin Peschke et al. Frontiers in Immunology
- Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties
- (2017) Cheng Luo et al. Scientific Reports
- Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines
- (2016) Yusuke Mimura et al. JOURNAL OF IMMUNOLOGICAL METHODS
- The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor
- (2016) Ganesh P. Subedi et al. mAbs
- Fc-galactosylation modulates antibody-dependent cellular cytotoxicity of therapeutic antibodies
- (2016) Marco Thomann et al. MOLECULAR IMMUNOLOGY
- Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture
- (2015) Carina Villacrés et al. Biotechnology Journal
- One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment
- (2015) Lise Marie Grav et al. Biotechnology Journal
- Chinese hamster ovary (CHO) host cell engineering to increase sialylation of recombinant therapeutic proteins by modulating sialyltransferase expression
- (2015) Nan Lin et al. BIOTECHNOLOGY PROGRESS
- Functional knockout of FUT8 in Chinese hamster ovary cells using CRISPR/Cas9 to produce a defucosylated antibody
- (2015) Tao Sun et al. ENGINEERING IN LIFE SCIENCES
- Fc glycans of therapeutic antibodies as critical quality attributes
- (2015) Dietmar Reusch et al. GLYCOBIOLOGY
- Metabolic markers associated with high mannose glycan levels of therapeutic recombinant monoclonal antibodies
- (2015) Sohye Kang et al. JOURNAL OF BIOTECHNOLOGY
- Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity
- (2015) Isaak Quast et al. JOURNAL OF CLINICAL INVESTIGATION
- The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology
- (2015) Rinpei Niwa et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins
- (2015) Liming Liu JOURNAL OF PHARMACEUTICAL SCIENCES
- Production of α2,6-sialylated IgG1 in CHO cells
- (2015) Céline Raymond et al. mAbs
- Engineered CHO cells for production of diverse, homogeneous glycoproteins
- (2015) Zhang Yang et al. NATURE BIOTECHNOLOGY
- Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity
- (2015) Nathaniel Washburn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A common glycan structure on immunoglobulin G for enhancement of effector functions
- (2015) Chin-Wei Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Structural Role of Antibody N-Glycosylation in Receptor Interactions
- (2015) Ganesh P. Subedi et al. STRUCTURE
- Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
- (2015) Jae Seong Lee et al. Scientific Reports
- Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture
- (2015) Carina Villacrés et al. Biotechnology Journal
- One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment
- (2015) Lise Marie Grav et al. Biotechnology Journal
- In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity
- (2015) Marco Thomann et al. PLoS One
- Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool
- (2014) Carlotta Ronda et al. BIOTECHNOLOGY AND BIOENGINEERING
- Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans
- (2014) Helen H. Shi et al. BIOTECHNOLOGY AND BIOENGINEERING
- Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo
- (2014) Inessa Schwab et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes
- (2014) Albert Bondt et al. MOLECULAR & CELLULAR PROTEOMICS
- GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins
- (2014) Leander Meuris et al. NATURE BIOTECHNOLOGY
- Simply better glycoproteins
- (2014) Bernd Lepenies et al. NATURE BIOTECHNOLOGY
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Engineering Chinese Hamster Ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)—mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1)
- (2013) Natalie R. Sealover et al. JOURNAL OF BIOTECHNOLOGY
- The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody
- (2013) Bo Liu et al. JOURNAL OF BIOTECHNOLOGY
- Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies
- (2013) Xiaojie Yu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Glycoproteomic Analysis of Antibodies
- (2013) Gerhild Zauner et al. MOLECULAR & CELLULAR PROTEOMICS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
- (2013) James E. DiCarlo et al. NUCLEIC ACIDS RESEARCH
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
- (2013) Thomas Gaj et al. TRENDS IN BIOTECHNOLOGY
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I
- (2012) Xiaotian Zhong et al. BIOTECHNOLOGY AND BIOENGINEERING
- In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration
- (2012) Sandra Cristea et al. BIOTECHNOLOGY AND BIOENGINEERING
- Monoclonal antibody therapeutics: history and future
- (2012) Nicholas APS Buss et al. CURRENT OPINION IN PHARMACOLOGY
- IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1
- (2012) Inessa Schwab et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Galactosylation variations in marketed therapeutic antibodies
- (2012) T. Shantha Raju et al. mAbs
- Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
- (2012) Marcella Yu et al. mAbs
- Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation
- (2012) Fabian Käsermann et al. PLoS One
- The role of sialic acid as a modulator of the anti-inflammatory activity of IgG
- (2012) Sybille Böhm et al. Seminars in Immunopathology
- Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of α2,6-sialyltransferase derived from Chinese hamster ovary cells
- (2011) Masayoshi Onitsuka et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
- (2011) Michael J. Gramer et al. BIOTECHNOLOGY AND BIOENGINEERING
- The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
- (2011) Xun Xu et al. NATURE BIOTECHNOLOGY
- Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies
- (2010) Laetitia Malphettes et al. BIOTECHNOLOGY AND BIOENGINEERING
- Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase
- (2010) H. H. von Horsten et al. GLYCOBIOLOGY
- Analytical and Functional Aspects of Antibody Sialylation
- (2010) Johannes Stadlmann et al. JOURNAL OF CLINICAL IMMUNOLOGY
- A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs
- (2010) Robert M. Anthony et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Production of therapeutic antibodies with controlled fucosylation
- (2010) Naoko Yamane-Ohnuki et al. mAbs
- Engineering host cell lines to reduce terminal sialylation of secreted antibodies
- (2010) Michael F. Naso et al. mAbs
- Genome editing with engineered zinc finger nucleases
- (2010) Fyodor D. Urnov et al. NATURE REVIEWS GENETICS
- Glycosylation as a strategy to improve antibody-based therapeutics
- (2009) Roy Jefferis NATURE REVIEWS DRUG DISCOVERY
- A close look at human IgG sialylation and subclass distribution after lectin fractionation
- (2009) Johannes Stadlmann et al. PROTEOMICS
- Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells
- (2008) M. Peipp et al. BLOOD
- Terminal sugars of Fc glycans influence antibody effector functions of IgGs
- (2008) T Shantha Raju CURRENT OPINION IN IMMUNOLOGY
- Decrease in antithrombin III fucosylation by expressing GDP-fucose transporter siRNA in Chinese hamster ovary cells
- (2008) Takeshi Omasa et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
- (2008) Elena E Perez et al. NATURE BIOTECHNOLOGY
- Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc
- (2008) R. M. Anthony et al. SCIENCE
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