Review
Hematology
Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A. Fisher
Summary: Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Genetics & Heredity
Meichun Wu, Min Xun, Yuping Chen
Summary: Circular RNAs control the phenotypic adaptation, proliferation, migration, apoptosis, and senescence of vascular smooth muscle cells under multiple stimuli, affecting the progression of cardiovascular diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Cardiac & Cardiovascular Systems
Myungsuk Kim, Md Nazmul Huda, Brian J. Bennett
Summary: The role of gut microbiota in human health, particularly in cardiovascular diseases, has been recognized. Several potential mechanisms, including gut permeability and endotoxemia, increased immune system activation, and microbial derived metabolites, have been proposed to explain the associations between gut microbiota and cardiovascular diseases. Understanding the mode of action of the gut microbiota in disease susceptibility and severity is crucial. Additionally, the intersection of metabolomics and microbiota research may provide novel targets to reduce disease susceptibility.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Xiaopei Cui, Guopin Pan, Ye Chen, Xiaosun Guo, Tengfei Liu, Jing Zhang, Xiaofan Yang, Mei Cheng, Haiqing Gao, Fan Jiang
Summary: Pathological vascular remodeling plays a critical role in various vascular diseases, and activation of p53 may help counteract vascular remodeling and reduce inflammation. Currently, targeting the p53 pathway through pharmacological interventions could be a novel strategy to prevent the development of vascular remodeling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Mascha Koenen, Michael A. Hill, Paul Cohen, James R. Sowers
Summary: Cardiovascular diseases, as the leading cause of death worldwide, are strongly associated with overweight and obesity, which contribute to vascular dysfunction and cardiovascular diseases. The abnormal remodeling of specific adipose tissue depots during obesity plays a critical role in the development of hypertension, endothelial dysfunction, and vascular stiffness, with fat distribution being a key determinant of the risk for cardiovascular diseases.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hui-Hsuan Lin, Ming-Chang Hsieh, Chi-Ping Wang, Pei-Rong Yu, Ming-Shih Lee, Jing-Hsien Chen
Summary: In this study, GTIN was found to inhibit VSMCs proliferation and migration, reduce ROS generation, and potentially play a role in controlling atherosclerosis and other cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Tanyaporn Pattarabanjird, Melissa Marshall, Aditi Upadhye, Prasad Srikakulapu, James C. Garmey, Antony Haider, Angela M. Taylor, Esther Lutgens, Coleen A. McNamara
Summary: This study reveals a novel role for P62 in driving BAFF-induced B1b cell proliferation and IgM(OSE) production to attenuate diet-induced atherosclerosis. Results also identify a direct role for Id3 in antagonizing E2A from activating the p62 promoter. Moreover, analysis of putative human B1 cells also implicates these pathways in coronary artery disease subjects, suggesting P62 as a new immunomodulatory target for treating atherosclerosis.
CIRCULATION RESEARCH
(2022)
Review
Hematology
Carmen Yap, Arnout Mieremet, Carlie J. M. de Vries, Dimitra Micha, Vivian de Waard
Summary: Multiple layers of vascular smooth muscle cells (vSMCs) form the media of blood vessels, providing structure and regulating blood flow. vSMCs exhibit high plasticity and can switch between different phenotypes, with a total of 6 phenotypes identified. The central dedifferentiated vSMC type is the mesenchymal-like phenotype, which can differentiate into various other cell types contributing to vascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Plant Sciences
Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng
Summary: This study investigated the therapeutic efficiency of gastrodin as an antihypertensive and determined the mechanisms underlying its effects. The results showed that gastrodin lowered blood pressure, suppressed vascular contraction, and inhibited activation of the MLCK/p-MLC2 pathway, demonstrating its therapeutic efficacy as an antihypertensive.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Health Care Sciences & Services
Chenkai Wu, Kehan Zhang, Michelle C. Odden, Anna M. Kucharska-Newton, Priya Palta, Kunihiro Matsushita, Rebecca F. Gottesman, B. Gwen Windham
Summary: The study found that a high burden of subclinical vascular disease in middle-aged adults is associated with an increased risk of premature mortality, providing better predictive ability for premature death. When designing interventions to reduce premature mortality, the importance of considering subclinical vascular disease factors should be taken into account.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sheila Gonzalez-Salvatierra, Cristina Garcia-Fontana, Jesus Lacal, Francisco Andujar-Vera, Luis Martinez-Heredia, Raquel Sanabria de la Torre, Maria Ferrer-Millan, Enrique Moratalla-Aranda, Manuel Munoz-Torres, Beatriz Garcia-Fontana
Summary: The study aimed to determine the levels of Sclerostin in patients with type 2 diabetes (T2D) and vascular smooth muscle cells (VSMCs), and to investigate its role under calcified conditions. The results showed higher levels of Sclerostin in T2D patients, which were associated with cardiovascular disease (CVD). In vitro experiments demonstrated that overexpression of Sclerostin reduced calcium deposits, decreased cell proliferation and inflammation, and promoted cell survival.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Changpo Lin, Lirong Xu, Xiao Tang, Xiaobo Li, Chao Lu, Qianyun Cheng, Junhao Jiang, Yang Shen, Dong Yan, Ruizhe Qian, Weiguo Fu, Daqiao Guo
Summary: Disruption of Bmal1 in VSMCs worsens atherosclerosis by promoting VSMC migration and monocyte transmigration and impairing antioxidant function. Therefore, Bmal1 may be a potential therapeutic target and biomarker of atherosclerosis in the future.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Peripheral Vascular Disease
William B. Earle, Jordan K. Kondo, Karla N. Kendrick, Ruth-Alma Turkson-Ocran, Long Ngo, Jennifer L. Cluett, Kenneth J. Mukamal, Natalie Daya Malek, Elizabeth Selvin, Pamela L. Lutsey, Josef Coresh, Stephen P. Juraschek
Summary: This study compares the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults.
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Bhupinder Kapoor, Monica Gulati, Pooja Rani, Rajpal Singh Kochhar, Atanas G. Atanasov, Reena Gupta, Deepika Sharma, Deepak Kapoor
Summary: This article reviews the neuroprotective effects of lycopene in the treatment of Alzheimer's disease (AD) and discusses the evidence from various studies and investigations on its protective effects. The mechanisms through which lycopene exerts its remissive effects in AD and the development of novel delivery systems for lycopene are also discussed briefly.
Article
Pharmacology & Pharmacy
Harish Vancha, Devesh Tewari, Rajesh Kumar, Pilli Govindaiah, Sharfuddin Mohd, Sachin Kumar Singh, Monica Gulati
Summary: This study aimed to develop an analytical method for the estimation of xanthohumol (XH) in nanoformulations. A quality by design (QbD)-based UV-visible spectrophotometric method was developed and validated, which showed good linearity, accuracy, and precision. The developed method can be used for the estimation of XH in nanoformulations.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Public, Environmental & Occupational Health
Mojca Hribersek, Fabian Eibensteiner, Lorenz Kapral, Anna Teufel, Faisal A. Nawaz, Merisa Cenanovic, Chandragiri Siva Sai, Hari Prasad Devkota, Ronita De, Rajeev K. Singla, Emil D. Parvanov, Christos Tsagkaris, Atanas G. Atanasov, Eva Schaden
Summary: This study explores the communication between hospital-based healthcare providers and patients' loved ones, focusing on the rigorous mitigation measures implemented during the COVID-19 pandemic. The findings highlight the importance of communication between patients, their loved ones, and hospitals, and the barriers to communication beyond visitation restrictions. The study emphasizes the implementation of family-centered care in adult nursing clinical practice.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Analytical
Xiaomu Zhu, Ting Zhou, Shu Wang, Bengui Ye, Rajeev K. Singla, Devesh Tewari, Atanas G. Atanasov, Dongdong Wang, Simei Liu
Summary: In this study, an UPLC-ESI-MS/MS method was developed for the simultaneous quantification of nine steroidal alkaloids in Fritillariae cirrhosae bulbus (FCB) and its substitutes. Multivariate chemometric analyses were applied to distinguish FCB from its substitutes, and four compounds were discovered as potential markers for identification.
Review
Medicine, Legal
Sweta Kumari, Biplab Pal, Sanjeev Kumar Sahu, Pranav Kumar Prabhakar, Devesh Tewari
Summary: Clenbuterol, a potent beta-2 agonist, is widely misused by athletes, despite the lack of evidence for its performance-enhancing effects. This systematic review evaluated the adverse events associated with clenbuterol among athletes. 23 studies were included, and the most commonly occurring adverse events were cardiac-related complications.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Plant Sciences
Sweta Bawari, Archana N. Sah, Pawan Gupta, Gokhan Zengin, Devesh Tewari
Summary: This study aimed to establish the antiurolithiatic potential of Citrus jambhiri fruit juice and elucidate its mechanism of action. The results showed that the juice reduced nucleation, growth, and aggregation of calcium oxalate crystals, as well as improved various urinary parameters associated with urolithiasis in experimental rats. Docking studies revealed the binding potential of phytoconstituents in C. jambhiri with glycolate oxidase and matrix metalloproteinase-9. In conclusion, C. jambhiri fruit juice possesses excellent antiurolithiatic activity by restoring the equilibrium between stone formation promoters and inhibitors and inhibiting matrix metalloproteinases and glycolate oxidase.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iga Bartel, Magdalena Koszarska, Nina Strzalkowska, Nikolay T. T. Tzvetkov, Dongdong Wang, Jaroslaw O. Horbanczuk, Agnieszka Wierzbicka, Atanas G. G. Atanasov, Artur Jozwik
Summary: Type 2 diabetes is a global health problem caused by a combination of environmental and genetic factors. In order to prevent and mitigate the negative consequences of type 2 diabetes, a nutritional diet rich in bioactive compounds such as polyphenols, including cyanidin-3-O-glucosidase (C3G), can be beneficial. C3G has been shown to have positive effects on diabetic parameters, including reducing inflammation, blood glucose levels, and postprandial hyperglycemia, as well as regulating gene expression related to the development of type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Vancha Harish, Sharfuddin Mohd, Devesh Tewari, Narendra Kumar Pandey, Sukriti Vishwas, Malakapogu Ravindra Babu, Mohamad Ayman Salkini, Zia Ur Rehman, Jehan Talaq Alotaibi, Renad Fahad Alotaibi, Fahad Abdulaziz Alrashed, Parteek Prasher, Nitin Sharma, Gaurav Gupta, Vikash Jakhmola, Yogendra Singh, Terezinha de Jesus Andreoli Pinto, Keshav Raj Paudel, Neeraj Mittal, Thakur Gurjeet Singh, Poonam Arora, Kamal Dua, Sachin Kumar Singh
Summary: In recent years, solid lipid nanoparticles (SLNs) have attracted significant research interest due to their ability to encapsulate drugs in their core, deliver drugs to specific targets, and protect drugs from the gastrointestinal environment. This review discusses the historical background and development of SLNs in nanotechnology. It also focuses on the composition, fabrication techniques, mechanism, and advantages of SLNs. The review highlights the biopharmaceutical aspects and challenges associated with the clinical translation of SLNs for improving the bioavailability, stability, and solubility of lipophilic and gastrointestinal labile drugs used in treating chronic diseases.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Dongdong Wang, Logan K. Townsend, Genevieve J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A. Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A. Pileggi, Sonia Rehal, Eric M. Desjardins, Evangelia E. Tsakiridis, James S. V. Lally, Emma Sara Juracic, A. Russell Tupling, Hertzel C. Gerstein, Guillaume Pare, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J. Hawke, John R. Speakman, Denis P. Blondin, Graham P. Holloway, Sebastian Beck Jorgensen, Gregory R. Steinberg
Summary: Caloric restriction is effective in treating non-alcoholic fatty liver disease and improving insulin sensitivity, but weight loss is usually not maintained due to physiological adaptations that suppress energy expenditure. Treatment with recombinant GDF15 can reduce obesity and improve glycaemic control by suppressing food intake. Additionally, GDF15 counteracts compensatory reductions in energy expenditure, leading to greater weight loss and improvements in non-alcoholic fatty liver disease compared to caloric restriction alone. This effect of GDF15 on maintaining energy expenditure during calorie restriction requires a GFRAL-beta-adrenergic-dependent signaling axis.
Editorial Material
Endocrinology & Metabolism
Logan K. Townsend, Dongdong Wang, David C. Wright, Denis P. Blondin
Article
Health Care Sciences & Services
Olena Litvinova, Fabian Peter Hammerle, Jivko Stoyanov, Natalia Ksepka, Maima Matin, Michal Lawinski, Atanas G. Atanasov, Harald Willschke
Summary: This study conducted a comprehensive patent and bibliometric analysis to explore the development and application of pulse oximeters in the field of digital medicine. The findings highlight the increasing importance of pulse oximeters in digitally-enabled medical practice and identify six primary research clusters related to these devices. The study suggests the potential of leveraging digital technologies in pulse oximetry for advancing the understanding, diagnosis, prevention, and treatment of cardio-respiratory pathologies.
Article
Plant Sciences
Donghan Cui, Yajuan Chen, Bengui Ye, Wenhao Guo, Dongdong Wang, Jun He
Summary: Neurodegenerative diseases are common in older adults, and natural products have shown promising results in improving these diseases. Recent studies have identified neuroinflammatory mechanisms and signaling pathways associated with the occurrence and development of these diseases. This study aims to review the mechanism of action of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease, providing a theoretical basis for clinical practice.
Review
Biotechnology & Applied Microbiology
Zhi-Min Zhao, Zhi-Hua Liu, Tongtong Zhang, Rongqian Meng, Zhiqun Gong, Yibing Li, Jing Hu, Arthur J. Ragauskas, Bing-Zhi Li, Ying-Jin Yuan
Summary: Bioconversion of bioresources/wastes using Rhodococcus is a promising approach for producing lipid-derived bioproducts. However, bioconversion involves living cells and is a complex system that requires further understanding. This review highlights the potential of Rhodococcus for producing lipids from various wastes and presents genetic modifications using emerging tools for promoting bioconversion. Additionally, strategies for enhancing the bioaccessibility of lignin and its derived aromatics and synthesizing biodiesel and aviation fuels from lignin and lipids are discussed. The synergistic modification of microbial strains, substrates, and fermentation processes is proposed for sustainable biological lignin valorization.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Maddy L. Newby, Joel D. Allen, Max Crispin
Summary: A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins. Glycosylation can influence the antigenicity and immunogenicity of vaccines, with native-like glycosylation potentially enhancing immunogenicity. Understanding viral glycosylation can guide the development of future vaccines in various enveloped viruses.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Uganeeswary Suparmaniam, Man Kee Lam, Jun Wei Lim, Inn Shi Tan, Bridgid Lai Fui Chin, Siew Hoong Shuit, Steven Lim, Yean Ling Pang, Peck Loo Kiew
Summary: Microalgae have the ability to synthesize high-value phytochemicals, and subjecting them to abiotic stress can enhance the accumulation of valuable metabolites within their cells. This study explores the effects of manipulating abiotic stress on microalgae yields and discusses approaches to increase HVPCs production using abiotic stress.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Pei Zhou, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu, Xiulai Chen
Summary: The engineering status of protein is crucial for the efficient bioproduction in microbial cell factories. Strategies such as protein engineering, protein modification, and protein assembly can effectively modify the protein status and enhance production efficiency.
BIOTECHNOLOGY ADVANCES
(2024)