GDF15 promotes weight loss by enhancing energy expenditure in muscle

Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study

(2022) Susan Martin et al.   DIABETES CARE

Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells

(2022) Jaroslawna Meister et al.   Nature Communications

Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity

(2022) Brittany Galuppo et al.   Nutrition & Diabetes

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

(2022) Berit Østergaard Christoffersen et al.   Obesity

Dietary nitrate increases submaximal SERCA activity and ADP transfer to mitochondria in slow-twitch muscle of female mice

(2022) Heather L. Petrick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

(2022) Marisa R. Morrow et al.   Cell Metabolism

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults

(2022) Sumei Hu et al.   Cell Metabolism

Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

(2022) Satish Patel et al.   Molecular Metabolism

GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease

(2021) Dongdong Wang et al.   Nature Reviews Endocrinology

Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15

(2021) Irene Cimino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Daily energy expenditure through the human life course

(2021) Herman Pontzer et al.   SCIENCE

Stress-induced FGF21 and GDF15 in obesity and obesity resistance

(2021) Susanne Keipert et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ten simple rules for conducting a mendelian randomization study

(2021) Sarah A. Gagliano Taliun et al.   PLoS Computational Biology

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

(2021) Yi Liu et al.   eLife

Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals

(2021) Christoffer Martinussen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of GDF15 as a Myomitokine

(2021) Kornelia Johann et al.   Cells

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

(2020) Julian M. Yabut et al.   Nature Communications

GDF15: A hormone conveying somatic distress to the brain

(2020) Samuel M Lockhart et al.   ENDOCRINE REVIEWS

Impact of calorie restriction on energy metabolism in humans

(2020) Jasper Most et al.   EXPERIMENTAL GERONTOLOGY

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

(2020) Rowena Suriben et al.   NATURE MEDICINE

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

Contribution of perfusion to the 11 C‐acetate signal in brown adipose tissue assessed by DCE‐MRI and 68 Ga‐DOTA PET in a rat model

(2020) Gabriel Richard et al.   MAGNETIC RESONANCE IN MEDICINE

The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?

(2020) Samuel N. Breit et al.   Annual Review of Physiology

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

(2020) Olivier Govaere et al.   Science Translational Medicine

Insights Into Mechanisms of GDF15 and Receptor GFRAL: Therapeutic Targets

(2020) Luc Rochette et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

(2019) Henriette Frikke-Schmidt et al.   Molecular Metabolism

Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue

(2019) Marie Anne Richard et al.   EJNMMI Research

Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)

(2019) Huaiyu Mi et al.   Nature Protocols

Life-long reduction in myomiR expression does not adversely affect skeletal muscle morphology

(2019) Ivan J. Vechetti et al.   Scientific Reports

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

GDF15 deficiency promotes high fat diet-induced obesity in mice

(2018) Thanhvien Tran et al.   PLoS One

The Role of Sarcolipin in Muscle Non-shivering Thermogenesis

(2018) Naresh C. Bal et al.   Frontiers in Physiology

Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition

(2017) Kevin D. Hall et al.   GASTROENTEROLOGY

Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease

(2017) Bo Kyung Koo et al.   LIVER INTERNATIONAL

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

The Role of the Autonomic Nervous System in the Pathophysiology of Obesity

(2017) Daniela Guarino et al.   Frontiers in Physiology

In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport

(2016) P. M. Miotto et al.   BIOCHEMICAL JOURNAL

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity

(2015) Santosh K. Maurya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C

(2015) Cuiying Xiao et al.   Obesity

Design of Diverging Stacked Bar Charts for Likert Scales and Other Applications

(2015) Richard M. Heiberger et al.   Journal of Statistical Software

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

(2014) Vicky Wang-Wei Tsai et al.   PLoS One

A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo

(2014) Justin D. Crane et al.   Molecular Metabolism

Sarcolipin Protein Interaction with Sarco(endo)plasmic Reticulum Ca2+ATPase (SERCA) Is Distinct from Phospholamban Protein, and Only Sarcolipin Can Promote Uncoupling of the SERCA Pump

(2013) Sanjaya K. Sahoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model

(2013) S. L. Thorn et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

(2013) Chady H. Hakim et al.   Jove-Journal of Visualized Experiments

Caffeine-stimulated fatty acid oxidation is blunted in CD36 null mice

(2012) J. S. V. Lally et al.   Acta Physiologica

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice

(2012) Yann Ravussin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Adaptive thermogenesis can make a difference in the ability of obese individuals to lose body weight

(2012) A Tremblay et al.   INTERNATIONAL JOURNAL OF OBESITY

Metabolic Slowing with Massive Weight Loss despite Preservation of Fat-Free Mass

(2012) Darcy L. Johannsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis

(2012) Darin Bloemberg et al.   PLoS One

Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals

(2010) Patricia Iozzo et al.   GASTROENTEROLOGY

Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity

(2010) Martin F. Gerrits et al.   JOURNAL OF LIPID RESEARCH

FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle

(2009) Graham P. Holloway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Kinetic models for analysing myocardial [11C]palmitate data

(2009) Hugo W. A. M. de Jong et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

(2008) Nicolas Dzamko et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

(2008) Andrey V Kuznetsov et al.   Nature Protocols

Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

(2008) Gordon S. Lynch et al.   PHYSIOLOGICAL REVIEWS