An enhanced genome-scale metabolic reconstruction of Streptomyces clavuligerus identifies novel strain improvement strategies

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Flux balance analysis in the production of clavulanic acid byStreptomyces clavuligerus

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Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production inStreptomyces coelicolorA3(2)

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Comparison and analysis of objective functions in flux balance analysis

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Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0

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Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement

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Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation

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Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium

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Biosynthesis of clavam metabolites

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Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes

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SurreyFBA: a command line tool and graphics user interface for constraint-based modeling of genome-scale metabolic reaction networks

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Systems metabolic engineering: Genome-scale models and beyond

(2010) John Blazeck et al.   Biotechnology Journal

The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

(2010) Marnix H. Medema et al.   Genome Biology and Evolution

The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene

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What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

(2010) Marnix H. Medema et al.   Microbial Biotechnology

Alanylclavam Biosynthetic Genes Are Clustered Together with One Group of Clavulanic Acid Biosynthetic Genes in Streptomyces clavuligerus

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Selection of objective function in genome scale flux balance analysis for process feed development in antibiotic production

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