Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement

Biosynthesis of clavam metabolites

(2012) Susan E. Jensen   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes

(2011) Hum Nath Jnawali et al.   BIOTECHNOLOGY LETTERS

Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus

(2011) I. Santamarta et al.   MOLECULAR MICROBIOLOGY

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

(2010) Ju Yeon Song et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Draft Genome Sequence of Streptomyces clavuligerus NRRL 3585, a Producer of Diverse Secondary Metabolites

(2010) J. Y. Song et al.   JOURNAL OF BACTERIOLOGY

Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585

(2010) Hum Nath Jnawali et al.   MICROBIOLOGICAL RESEARCH

Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant

(2010) M. T. Lopez-Garcia et al.   MICROBIOLOGY-SGM

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

(2010) Marnix H. Medema et al.   Microbial Biotechnology

Glycerol Utilization Gene Cluster in Streptomyces clavuligerus

(2009) S. Banos et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome shuffling: Progress and applications for phenotype improvement

(2009) Jixian Gong et al.   BIOTECHNOLOGY ADVANCES

A Two-component Regulatory System Involved in Clavulanic Acid Production

(2009) Hum Nath Jnawali et al.   JOURNAL OF ANTIBIOTICS

Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus

(2009) Si-Hai Xiang et al.   METABOLIC ENGINEERING

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus

(2008) Paloma Liras et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production

(2008) Ju Yeon Song et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp

(2008) J. P. Gomez-Escribano et al.   MICROBIOLOGY-SGM