Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse

iRhoms; Its Functions and Essential Roles

(2016) Min-Young Lee et al.   Biomolecules & Therapeutics

DW2007 Ameliorates Colitis and Rheumatoid Arthritis in Mice by Correcting Th17/Treg Imbalance and Inhibiting NF-κB Activation

(2016) Su-Min Lim et al.   Biomolecules & Therapeutics

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9

(2015) Satoshi Hara et al.   Scientific Reports

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Structure and Mechanism of Rhomboid Protease

(2013) Ya Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

(2013) Priya Darshinee A. Issuree et al.   JOURNAL OF CLINICAL INVESTIGATION

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Regulated Intramembrane Cleavage of the EGF Receptor

(2012) Hong-Jun Liao et al.   TRAFFIC

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH