Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

Sampling the membrane: function of rhomboid-family proteins

(2013) Marius K. Lemberg   TRENDS IN CELL BIOLOGY

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

(2012) Silva Saarinen et al.   Familial Cancer

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Multiple Loci Modulate Opioid Therapy Response for Cancer Pain

(2011) A. Galvan et al.   CLINICAL CANCER RESEARCH

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

(2010) Matthias Canault et al.   PLoS One

Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice

(2008) Richard W. Gelling et al.   ENDOCRINOLOGY

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

(2008) Huafei Zou et al.   FASEB JOURNAL

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS

Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts

(2008) Prashant Mali et al.   STEM CELLS