iRhoms; Its Functions and Essential Roles

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

With blood in the joint - what happens next? Could activation of a pro-inflammatory signalling axis leading to iRhom2/TNFα-convertase-dependent release of TNFα contribute to haemophilic arthropathy?

(2014) C. Haxaire et al.   HAEMOPHILIA

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

(2014) Matthew A. Brooke et al.   HUMAN MOLECULAR GENETICS

ADAM17 at the interface between inflammation and autoimmunity

(2014) Sabrina Lisi et al.   IMMUNOLOGY LETTERS

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

(2014) O. M. Siggs et al.   Biology Open

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Structure and Mechanism of Rhomboid Protease

(2013) Ya Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sampling the membrane: function of rhomboid-family proteins

(2013) Marius K. Lemberg   TRENDS IN CELL BIOLOGY

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

Rhomboid proteins: a role in keratinocyte proliferation and cancer

(2012) Sarah L. Etheridge et al.   CELL AND TISSUE RESEARCH

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

(2012) Silva Saarinen et al.   Familial Cancer

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas

(2012) Claudia Abbruzzese et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Regulated Intramembrane Cleavage of the EGF Receptor

(2012) Hong-Jun Liao et al.   TRAFFIC

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

The rhomboid protease family: a decade of progress on function and mechanism

(2011) Sinisa Urban et al.   GENOME BIOLOGY

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS