Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts

Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts

(2017) Seul-Ki Park et al.   EXPERIMENTAL DERMATOLOGY

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

Hutchinson–Gilford Progeria Syndrome: A Premature Aging Disease

(2017) Muhammad Saad Ahmed et al.   MOLECULAR NEUROBIOLOGY

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

(2017) Diana Gabriel et al.   Oncotarget

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype

(2017) Diana Gabriel et al.   PLoS One

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

(2017) Zheng-Mei Xiong et al.   Scientific Reports

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

(2016) Camilla Evangelisti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

(2016) Michael I. Robson et al.   MOLECULAR CELL

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

(2016) S Blondel et al.   Cell Death & Disease

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

(2016) Ray Kreienkamp et al.   Oncotarget

Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome

(2016) Rafal Czapiewski et al.   Frontiers in Genetics

Chromatin at the nuclear periphery and the regulation of genome functions

(2015) Charlene Lemaître et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function

(2015) Juhi Misra et al.   STEM CELLS

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

(2015) Camilla Pellegrini et al.   Oncotarget

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

(2015) Zoe E Gillespie et al.   Nucleus

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells

(2015) Katrin Bercht Pfleghaar et al.   Nucleus

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

(2015) Zoe E Gillespie et al.   Nucleus

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells

(2015) Katrin Bercht Pfleghaar et al.   Nucleus

Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome

(2014) Leslie B. Gordon et al.   CIRCULATION

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

(2014) C. A. Bannister et al.   DIABETES OBESITY & METABOLISM

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson-Gilford Progeria Syndrome

(2014) Sophie Blondel et al.   Stem Cells Translational Medicine

Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting

(2014) Di Wu et al.   Nucleus

Stochastic genome-nuclear lamina interactions

(2014) Jop Kind et al.   Nucleus

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts

(2013) Bidisha Saha et al.   AGING CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

IMACULAT — An Open Access Package for the Quantitative Analysis of Chromosome Localization in the Nucleus

(2013) Ishita Mehta et al.   PLoS One

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability

(2013) Arindam Das et al.   Nucleus

DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations

(2013) Bidisha Saha et al.   Frontiers in Genetics

Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome

(2012) John J. Graziotto et al.   Autophagy

Mapping of lamin A- and progerin-interacting genome regions

(2012) Nard Kubben et al.   CHROMOSOMA

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

(2012) L. B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes

(2011) Hisashi Ohnuki et al.   ARCHIVES OF ORAL BIOLOGY

Loss of A-type lamins and genomic instability

(2011) Ignacio Gonzalez-Suarez et al.   CELL CYCLE

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

(2011) Shane A. Richards et al.   HUMAN MOLECULAR GENETICS

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

(2011) Ishita S Mehta et al.   GENOME BIOLOGY

Gene expression, chromosome position and lamin A/C mutations

(2011) Megan J. Puckelwartz et al.   Nucleus

Progeria, the nucleolus and farnesyltransferase inhibitors

(2010) Ishita S. Mehta et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exploring the relationship between interphase gene positioning, transcriptional regulation and the nuclear matrix

(2010) Lauren S. Elcock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A–type lamins

(2010) Winnok H. De Vos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts

(2010) Dan Constantinescu et al.   EXPERIMENTAL CELL RESEARCH

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

(2010) Stephanie K. Mewborn et al.   PLoS One

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

(2010) G. Marino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts

(2010) Ishita S Mehta et al.   GENOME BIOLOGY

Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF

(2009) Alexandre Ottaviani et al.   EMBO JOURNAL

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Organization of the lamin scaffold in the internal nuclear matrix of normal and transformed hepatocytes

(2009) Paola Barboro et al.   EXPERIMENTAL CELL RESEARCH

Premature aging in vitamin D receptor mutant mice

(2009) Tiina Keisala et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dynamics of Telomeres and Promyelocytic Leukemia Nuclear Bodies in a Telomerase-negative Human Cell Line

(2009) Thibaud Jegou et al.   MOLECULAR BIOLOGY OF THE CELL

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the effects of a dysfunctional nuclear matrix

(2008) Lauren S. Elcock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?

(2008) Ishita S. Mehta et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

FISH glossary: an overview of the fluorescence in situ hybridization technique

(2008) Emanuela V. Volpi et al.   BIOTECHNIQUES

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells

(2008) V. Raz et al.   JOURNAL OF CELL SCIENCE

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE