Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies

(2017) Ricardo J. Ferreira et al.   Scientific Reports

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

The multidrug transporter ABCG2: still more questions than answers

(2016) A. J. Horsey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques

(2016) Kelvin Wong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter

(2016) Laura László et al.   PLoS One

Allocrite Sensing and Binding by the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1)

(2015) Yanyan Xu et al.   BIOCHEMISTRY

Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter

(2015) Zita Gál et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

(2015) A. J. Haider et al.   BIOSCIENCE REPORTS

Do Drugs Have Access to the P-Glycoprotein Drug-Binding Pocket through Gates?

(2015) Ricardo J. Ferreira et al.   Journal of Chemical Theory and Computation

Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation

(2015) Mark F. Rosenberg et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Target for an Old Drug: Identifying Mitoxantrone as a Nanomolar Inhibitor of PIM1 Kinase via Kinome-Wide Selectivity Modeling

(2013) Xiaobo Wan et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

(2013) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Towards understanding promiscuity in multidrug efflux pumps

(2013) Kelvin Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity

(2011) Zhanglin Ni et al.   BIOCHEMISTRY

The controversial role of ABC transporters in clinical oncology

(2011) Akina Tamaki et al.   Essays in Biochemistry

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport

(2010) Zhanglin Ni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty

(2010) Ian D Kerr et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone

(2010) Mark F. Rosenberg et al.   STRUCTURE

Multidrug Resistance in Bacteria

(2009) Hiroshi Nikaido   Annual Review of Biochemistry

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

(2008) Christopher A. McDevitt et al.   FEBS Journal

Effect of Cysteine Mutagenesis on the Function and Disulfide Bond Formation of Human ABCG2

(2008) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein

(2007) J. Lawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES