Article
Cell Biology
Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang
Summary: The gene RNF186 has been identified in genome-wide association studies as a susceptibility gene for ulcerative colitis, and it plays a crucial role in autophagy activation in colonic epithelial cells and intestinal homeostasis by regulating the ubiquitination of EPHB2. The absence of RNF186 and EPHB2 leads to a more severe phenotype in a colitis model, while treatment with ephrin-B1-Fc recombinant protein shows promise as a potential therapy for inflammatory bowel diseases.
Article
Pharmacology & Pharmacy
Lin Zhang, Jian Cheng, Jie Shen, Sheng Wang, Chuanyong Guo, Xiaoming Fan
Summary: Ulcerative colitis (UC) is an inflammatory bowel disease that affects the lining of the rectum and colon. Ghrelin plays a protective role in UC progression by regulating the unfolded protein response pathway and inhibiting apoptosis of intestinal epithelial cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Imteyaz Ahmad Khan, Baibaswata Nayak, Manasvini Markandey, Aditya Bajaj, Mahak Verma, Sambudhha Kumar, Mukesh Kumar Singh, Saurabh Kedia, Vineet Ahuja
Summary: Crohn's disease and Intestinal tuberculosis are chronic intestinal diseases with similar phenotype but diverse etiologies. This study found a higher prevalence of host gene polymorphisms and pathobionts in colonic mucosa of patients with CD compared to ITB.
Article
Pharmacology & Pharmacy
Bingyu Wang, Zhiqiang Gong, Jingyu Zhan, Lei Yang, Quanyu Zhou, Xingxing Yuan
Summary: Xianglian pill (XLP) has been found to alleviate DSS-induced acute colitis in mice by inhibiting pro-inflammatory cytokines secretion, repairing intestinal epithelial barrier dysfunction, enhancing autophagy, and blocking the activation of the PI3K/Akt/mTOR pathway. Blocking autophagy attenuated the protective effects of XLP on colitis, suggesting that the underlying mechanism may involve Xianglian pill promoting autophagy by blocking the activation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nai-Yun Hsu, Shikha Nayar, Kyle Gettler, Sayali Talware, Mamta Giri, Isaac Alter, Carmen Argmann, Ksenija Sabic, Tin Htwe Thin, Huai-Bin Mabel Ko, Robert Werner, Christopher Tastad, Thaddeus Stappenbeck, Aline Azabdaftari, Holm H. Uhlig, Ling-Shiang Chuang, Judy H. Cho
Summary: This study reveals the association between NOX1 deficiency, TNF alpha stimulation, and colitis. ROS production is reduced in NOX1-deficient colonoids, affecting the stem cell niche and cell differentiation. The findings suggest that modulation of ROS could be a potential therapeutic approach for IBD in the future.
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Pharmacology & Pharmacy
Yaying You, Yongtao Xiao, Ying Lu, Jun Du, Hui Cai, Wei Cai, Weihui Yan
Summary: The pathogenesis of IBD is complicated and still unclear. This study found that through the activation of NOD2 and MDP, gut inflammation can be alleviated and intestinal barrier repair can be promoted by regulating autophagy in intestinal epithelial cells, reducing intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Cell Biology
Wenxu Pan, Li Xiang, Xinhua Liang, Wenjun Du, Junhong Zhao, Song Zhang, Xuan Zhou, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: In this study, it was found that highly expressed VTN disrupted the differentiation of IECs in IBD patients through PDE4-mediated ferroptosis, suggesting targeting PDE4 could be a promising therapeutic strategy for patients with IBD.
MEDIATORS OF INFLAMMATION
(2023)
Article
Cell Biology
Danhua Yao, Zhiyuan Zhou, Pengfei Wang, Lei Zheng, Yuhua Huang, Yantao Duan, Bin Liu, Yousheng Li
Summary: The study demonstrated that miR-125-5p plays a crucial role in ulcerative colitis by targeting IL-6 R, with its up-regulation reducing inflammatory factor expression, cell apoptosis, and inhibiting the activation of JAK1/STAT3 and NF-kappa B pathways. This research suggests that miR-125-5p could serve as a potential therapeutic target for ulcerative colitis.
Article
Medicine, Research & Experimental
Hao Liu, Jun Lou, Yunlong Liu, Zhen Liu, Jiansheng Xie, Jiachun Sun, Hongming Pan, Weidong Han
Summary: This study reveals the essential role of autophagy in the development of colitis-associated cancer. Autophagy deficiency leads to the accumulation of T cells in the colon lamina propria and reduces the risk of tumor initiation and progression. Additionally, autophagy protects against intestinal injury by maintaining epithelial barrier function and promoting the survival and proliferation of epithelial cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Cell Biology
Artin Soroosh, Kai Fang, Jill M. Hoffman, Ivy K. M. Law, Elizabeth Videlock, Zulfiqar A. Lokhandwala, Jonathan J. Zhao, Sepehr Hamidi, David M. Padua, Mark R. Frey, Charalabos Pothoulakis, Carl R. Rankin
Summary: This study found that miR-24-3p restrains intestinal epithelial cell apoptosis by targeting BIM, and its loss of function is detrimental to epithelial restitution following intestinal inflammation.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Mikael E. Sellin, Kendle M. Maslowski, Kevin J. Maloy, Wolf-Dietrich Hardt
TRENDS IN IMMUNOLOGY
(2015)
Editorial Material
Immunology
Johanna Pott, Kevin J. Maloy, Ana Izcue
Editorial Material
Immunology
Andrea Lei, Kevin J. Maloy
TRENDS IN IMMUNOLOGY
(2016)
Article
Biology
Agnieszka M. Kabat, Oliver J. Harrison, Thomas Riffelmacher, Amin E. Moghaddam, Claire F. Pearson, Adam Laing, Lucie Abeler-Doerner, Simon P. Forman, Richard K. Grencis, Quentin Sattentau, Anna Katharina Simon, Johanna Pott, Kevin J. Maloy
Review
Immunology
Agnieszka M. Kabat, Johanna Pott, Kevin J. Maloy
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Nathaniel R. West, Ahmed N. Hegazy, Benjamin M. J. Owens, Samuel J. Bullers, Bryan Linggi, Sofia Buonocore, Margherita Coccia, Dieter Goertz, Sebastien This, Krista Stockenhuber, Johanna Pott, Matthias Friedrich, Grigory Ryzhakov, Frederic Baribaud, Carrie Brodmerkel, Constanze Cieluch, Nahid Rahman, Gerhard Mueller-Newen, Raymond J. Owens, Anja A. Kuehl, Kevin J. Maloy, Scott E. Plevy, Satish Keshav, Simon P. L. Travis, Fiona Powrie
Review
Immunology
Andrea C. Lei-Leston, Alison G. Murphy, Kevin J. Maloy
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Microbiology
Johanna Pott, Agnieszka Martyna Kabat, Kevin Joseph Maloy
CELL HOST & MICROBE
(2018)
Article
Immunology
Pedro A. C. Costa, Maria M. Figueiredo, Suelen Q. Diniz, Ana P. M. M. Peixoto, Kevin J. Maloy, Andrea Teixeira-Carvalho, Mauro S. Tada, Dhelio B. Pereira, Ricardo T. Gazzinelli, Lis R. V. Antonelli
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Paola De Cicco, Theodore Sanders, Giuseppe Cirino, Kevin J. Maloy, Angela Ianaro
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
Cristina Dumitru, Agnieszka M. Kabat, Kevin J. Maloy
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
Philip P. Ahern, Kevin J. Maloy
Review
Immunology
Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy
Summary: Intestinal epithelial cells play a dual role in antigen presentation, potentially activating effector T cells while also suppressing immune responses through regulatory T cell activation. The expression of MHC class II on IECs is tightly regulated and its impact on immune responses can vary depending on the specific conditions and cellular context.
Article
Cell Biology
Luara Isabela dos Santos, Thais Abdala Torres, Suelen Queiroz Diniz, Ricardo Goncalves, Gustavo Caballero-Flores, Gabriel Nunez, Ricardo Tostes Gazzinelli, Kevin Joseph Maloy, Lis Ribeiro do Antonelli
Summary: Co-infection with Plasmodium chabaudi and Citrobacter rodentium leads to prolonged systemic bacterial persistence and high mortality, potentially due to disrupted iron metabolism, elevated plasma heme levels, and increased mitochondrial reactive oxygen species production by phagocytes. Iron acquisition by the bacterium plays a critical role in pathogenesis and mortality during co-infection.
