Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Jin Yuan, Xiaoqian Xu, Zhongliang Wang, Ping Tong, Xuanyi Meng, Yong Wu, Xin Li, Jinyan Gao, Hongbing Chen
Summary: This study aimed to characterize the differentiations of naive Th cells stimulated with different doses of Staphylococcus aureus enterotoxin B (SEB). The results showed that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation, with a higher dose inducing more Th1 cells and a lower Th2/Th1 ratio. This finding complements the existing knowledge about SEB as a superantigen and has implications for managing S. aureus colonization and SEB contamination in food.
Article
Multidisciplinary Sciences
Gentaro Izumi, Hideki Nakano, Keiko Nakano, Gregory S. Whitehead, Sara A. Grimm, Michael B. Fessler, Peer W. Karmaus, Donald N. Cook
Summary: This study identified a subpopulation of cDCs in the lung of mice that can promote Th17 differentiation, showing a stepwise developmental progression from immature Ly-6C(+)Ly-6A/E+ cDC2 to mature cDC2. Through single cell RNA sequencing and adoptive transfer experiments, the researchers found that different stages of maturation and phenotype of mouse lung DC can promote Th17 or Th2 CD4(+) T cell differentiation.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Yan Qin, Chong Gao, Jing Luo
Summary: The abnormal number and function of immune cells are the basis for various diseases. Recent studies have shown that the altered metabolic state of immune cells exists in autoimmune diseases and affects the occurrence and development of inflammation. This review summarizes the biology and function of Th17 and Treg cells in autoimmune diseases, with emphasis on the regulatory role of energy metabolism in the activation, differentiation, and physiological function of these cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stefano Piazza, Marco Fumagalli, Giulia Martinelli, Carola Pozzoli, Nicole Maranta, Marco Angarano, Enrico Sangiovanni, Mario Dell'Agli
Summary: Plants rich in hydrolyzable tannins have traditionally been used for the treatment of chronic inflammatory disorders. However, limited knowledge of their immunological targets hinders their rational use in phytotherapy. Recent advances in understanding the pathogenesis of inflammatory-based diseases provide an opportunity to elucidate the pharmacological mechanisms of these plant-derived metabolites with immunomodulatory activity. This review summarizes recent articles on the role of hydrolyzable tannins and their gut metabolites in various inflammatory responses.
Review
Oncology
Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian, Eyad Elkord
Summary: Metabolic dysregulation in the hypoxic tumor microenvironment plays a crucial role in the development of solid tumors, particularly in the metabolic reprogramming of Tregs. This reprogramming can affect the biological properties of Tregs, increasing their presence and proliferation within the TME. Understanding and regulating the metabolism of Tregs may have important implications for the treatment of tumors.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Medicine, General & Internal
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Summary: This study introduces EDP1815, a non-colonizing pharmaceutical preparation derived from a single strain of Prevotella histicola. The research demonstrates that EDP1815 can regulate inflammatory responses throughout the body when taken orally and restricted to the gut.
FRONTIERS IN MEDICINE
(2023)
Review
Immunology
Jongdae Lee, Beatriz Lozano-Ruiz, Fengyuan Mandy Yang, Dengxia Denise Fan, Liya Shen, Jose M. Gonzalez-Navajas
Summary: Immune checkpoint inhibition has become a key aspect of cancer therapy, with CD4(+) T cells playing a crucial role in modulating immune responses against tumors. Different subsets of helper T cells have varying impacts on the clinical response to immune checkpoint therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Yu Wang, Juan Sun, Lamei Xue, Jinxin Liu, Chenzhipeng Nie, Mingcong Fan, Haifeng Qian, Duo Zhang, Hao Ying, Yan Li, Li Wang
Summary: L-arabinose demonstrates anti-allergic effects by reducing levels of IgE, histamine, and Th2-related cytokines, while increasing levels of Th1-related cytokines. It also improves intestinal barrier function by suppressing inflammation signaling pathways. Additionally, L-arabinose enhances Treg cell populations and related factors, suggesting it as a promising agent for alleviating gliadin allergy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Yanxia Zhou, Ke Yu
Summary: The study revealed that Th1 and Th17 cells are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients, indicating their potential role in the pathogenesis of these psychological and cognitive issues. Further validation is required for confirmation.
FRONTIERS IN SURGERY
(2022)
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Philip P. Ahern, Kevin J. Maloy
Review
Immunology
Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy
Summary: Intestinal epithelial cells play a dual role in antigen presentation, potentially activating effector T cells while also suppressing immune responses through regulatory T cell activation. The expression of MHC class II on IECs is tightly regulated and its impact on immune responses can vary depending on the specific conditions and cellular context.
Article
Microbiology
Marcela Montes de Oca, Fabian de Labastida Rivera, Clay Winterford, Teija C. M. Frame, Susanna S. Ng, Fiona H. Amante, Chelsea L. Edwards, Luzia Bukali, Yulin Wang, Jude E. Uzonna, Rachel D. Kuns, Ping Zhang, Agnieszka Kabat, Ramon I. Klein Geltink, Edward J. Pearce, Geoffrey R. Hill, Christian R. Engwerda
Article
Cell Biology
Mauro Corrado, Joy Edwards-Hicks, Matteo Villa, Lea J. Flachsmann, David E. Sanin, Maaike Jacobs, Francesc Baixauli, Michal Stanczak, Eve Anderson, Mai Azuma, Andrea Quintana, Jonathan D. Curtis, Thomas Clapes, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan Kyle, Annette E. Patterson, Ramon Klein Geltink, Borko Amulic, Colin G. Steward, Douglas Strathdee, Eirini Trompouki, David O'Sullivan, Edward J. Pearce, Erika L. Pearce
Article
Cell Biology
Luara Isabela dos Santos, Thais Abdala Torres, Suelen Queiroz Diniz, Ricardo Goncalves, Gustavo Caballero-Flores, Gabriel Nunez, Ricardo Tostes Gazzinelli, Kevin Joseph Maloy, Lis Ribeiro do Antonelli
Summary: Co-infection with Plasmodium chabaudi and Citrobacter rodentium leads to prolonged systemic bacterial persistence and high mortality, potentially due to disrupted iron metabolism, elevated plasma heme levels, and increased mitochondrial reactive oxygen species production by phagocytes. Iron acquisition by the bacterium plays a critical role in pathogenesis and mortality during co-infection.
Article
Multidisciplinary Sciences
Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hueser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Oellinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Mueller, Pierluigi Ramadori, Valentina Leone, Cristina Garcia-Caceres, Tim Gruber, Gabriel Seifert, Agnieszka M. Kabat, Jan-Philipp Malm, Simon Reider, Maria Effenberger, Susanne Roth, Adrian T. Billeter, Beat Mueller-Stich, Edward J. Pearce, Friedrich Koch-Nolte, Rafael Kaeser, Herbert Tilg, Robert Thimme, Tobias Boettler, Frank Tacke, Jean-Francois Dufour, Dirk Haller, Peter J. Murray, Ron Heeren, Dietmar Zehn, Jan P. Boettcher, Mathias Heikenwaelder, Percy A. Knolle
Summary: Liver resident CD8 T cells play an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis. These cells display specific phenotypic and metabolic characteristics in the liver, making them susceptible to metabolic stimuli and leading to auto-aggressive responses. This study sheds light on the mechanisms underlying liver damage in NASH and highlights the distinction between auto-aggressive and protective T cell immunity.
Article
Biochemistry & Molecular Biology
Daniel J. Puleston, Francesc Baixauli, David E. Sanin, Joy Edwards-Hicks, Matteo Villa, Agnieszka M. Kabat, Marcin M. Kaminski, Michal Stanckzak, Hauke J. Weiss, Katarzyna M. Grzes, Klara Piletic, Cameron S. Field, Mauro Corrado, Fabian Haessler, Chao Wang, Yaarub Musa, Lena Schimmelpfennig, Lea Flachsmann, Gerhard Mittler, Nir Yosef, Vijay K. Kuchroo, Joerg M. Buescher, Stefan Balabanov, Edward J. Pearce, Douglas R. Green, Erika L. Pearce
Summary: Polyamine synthesis plays a critical role in T cell activation and differentiation, regulating CD4(+) T cells' function and epigenetic remodeling. Studies have revealed the significance of polyamine metabolism in controlling the fate of T-H cell subsets, with deficiency leading to aberrant expression of cytokines and transcription factors.
Article
Immunology
Katarzyna M. Grzes, David E. Sanin, Agnieszka M. Kabat, Michal A. Stanczak, Joy Edwards-Hicks, Mai Matsushita, Alexandra Hackl, Fabian Haessler, Kristin Knoke, Sophie Zahalka, Matteo Villa, David M. Kofler, Reinhard E. Voll, Paola Zigrino, Mario Fabri, Erika L. Pearce, Edward J. Pearce
Summary: IL-3-induced expression of amino acid transporters in pDCs activates mTORC1 nutrient sensor, leading to cytokine production. Inhibition of amino acid transporters and ENPP2 can block cytokine production, providing additional therapeutic targets for autoimmune diseases involving pDCs.
Article
Allergy
Antonie Lechner, Fiona D. R. Henkel, Franziska Hartung, Sina Bohnacker, Francesca Alessandrini, Ekaterina O. Gubernatorova, Marina S. Drutskaya, Carlo Angioni, Yannick Schreiber, Pascal Haimerl, Yan Ge, Dominique Thomas, Agnieszka M. Kabat, Edward J. Pearce, Caspar Ohnmacht, Sergei A. Nedospasov, Peter J. Murray, Adam M. Chaker, Carsten B. Schmidt-Weber, Julia Esser-von Bieren
Summary: This study reveals the existence of macrophage-trained immunity in allergic asthma, characterized by inflammatory transcriptional reprogramming and excessive mediator responses. Allergen-triggered inflammation drives a TNF-dependent innate memory, which may perpetuate and exacerbate chronic type 2 airway inflammation and thus represents a target for asthma therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biology
Stefanie Dichtl, David E. Sanin, Carolin K. Koss, Sebastian Willenborg, Andreas Petzold, Maria C. Tanzer, Andreas Dahl, Agnieszka M. Kabat, Laura Lindenthal, Leonie Zeitler, Sabrina Satzinger, Alexander Strasser, Matthias Mann, Axel Roers, Sabine A. Eming, Karim C. El Kasmi, Edward J. Pearce, Peter J. Murray
Summary: Anti-TNF therapies can protect against chronic diseases by modulating the balance of macrophage activity, specifically regulating components of tissue and reparative M2 macrophages.
LIFE SCIENCE ALLIANCE
(2022)
Article
Cell Biology
George Caputa, Mai Matsushita, David E. Sanin, Agnieszka M. Kabat, Joy Edwards-Hicks, Katarzyna M. Grzes, Roland Pohlmeyer, Michal A. Stanczak, Angela Castoldi, Jovana Cupovic, Aaron J. Forde, Petya Apostolova, Maximilian Seidl, Nikki van Teijlingen Bakker, Matteo Villa, Francesc Baixauli, Andrea Quintana, Alexandra Hackl, Lea Flachsmann, Fabian Hassler, Jonathan D. Curtis, Annette E. Patterson, Philipp Henneke, Erika L. Pearce, Edward J. Pearce
Summary: This study reveals that adipose tissue can acquire anti-bacterial function during bacterial infection through the recognition and stimulation by innate lymphocytes. This process is mediated by the induction of iNOS expression in adipocytes, leading to the production of nitric oxide (NO) for bacterial clearance.
Article
Immunology
David E. Sanin, Yan Ge, Emilija Marinkovic, Agnieszka M. Kabat, Angela Castoldi, George Caputa, Katarzyna M. Grzes, Jonathan D. Curtis, Elizabeth A. Thompson, Sebastian Willenborg, Stefanie Dichtl, Susanne Reinhardt, Andreas Dahl, Erika L. Pearce, Sabine A. Eming, Alexander Gerbaulet, Axel Roers, Peter J. Murray, Edward J. Pearce
Summary: Macrophages display heterogeneity and different activation patterns in different organs and inflammatory conditions. By building a predictive model, we identified four conserved activation paths for macrophages. This integrative classification approach helps us understand and predict the activation patterns of macrophages in inflammation and homeostasis.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Francesc Baixauli, Klara Piletic, Daniel J. Puleston, Matteo Villa, Cameron S. Field, Lea J. Flachsmann, Andrea Quintana, Nisha Rana, Joy Edwards-Hicks, Mai Matsushita, Michal A. Stanczak, Katarzyna M. Grzes, Agnieszka M. Kabat, Mario Fabri, George Caputa, Beth Kelly, Mauro Corrado, Yaarub Musa, Katarzyna J. Duda, Gerhard Mittler, David O'Sullivan, Hiromi Sesaki, Thomas Jenuwein, Joerg M. Buescher, Edward J. Pearce, David E. Sanin, Erika L. Pearce
Summary: CD4(+) T cell differentiation requires metabolic reprogramming and mitochondrial membrane remodelling. OPA1 regulates mitochondrial fusion and cristae morphology, and affects TCA cycle metabolism in T(H)17 cells. Mitochondrial membrane disruption activates LKB1, restrains IL-17 expression, and deletion of LKB1 restores IL-17 expression in T(H)17 cells.
Article
Immunology
Agnieszka M. Kabat, Alexandra Hackl, David E. Sanin, Patrice Zeis, Katarzyna M. Grzes, Francesc Baixauli, Ryan Kyle, George Caputa, Joy Edwards-Hicks, Matteo Villa, Nisha Rana, Jonathan D. Curtis, Angela Castoldi, Jovana Cupovic, Leentje Dreesen, Maria Sibilia, J. Andrew Pospisilik, Joseph F. Urban, Dominic Gruen, Erika L. Pearce, Edward J. Pearce
Summary: Type 2 immunity is associated with adipose tissue homeostasis and infection with parasitic helminths. During infection, the fat content of mesenteric adipose tissue declines and is accompanied by the accumulation of metabolically activated stromal cells. Resident T helper 2 cells infiltrate the adipose tissue and produce cytokines in response to immune signaling molecules. These interactions within the interstitium are important for orchestrating adipose tissue remodeling and immunity to intestinal infection.
SCIENCE IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ramon I. Klein Geltink, Joy Edwards-Hicks, Petya Apostolova, David O'Sullivan, David E. Sanin, Annette E. Patterson, Daniel J. Puleston, Nina A. M. Ligthart, Joerg M. Buescher, Katarzyna M. Grzes, Agnieszka M. Kabat, Michal Stanczak, Jonathan D. Curtis, Fabian Hassler, Franziska M. Uhl, Mario Fabri, Robert Zeiser, Edward J. Pearce, Erika L. Pearce