Rigidity versus flexibility: the dilemma of understanding protein thermal stability

Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function

(2014) Stephen A. Wells et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Temperature and the catalytic activity of enzymes: A fresh understanding

(2013) Roy M. Daniel et al.   FEBS LETTERS

The universality of enzymatic rate–temperature dependency

(2013) Mikael Elias et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus

(2012) Ekaterina Y. Bezsudnova et al.   BIOCHIMIE

Application of principal component analysis to determine the key structural features contributing to iron superoxide dismutase thermostability

(2012) Yanrui Ding et al.   BIOPOLYMERS

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity

(2012) Yimingjiang Wuxiuer et al.   FEBS Journal

Thermostabilizing mutations preferentially occur at structural weak spots with a high mutation ratio

(2012) Prakash C. Rathi et al.   JOURNAL OF BIOTECHNOLOGY

Global and local indices for characterizing biomolecular flexibility and rigidity

(2012) Christopher Pfleger et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

(2012) Seema Mittal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of loop dynamics in thermal stability of mesophilic and thermophilic adenylosuccinate synthetase: A molecular dynamics and normal mode analysis study

(2011) Satyavani Vemparala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

How Do Thermophilic Proteins and Proteomes Withstand High Temperature?

(2011) Lucas Sawle et al.   BIOPHYSICAL JOURNAL

Physical limits of cells and proteomes

(2011) K. A. Dill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily Conserved Linkage between Enzyme Fold, Flexibility, and Catalysis

(2011) Arvind Ramanathan et al.   PLOS BIOLOGY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Enhanced Stability of a Protein with Increasing Temperature

(2010) Joachim M. Vinther et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigations of the thermostability of rubredoxin models using molecular dynamics simulations

(2010) Elizabeth A. Bradley et al.   PROTEIN SCIENCE

2D 1H and 3D 1H-15N NMR of zinc-rubredoxins: Contributions of the β-sheet to thermostability

(2010) Kimberly A. Richie et al.   PROTEIN SCIENCE

Do salt bridges stabilize proteins? A continuum electrostatic analysis

(2010) Zachary S. Hendsch et al.   PROTEIN SCIENCE

Protein rigidity and thermophilic adaptation

(2010) Sebastian Radestock et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A new understanding of how temperature affects the catalytic activity of enzymes

(2010) Roy M. Daniel et al.   TRENDS IN BIOCHEMICAL SCIENCES

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series

(2009) Olga Khersonsky et al.   JOURNAL OF MOLECULAR BIOLOGY

Analyzing the Flexibility of RNA Structures by Constraint Counting

(2008) Simone Fulle et al.   BIOPHYSICAL JOURNAL

Exploiting the Link between Protein Rigidity and Thermostability for Data-Driven Protein Engineering

(2008) S. Radestock et al.   ENGINEERING IN LIFE SCIENCES