STAT3 the oncogene - still eluding therapy?

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

(2015) Li Lin et al.   NEOPLASIA

A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

(2014) Wei Huang et al.   ACS Chemical Biology

Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC

(2014) Yuan Hu et al.   APOPTOSIS

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Low PIAS3 Expression in Malignant Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival

(2014) S. Dabir et al.   CLINICAL CANCER RESEARCH

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

(2014) Gautam Sethi et al.   Molecular Cancer

Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors

(2014) R. W. Tell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway

(2014) Hongyi Zhang et al.   STEM CELLS

The role of pacritinib in the management of myelofibrosis

(2014) Vu H Duong et al.   Expert Review of Hematology

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

(2013) Keunsoo Kang et al.   BMC GENOMICS

Is there a future for cell-penetrating peptides in oligonucleotide delivery?

(2013) Soo Hyeon Lee et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

(2013) Olga A. Timofeeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STA-21, a Promising STAT-3 Inhibitor That Reciprocally Regulates Th17 and Treg Cells, Inhibits Osteoclastogenesis in Mice and Humans and Alleviates Autoimmune Inflammation in an Experimental Model of Rheumatoid Arthritis

(2013) Jin-Sil Park et al.   Arthritis & Rheumatology

Peptides As Therapeutics with Enhanced Bioactivity

(2012) D. Goodwin et al.   CURRENT MEDICINAL CHEMISTRY

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements

(2012) A. Chase et al.   HAEMATOLOGICA

Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2012) Bikash Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binding Modes of Peptidomimetics Designed to Inhibit STAT3

(2012) Ankur Dhanik et al.   PLoS One

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand Simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)

(2011) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor

(2010) Ken Miyoshi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

(2010) Sunil Badve et al.   MODERN PATHOLOGY

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Palmitoylation of Interferon-α (IFN-α) Receptor Subunit IFNAR1 Is Required for the Activation of Stat1 and Stat2 by IFN-α

(2009) Julie Claudinon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of unphosphorylated STAT3 core fragment

(2008) Zhiyong Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

(2008) Wenshan Hao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck

(2008) A. L. Boehm et al.   MOLECULAR PHARMACOLOGY

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling

(2008) Gabriella Regis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY