Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Oncology
Antonia Piazzesi, Sumaiya Yasmeen Afsar, Gerhild Van Echten-Deckert
Summary: Cancer development is a complex process involving overcoming obstacles such as unrestricted proliferation, invasion, nutrient supply, and metastasis, while evading the immune system. Inflammation plays a role in cancer development, with sphingolipid metabolism impacting cells' progression from healthy to cancerous phenotypes.
MOLECULAR ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Yanfei Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, Pu Xia
Summary: Sphingolipids play a crucial role in cell membrane structure and intracellular signaling pathways. Sphingosine kinase (SphK) is an important enzyme in sphingolipid metabolism, with implications in both physiological and pathological processes, including type 2 diabetes mellitus (T2D). There is ongoing debate about the specific role of SphK in T2D, but it is believed to be a potential target for future anti-diabetes therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex, chronic, immunologically mediated disease that is associated with numerous other diseases. It can cause impairment of quality of life and may be associated with depressive disorders. The pathophysiology of psoriasis and its comorbidities is not fully understood yet, and disrupted metabolism of sphingolipids may be the link between them.
Article
Biochemistry & Molecular Biology
Albena Momchilova, Roumen Pankov, Galya Staneva, Stefan Pankov, Plamen Krastev, Evgenia Vassileva, Rusina Hazarosova, Nikolai Krastev, Bozhil Robev, Biliana Nikolova, Adriana Pinkas
Summary: Resveratrol regulates sphingolipid metabolism in lung cancer cells, leading to changes in CER and S1P levels, and showing anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Albena Momchilova, Georgi Nikolaev, Stefan Pankov, Evgenia Vassileva, Nikolai Krastev, Bozhil Robev, Dimo Krastev, Adriana Pinkas, Roumen Pankov
Summary: This study analyzed the effects of quercetin and fingolimod on sphingolipid metabolism in HepG2 cells. The results showed that quercetin and fingolimod, alone or in combination, can reduce sphingolipid levels and activate certain enzymes. The up-regulation and down-regulation of specific enzymes and proteins by quercetin have important implications for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jae-Hwi Song, Goon-Tae Kim, Kyung-Ho Park, Woo-Jae Park, Tae-Sik Park
Summary: Atherosclerosis is characterized by plaque deposition in major arteries and involves inflammation, macrophages, endothelial cells, and various sphingolipids such as ceramides, glycosphingolipids, and S1P. Inhibition of de novo ceramide biosynthesis and regulation by S1P receptor (S1PR) can impact the development of atherosclerosis. S1PR1 and S1PR3 have anti-atherosclerotic properties, with ceramide and S1P playing crucial roles in the atherogenic process.
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang
Summary: Many cardiovascular disorders are characterized by endothelial cell dysfunction, which is closely related to sphingolipid metabolism. Understanding the effects of sphingolipid metabolites and key enzymes on endothelial cells can provide insights into the pathogenesis of cardiovascular diseases and potential therapeutic targets.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Food Science & Technology
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collen, Philippe Guerre
Summary: The study analyzed the effects of FB on hepatic and plasma sphingolipidome in chickens, showing that alterations in sphingolipids can lead to toxic manifestations and can potentially serve as a biomarker of exposure to FB.
Article
Biochemistry & Molecular Biology
Lorena Perez-Carrillo, Isaac Gimenez-Escamilla, Luis Martinez-Dolz, Ignacio Jose Sanchez-Lazaro, Manuel Portoles, Esther Rosello-Lleti, Estefania Tarazon
Summary: Disturbances in sphingolipid metabolism contribute to the development of heart failure by causing an accumulation of ceramide and S1P in cardiac tissue, as well as an increase in the ceramide/S1P ratio. Therapeutic gene modulation aimed at restoring ceramide levels or reversing the ceramide/S1P ratio could be a potential treatment strategy for heart failure patients.
Article
Immunology
Samar M. M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates
Summary: SLE is a chronic autoimmune disease with African American SLE patients showing higher levels of certain sphingolipids, which are correlated with the severity of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang Li
Summary: This article reviews the role and mechanism of sphingolipids in brain insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Bartlomiej Lukaszuk, Marta Lewoc, Hend Malla, Piotr Mysliwiec, Jacek Dadan, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex chronic immunologically mediated disease that affects the skin, nails, and joints. Abnormal levels of sphingolipids significantly differ between psoriatic skin and healthy skin, suggesting their potential role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yasharah Raza, Jane Atallah, Chiara Luberto
Summary: Dysregulation of sphingolipid metabolism plays a complex role in hematological malignancies, contributing to the design of combinatorial therapeutic regimens and reducing resistance to standard therapies. Inhibitors targeting specific nodes of the sphingolipid pathway significantly decrease leukemic cell survival. The recent advances in this field focus on the latter part of the last decade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wataru Sakamoto, Nicolas Coant, Daniel Canals, Lina M. Obeid, Yusuf A. Hannun
JOURNAL OF LIPID RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Wataru Sakamoto, Daniel Canals, Silvia Salamone, Janet Allopenna, Christopher J. Clarke, Justin Snider, Lina M. Obeid, Yusuf A. Hannun
JOURNAL OF LIPID RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Mohamed F. Salama, Mengling Liu, Christopher J. Clarke, Mel Pilar Espaillat, John D. Haley, Ting Jin, Daifeng Wang, Lina M. Obeid, Yusuf A. Hannun
Article
Multidisciplinary Sciences
Guangtao Li, Shinako Kakuda, Pavana Suresh, Daniel Canals, Silvia Salamone, Erwin London
Article
Biochemistry & Molecular Biology
Daniel Canals, Silvia Salamone, Bruno Jaime Santacreu, Erika Nemeth, Daniel Aguilar, Maria Jose Hernandez-Corbacho, Mohamad Adada, Daniela I. Staquicini, Wadih Arap, Renata Pasqualini, John Haley, Lina M. Obeid, Yusuf A. Hannun
Article
Cell Biology
Sarah Alsamman, Stephanie A. Christenson, Amy Yu, Nadia M. E. Ayad, Meghan S. Mooring, Joe M. Segal, Jimmy Kuang-Hsien Hu, Johanna R. Schaub, Steve S. Ho, Vikram Rao, Megan M. Marlow, Scott M. Turner, Mai Sedki, Lorena Pantano, Sarani Ghoshal, Diego Dos Santos Ferreira, Hsiao-Yen Ma, Caroline C. Duwaerts, Regina Espanol-Suner, Lan Wei, Benjamin Newcomb, Izolda Mileva, Daniel Canals, Yusuf A. Hannun, Raymond T. Chung, Aras N. Mattis, Bryan C. Fuchs, Andrew M. Tager, Dean Yimlamai, Valerie M. Weaver, Alan C. Mullen, Dean Sheppard, Jennifer Y. Chen
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Article
Cell Biology
Magali Trayssac, Christopher J. Clarke, Jeffrey L. Stith, Justin M. Snider, Naomi Newen, Christopher R. Gault, Yusuf A. Hannun, Lina M. Obeid
Summary: Senescence is an antiproliferative mechanism that can suppress tumor development and be induced by oncogenes like genes of the Ras family. Targeting SK1 could potentially enhance oncogene-induced senescence by increasing VLC Cer downstream of CerS2.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Daniel Canals, Silvia Salamone, Bruno Jaime Santacreu, Daniel Aguilar, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Meaghan Greene, Erika Nemeth, John D. Haley, Lina M. Obeid, Yusuf A. Hannun
Summary: The study revealed that low doses of the chemotherapeutic compound doxorubicin result in dysregulation of cytoskeletal proteins, enhancing cancer cell migration, which could explain the reported effects of doxorubicin worsening cancer metastasis in animal models.
Editorial Material
Medicine, General & Internal
Daniel Canals
Article
Biochemistry & Molecular Biology
Meaghan Greene, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Daniel Canals
Summary: The role of ceramide in biological functions has been mainly studied by measuring its elevation in the total cell lysate using LC-MS. However, it is now recognized that ceramide in different subcellular organelles regulates specific functions. In the plasma membrane, even though the changes in ceramide levels may be a small fraction of the total cellular ceramide, they play a critical role in cell signaling. Currently, there are no efficient techniques to quantify ceramide specifically in the plasma membrane. This study presents a novel method to measure ceramide mass in the plasma membrane, allowing for investigation of sphingolipid compartmentalization and function.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Oncology
Samia Mohammed, Achraf A. Shamseddine, Benjamin Newcomb, Ronald S. Chavez, Tyler D. Panzner, Allen H. Lee, Daniel Canals, Chioma M. Okeoma, Christopher J. Clarke, Yusuf A. Hannun
Summary: Sublethal doses of Doxorubicin induce increased migration and invasion in cancer cells, independent of EMT and cancer stem cell population. Activation of SFKs, including Fyn, Yes, and Src, partly in a p53 and ATR-dependent manner, mediates these effects. Inhibiting SFKs with Dasatinib offers a potential therapeutic strategy to mitigate local invasion.
BREAST CANCER RESEARCH
(2021)
Article
Literature, American
Pedro Garcia-Caro
EARLY AMERICAN LITERATURE
(2018)