In situproduction of therapeutic monoclonal antibodies

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

(2014) Raquel P Deering et al.   Expert Opinion on Drug Delivery

The maturation of antibody technology for the HIV epidemic

(2014) Wendy R Winnall et al.   IMMUNOLOGY AND CELL BIOLOGY

Antibody Phage Display: Technique and Applications

(2014) Christoph M. Hammers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

The promise and challenge of high-throughput sequencing of the antibody repertoire

(2014) George Georgiou et al.   NATURE BIOTECHNOLOGY

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

(2014) E-Chiang Lee et al.   NATURE BIOTECHNOLOGY

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

(2014) Alejandro B Balazs et al.   NATURE MEDICINE

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice

(2014) C. Deal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy

(2013) Mario Mietzsch et al.   HUMAN GENE THERAPY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Broad protection against influenza infection by vectored immunoprophylaxis in mice

(2013) Alejandro B Balazs et al.   NATURE BIOTECHNOLOGY

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

(2013) Sangeetha Hareendran et al.   REVIEWS IN MEDICAL VIROLOGY

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

(2013) Kar Muthumani et al.   Human Vaccines & Immunotherapeutics

Engineering antibodies by yeast display

(2012) Eric T. Boder et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Manufacturing and Regulatory Strategies for Clinical AAV2-hRPE65

(2012) J. Fraser Wright et al.   CURRENT GENE THERAPY

Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial

(2012) D Gaudet et al.   GENE THERAPY

AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior

(2012) Jonathan B. Rosenberg et al.   HUMAN GENE THERAPY

Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer’s Disease Mouse Model

(2012) Junling Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

Antibody gene transfer for HIV immunoprophylaxis

(2012) Alejandro B Balazs et al.   NATURE IMMUNOLOGY

Human Anti-CCR4 Minibody Gene Transfer for the Treatment of Cutaneous T-Cell Lymphoma

(2012) Thomas Han et al.   PLoS One

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation

(2012) M. J. Hicks et al.   Science Translational Medicine

Adeno-associated virus-mediated anti-DR5 chimeric antibody expression suppresses human tumor growth in nude mice

(2011) Fujia Lv et al.   CANCER LETTERS

Persistent Suppression of Ocular Neovascularization with Intravitreal Administration of AAVrh.10 Coding for Bevacizumab

(2011) Yanxiong Mao et al.   HUMAN GENE THERAPY

Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results

(2011) Terence R. Flotte et al.   HUMAN GENE THERAPY

Large-scale recombinant adeno-associated virus production

(2011) R. M. Kotin   HUMAN MOLECULAR GENETICS

2A Peptide-based, Lentivirus-mediated Anti-death Receptor 5 Chimeric Antibody Expression Prevents Tumor Growth in Nude Mice

(2011) Meng Li et al.   MOLECULAR THERAPY

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concise Review: Mesenchymal Stem Cell Tumor-Homing: Detection Methods in Disease Model Systems

(2011) Michaela R. Reagan et al.   STEM CELLS

Persistent expression of biologically active anti-HER2 antibody by AAVrh.10-mediated gene transfer

(2010) G Wang et al.   CANCER GENE THERAPY

Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge

(2010) T J Van Blarcom et al.   GENE THERAPY

Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system

(2010) M Compte et al.   GENE THERAPY

AAVrh.10-mediated genetic delivery of bevacizumab to the pleura to provide local anti-VEGF to suppress growth of metastatic lung tumors

(2010) M Watanabe et al.   GENE THERAPY

In Vitro and In Vivo Characterization of MicroRNA-Targeted Alphavirus Replicon and Helper RNAs

(2010) K. I. Kamrud et al.   JOURNAL OF VIROLOGY

Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody

(2010) A. Joseph et al.   JOURNAL OF VIROLOGY

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy

(2009) X Liu et al.   CANCER GENE THERAPY

A GUTLESS ADENOVIRAL VECTOR EXPRESSING FULL-LENGTH ANTI-Her2 ANTIBODY

(2009) Ming-Hong Jiang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Genetic Delivery of Bevacizumab to Suppress Vascular Endothelial Growth Factor-Induced High-Permeability Pulmonary Edema

(2009) Masaki Watanabe et al.   HUMAN GENE THERAPY

Large-Scale Adeno-Associated Viral Vector Production Using a Herpesvirus-Based System Enables Manufacturing for Clinical Studies

(2009) Nathalie Clément et al.   HUMAN GENE THERAPY

Adenovirus-Mediated Delivery of an Anti-V Antigen Monoclonal Antibody Protects Mice against a Lethal Yersinia pestis Challenge

(2009) C. Sofer-Podesta et al.   INFECTION AND IMMUNITY

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Vision 1 Year after Gene Therapy for Leber's Congenital Amaurosis

(2009) Artur V. Cideciyan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies

(2009) Richard T. Frank et al.   PLoS One

Growth inhibition of an established A431 xenograft tumor by a full-length anti-EGFR antibody following gene delivery by AAV

(2008) D T Ho et al.   CANCER GENE THERAPY

"Active" Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

(2008) E. Vigna et al.   CANCER RESEARCH

Gene Therapy Using Adeno-Associated Virus Vectors

(2008) S. Daya et al.   CLINICAL MICROBIOLOGY REVIEWS

Gene Delivery of the Murine Equivalent of Bevacizumab (Avastin), an Anti-Vascular Endothelial Growth Factor Monoclonal Antibody, to Suppress Growth of Human Tumors in Immunodeficient Mice

(2008) Masaki Watanabe et al.   HUMAN GENE THERAPY

Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart

(2008) Hua Su et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

(2008) C. Zuber et al.   JOURNAL OF GENERAL VIROLOGY

Long-term in vivo imaging of human angiogenesis: Critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels

(2008) Laura Sanz et al.   MICROVASCULAR RESEARCH

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Immunotherapy Using Gene-Modified Human Mesenchymal Stem Cells Loaded into Synthetic Extracellular Matrix Scaffolds

(2008) Marta Compte et al.   STEM CELLS

Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV

(2008) Davor Skaricic et al.   VIROLOGY

Genetically delivered antibody protects against West Nile virus

(2007) Alexander Pereboev et al.   ANTIVIRAL RESEARCH

Critical assessment of current adeno-associated viral vector production and quantification methods

(2007) Marc G. Aucoin et al.   BIOTECHNOLOGY ADVANCES

Rapid/Sustained Anti-anthrax Passive Immunity Mediated by Co-administration of Ad/AAV

(2007) Bishnu P De et al.   MOLECULAR THERAPY