Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

(2013) S. Wilgenhof et al.   ANNALS OF ONCOLOGY

Natural antibodies to nucleic acids

(2013) V. N. Buneva et al.   BIOCHEMISTRY-MOSCOW

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

Alphavirus Genome Delivery Occurs Directly at the Plasma Membrane in a Time- and Temperature-Dependent Process

(2013) R. Vancini et al.   JOURNAL OF VIROLOGY

RNA-Based Vaccination: Sending a Strong Message

(2013) David B. Weiner   MOLECULAR THERAPY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

(2013) Satoshi Uchida et al.   PLoS One

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Challenges and advances towards the rational design of mRNA vaccines

(2013) Charlotte Pollard et al.   TRENDS IN MOLECULAR MEDICINE

mRNA

(2013) Sandra Van Lint et al.   Human Vaccines & Immunotherapeutics

A novel, disruptive vaccination technology

(2013) Karl-Josef Kallen et al.   Human Vaccines & Immunotherapeutics

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

(2012) Lucy W. Barrett et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lack of Interference with Immunogenicity of a Chimeric Alphavirus Replicon Particle-Based Influenza Vaccine by Preexisting Antivector Immunity

(2012) Yasushi Uematsu et al.   Clinical and Vaccine Immunology

A DNA-Based Candidate HIV Vaccine Delivered viaIn VivoElectroporation Induces CD4 Responses toward the α4β7-Binding V2 Loop of HIV gp120 in Healthy Volunteers

(2012) Jakub Kopycinski et al.   Clinical and Vaccine Immunology

Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins

(2012) Juliane W. Schott et al.   CURRENT GENE THERAPY

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

(2012) Mariola Fotin-Mleczek et al.   JOURNAL OF GENE MEDICINE

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

(2012) Yuan Zhang et al.   MOLECULAR THERAPY

Systemic Delivery of Modified mRNA Encoding Herpes Simplex Virus 1 Thymidine Kinase for Targeted Cancer Gene Therapy

(2012) Yuhua Wang et al.   MOLECULAR THERAPY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

(2012) Rachel L Graham et al.   NATURE MEDICINE

Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses

(2012) Daniel X. Johansson et al.   PLoS One

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

RNA-based vaccines

(2012) Jeffrey B. Ulmer et al.   VACCINE

Clinical Applications of DNA Vaccines: Current Progress

(2011) B. Ferraro et al.   CLINICAL INFECTIOUS DISEASES

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

mRNA vaccination as a safe approach for specific protection from type I allergy

(2011) Richard Weiss et al.   Expert Review of Vaccines

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Engineering Dendritic Cells to Enhance Cancer Immunotherapy

(2011) Jeanette E Boudreau et al.   MOLECULAR THERAPY

Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles

(2011) Nadia Ruthardt et al.   MOLECULAR THERAPY

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

(2011) Federico Perche et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

PEGylation Improves Nanoparticle Formation and Transfection Efficiency of Messenger RNA

(2011) Senta Üzgün et al.   PHARMACEUTICAL RESEARCH

In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers

(2011) Sandhya Vasan et al.   PLoS One

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Particle size and activation threshold: a new dimension of danger signaling

(2010) L. Rettig et al.   BLOOD

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

Immunologic Basis of Vaccine Vectors

(2010) Margaret A. Liu   IMMUNITY

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells

(2010) S. Zou et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of 5′- and 3′-untranslated regions of mRNAs in human diseases

(2009) Sangeeta Chatterjee et al.   BIOLOGY OF THE CELL

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers

(2009) David I. Bernstein et al.   VACCINE

Therapeutic and prophylactic applications of alphavirus vectors

(2008) Gregory J. Atkins et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Phenotypic and Functional Analysis of Dendritic Cells and Clinical Outcome in Patients With High-Risk Melanoma Treated With Adjuvant Granulocyte Macrophage Colony-Stimulating Factor

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Design opportunities for actively targeted nanoparticle vaccines

(2008) Tarek M Fahmy et al.   Nanomedicine

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS