Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

(2015) Akwasi Agyeman et al.   Oncotarget

Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

(2014) Ulrike Leurs et al.   ACS Chemical Biology

Epigenetic drugs against cancer: an evolving landscape

(2014) Antonella Di Costanzo et al.   ARCHIVES OF TOXICOLOGY

FOXA1 antagonizes EZH2-mediated CDKN2A repression in carcinogenesis

(2014) Yu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling

(2014) Farida F. Khan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ASXL genes and RUNX1: an intimate connection?

(2014) K. H. Metzeler   BLOOD

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations

(2014) J.-B. Micol et al.   BLOOD

Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

(2014) Guillermo Montalbán Bravo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Epigenetic modifications as potential therapeutic targets in age-related macular degeneration and diabetic retinopathy

(2014) Faith A.A. Kwa et al.   DRUG DISCOVERY TODAY

The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused toKAT6Ain therapy-related acute myeloid leukemia with t(8;19)(p11;q13)

(2014) Yoshiaki Chinen et al.   GENES CHROMOSOMES & CANCER

Additional sex combs-likefamily genes are required for normal cardiovascular development

(2014) Andrea L. McGinley et al.   GENESIS

Structural and Functional Insights into the Human Börjeson-Forssman-Lehmann Syndrome-associated Protein PHF6

(2014) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

(2014) Chia-Han Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromodomain Antagonists That Target the Polycomb-Group Methyllysine Reader Protein Chromobox Homolog 7 (CBX7)

(2014) Chakravarthi Simhadri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

(2014) Li Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of Jumonji-type oxygenases in human disease

(2014) Catrine Johansson et al.   Epigenomics

Integrated analysis of germline and somatic variants in ovarian cancer

(2014) Krishna L. Kanchi et al.   Nature Communications

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function

(2014) S. M. Gough et al.   Cancer Discovery

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

(2014) Brianna J. Klein et al.   Cell Reports

EZH2: biology, disease and structure-based drug discovery

(2013) Jin-zhi Tan et al.   ACTA PHARMACOLOGICA SINICA

Delineation of a new chromosome 20q11.2 duplication syndrome including theASXL1gene

(2013) Magali Avila et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis

(2013) Ui-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Investigations of the Nickel-Induced Inhibition of Truncated Constructs of the JMJD2 Family of Histone Demethylases Using X-ray Absorption Spectroscopy

(2013) Nitai Charan Giri et al.   BIOCHEMISTRY

Diverse functions of PHD fingers of the MLL/KMT2 subfamily

(2013) Muzaffar Ali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The genetic basis of myelodysplasia and its clinical relevance

(2013) M. Cazzola et al.   BLOOD

Functional and cancer genomics of ASXL family members

(2013) M Katoh   BRITISH JOURNAL OF CANCER

Fusion of the additional sex combs like 1 and teashirt zinc finger homeobox 2 genes resulting from ider(20q) aberration in a patient with myelodysplastic syndrome

(2013) Jana Brezinova et al.   BRITISH JOURNAL OF HAEMATOLOGY

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

Multifaceted role of EZH2 in breast and prostate tumorigenesis

(2013) Gauri Deb et al.   Epigenetics

Epigenetic regulation of estrogen signaling in breast cancer

(2013) Eric Hervouet et al.   Epigenetics

Cancer genomics identifies disrupted epigenetic genes

(2013) Laia Simó-Riudalbas et al.   HUMAN GENETICS

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

(2013) Daichi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear receptors and chromatin: an inducible couple

(2013) Raffaella Maria Gadaleta et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

FGF Receptors: Cancer Biology and Therapeutics

(2013) Masaru Katoh et al.   MEDICINAL RESEARCH REVIEWS

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

(2013) Cristina Balbás-Martínez et al.   NATURE GENETICS

Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets

(2013) Hsiao-Lei Lai et al.   PLoS One

Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5

(2013) Alexander Lemak et al.   PLoS One

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

(2013) Tobias Klein et al.   ACS Medicinal Chemistry Letters

The importance of the intrauterine environment in shaping the human neonatal epigenome

(2013) Boris Novakovic et al.   Epigenomics

Dido3 PHD Modulates Cell Differentiation and Division

(2013) Jovylyn Gatchalian et al.   Cell Reports

Expanding our knowledge of conditions associated with the ASXL gene family

(2013) Bianca Russell et al.   Genome Medicine

De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome

(2013) Matthew N Bainbridge et al.   Genome Medicine

Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger

(2012) Elise K. Wagner et al.   BIOCHEMISTRY

Targeting hedgehog in hematologic malignancy

(2012) D. A. Irvine et al.   BLOOD

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

(2012) Omar Abdel-Wahab et al.   CANCER CELL

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

The HARE-HTH and associated domains

(2012) L. Aravind et al.   CELL CYCLE

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

(2012) Véronique Gelsi-Boyer et al.   Journal of Hematology & Oncology

Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA

(2012) Lei Liu et al.   JOURNAL OF STRUCTURAL BIOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

Emerging Anatomy of the BAP1 Tumor Suppressor System

(2012) A. E. White et al.   SCIENCE

Many keys to push: diversifying the ‘readership’ of plant homeodomain fingers

(2011) Yuanyuan Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Autism spectrum disorders and autistic traits: A decade of new twin studies

(2011) Angelica Ronald et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes

(2011) Gaylor Boulay et al.   BIOCHEMICAL JOURNAL

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

(2011) K. H. Metzeler et al.   BLOOD

De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

(2011) Alexander Hoischen et al.   NATURE GENETICS

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

(2011) Meng Li et al.   NATURE GENETICS

Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability

(2011) David S. Williams et al.   PLoS One

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation

(2010) Hong Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Additional Sex Comb-like (ASXL) Proteins 1 and 2 Play Opposite Roles in Adipogenesis via Reciprocal Regulation of Peroxisome Proliferator-activated Receptor γ

(2010) Ui-Hyun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

(2010) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Epigenetics and cardiovascular disease

(2010) José M. Ordovás et al.   Nature Reviews Cardiology

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

(2010) Weijun Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomics by Mass Spectrometry: Approaches, Advances, and Applications

(2009) John R. Yates et al.   Annual Review of Biomedical Engineering

Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia

(2009) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma

(2009) Shingo Nakahata et al.   GENES CHROMOSOMES & CANCER

The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1

(2009) Yuichi J. Machida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Functional Conservation of Asxl2, a Murine Homolog for the Drosophila Enhancer of Trithorax and Polycomb Group Gene Asx

(2009) Heather A. Baskind et al.   PLoS One

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Chromatin proteomics and epigenetic regulatory circuits

(2008) Clemens Bönisch et al.   Expert Review of Proteomics

Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression

(2008) Luigi Scotto et al.   GENES CHROMOSOMES & CANCER

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

(2008) Lindsey A. Baker et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE