标题
Drugs acting on homeostasis: challenging cancer cell adaptation
作者
关键词
-
出版物
Expert Review of Anticancer Therapy
Volume 15, Issue 12, Pages 1405-1417
出版商
Informa UK Limited
发表日期
2015-11-03
DOI
10.1586/14737140.2015.1095095
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment
- (2015) Spiros A. Vlahopoulos et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis
- (2015) Katharina Bluemlein et al. Oncotarget
- Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
- (2015) Veronica Martinez-Marignac et al. Oncotarget
- Cross talk Initiated by Endothelial Cells Enhances Migration and Inhibits Anoikis of Squamous Cell Carcinoma Cells through STAT3/Akt/ERK Signaling
- (2015) Kathleen G. Neiva et al. NEOPLASIA
- Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
- (2015) Ruo-Chia Tseng et al. NEOPLASIA
- Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT
- (2014) H. S. Hochster et al. ANNALS OF ONCOLOGY
- RETRACTED: Inhibition of PKM2 sensitizes triple-negative breast cancer cells to doxorubicin
- (2014) Feng Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention
- (2014) Beshay N.M. Zordoky et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis
- (2014) S. Chen et al. BLOOD
- Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study
- (2014) S. Bringhen et al. BLOOD
- Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia
- (2014) Amy L. Samuels et al. BRITISH JOURNAL OF HAEMATOLOGY
- Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
- (2014) A. Layani-Bazar et al. CANCER RESEARCH
- Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
- (2014) Atsushi Umemura et al. Cell Metabolism
- New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy
- (2014) Spiros Vlahopoulos et al. CURRENT DRUG TARGETS
- Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- (2014) Chun-Han Hou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin
- (2014) Irene Brana et al. INVESTIGATIONAL NEW DRUGS
- 5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors
- (2014) Keith R. Laderoute et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin
- (2014) Jenelle Govender et al. JOURNAL OF PINEAL RESEARCH
- Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
- (2014) Liang Lv et al. MEDICAL ONCOLOGY
- WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
- (2014) Elin J Ekström et al. Molecular Cancer
- Haematopoietic stem cells require a highly regulated protein synthesis rate
- (2014) Robert A. J. Signer et al. NATURE
- 5-Fluorouracil affects assembly of stress granules based on RNA incorporation
- (2014) Christian Kaehler et al. NUCLEIC ACIDS RESEARCH
- Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells
- (2014) Pei-Ching Chang et al. PLoS One
- Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo
- (2014) Yongxian Zhuang et al. PLoS One
- Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARγ Agonism as Preventive Pharmacological Approach
- (2014) Matteo Zanardelli et al. PLoS One
- Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
- (2014) X. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function
- (2014) Ubaldo Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells
- (2013) Shaobin Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- In Vitro Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages
- (2013) Yusuke Kono et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
- (2013) Albrecht Stenzinger et al. BMC CANCER
- Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation
- (2013) Y Zhang et al. BRITISH JOURNAL OF CANCER
- Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells
- (2013) Haitao Zhu et al. Cancer Cell International
- Activation of NFkB is a novel mechanism of pro-survival activity of glucocorticoids in breast cancer cells
- (2013) Shagufta Khan et al. CANCER LETTERS
- Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair
- (2013) P. J. Halvey et al. CANCER RESEARCH
- Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
- (2013) E. M. Dijkgraaf et al. CANCER RESEARCH
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- (2013) Anu Kauppinen et al. CELLULAR SIGNALLING
- Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
- (2013) S. M. Hadad et al. Clinical & Translational Oncology
- Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
- (2013) B. Li et al. CLINICAL CANCER RESEARCH
- Peroxisome Proliferator Activated Receptor α Ligands as Anticancer Drugs Targeting Mitochondrial Metabolism
- (2013) Maja Grabacka et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin
- (2013) E. M. Moore et al. DIABETES CARE
- Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway
- (2013) Zhuling Qu et al. Diagnostic Pathology
- Mammalian target of rapamycin inhibitor rapamycin enhances anti-leukemia effect of imatinib on Ph+acute lymphoblastic leukemia cells
- (2013) Xi Yang et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
- (2013) Yedong Cheng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: Relevance of p53 and its clinical implications
- (2013) Benigno C. Valdez et al. EXPERIMENTAL HEMATOLOGY
- Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma
- (2013) Li Zhang et al. HEPATOLOGY
- Myc inhibition impairs autophagosome formation
- (2013) Pearl P. C. Toh et al. HUMAN MOLECULAR GENETICS
- Glucose plays a main role in human fibroblasts adaptation to hypoxia
- (2013) Alessandra Baracca et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Clinical Advances in Molecular Biomarkers for Cancer Diagnosis and Therapy
- (2013) Seema Sethi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phenotypic Identification of the Redox Dye Methylene Blue as an Antagonist of Heat Shock Response Gene Expression in Metastatic Melanoma Cells
- (2013) Angela Davis et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity
- (2013) Leibo Xu et al. JOURNAL OF HEPATOLOGY
- Redox-proteomic analysis of doxorubicin resistance-induced altered thiol activity in uterine carcinoma
- (2013) Szu-Ting Lin et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner
- (2013) M. Cerezo et al. MOLECULAR CANCER THERAPEUTICS
- Androgens Upregulate Cdc25C Protein by Inhibiting Its Proteasomal and Lysosomal Degradation Pathways
- (2013) Yu-Wei Chou et al. PLoS One
- Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells
- (2013) Laura M. Epple et al. PLoS One
- Calcium Channels and Prostate Cancer
- (2013) George Shapovalov et al. Recent Patents on Anti-Cancer Drug Discovery
- SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells
- (2013) A Scuto et al. Cell Death & Disease
- Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
- (2013) Baoxu Pang et al. Nature Communications
- Metabolic changes in cancer: beyond the Warburg effect
- (2012) W. Wu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Interleukin-6
- (2012) Nikki A. Delk et al. Autophagy
- Singularities of calcium signaling in effector T-lymphocytes
- (2012) Virginie Robert et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy
- (2012) Giorgio Santoni et al. BRITISH JOURNAL OF PHARMACOLOGY
- AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
- (2012) C.-W. Lee et al. CANCER RESEARCH
- An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma
- (2012) Huiqiong Lin et al. EXPERIMENTAL CELL RESEARCH
- Pioglitazone protects against cisplatin induced nephrotoxicity in rats and potentiates its anticancer activity against human renal adenocarcinoma cell lines
- (2012) Mona F. Mahmoud et al. FOOD AND CHEMICAL TOXICOLOGY
- Small heat shock proteins in cancer therapy and prognosis
- (2012) Amina Zoubeidi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen
- (2012) Haitao Bai et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)
- (2012) Nathan W. Werneburg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calcium Channels and Pumps in Cancer: Changes and Consequences
- (2012) Gregory R. Monteith et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucocorticoid and proteasome inhibitor impact on the leukemic lymphoblast: Multiple, diverse signals converging on a few key downstream regulators
- (2012) George I. Lambrou et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport
- (2012) Naveen Kumar Vishvakarma et al. MOLECULAR CARCINOGENESIS
- The Expression of the Endoplasmic Reticulum Stress Sensor BiP/GRP78 Predicts Response to Chemotherapy and Determines the Efficacy of Proteasome Inhibitors in Diffuse Large B-Cell Lymphoma
- (2011) Ana Mozos et al. AMERICAN JOURNAL OF PATHOLOGY
- Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107)
- (2011) Sergio Amadori et al. BRITISH JOURNAL OF HAEMATOLOGY
- Simultaneous inhibition of the constitutively activated nuclear factor κB and of the Interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells
- (2011) Natalia Malara et al. CELL CYCLE
- Ultrastructural changes in the rat kidney after single dose of cyclophosphamide—Possible roles for peroxisome proliferation and lysosomal dysfunction in cyclophosphamide-induced renal damage
- (2011) Premila Abraham et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Combination of ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, and cisplatin enhances the inhibition of growth of human ovarian cancers
- (2011) Yoshihito Yokoyama et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
- (2011) J Asano et al. LEUKEMIA
- Squamous Cell Carcinoma Antigen 1 Promotes Caspase-8-Mediated Apoptosis in Response to Endoplasmic Reticulum Stress While Inhibiting Necrosis Induced by Lysosomal Injury
- (2011) E. Ullman et al. MOLECULAR AND CELLULAR BIOLOGY
- Antidiabetic Drug Metformin Induces Apoptosis in Human MCF Breast Cancer via Targeting ERK Signaling
- (2011) Ahmed Malki et al. ONCOLOGY RESEARCH
- Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors
- (2011) Andreas Peyrl et al. PEDIATRIC BLOOD & CANCER
- TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells
- (2010) Vijay Ramakrishnan et al. AMERICAN JOURNAL OF HEMATOLOGY
- BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia
- (2010) Nan Jiang et al. EXPERIMENTAL HEMATOLOGY
- Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation
- (2010) Chunyang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Novel, Proteasome-Independent NF- B Inhibitor V1810 Induces Apoptosis and Cell Cycle Arrest in Multiple Myeloma and Overcomes NF- B-Mediated Drug Resistance
- (2010) F. G. Meinel et al. MOLECULAR CANCER THERAPEUTICS
- Vinblastine Induces Acute, Cell Cycle Phase–Independent Apoptosis in Some Leukemias and Lymphomas and Can Induce Acute Apoptosis in Others when Mcl-1 Is Suppressed
- (2010) Bethany L. Salerni et al. MOLECULAR CANCER THERAPEUTICS
- mTOR signaling in glioblastoma: lessons learned from bench to bedside
- (2010) D. Akhavan et al. NEURO-ONCOLOGY
- Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue-specific intervention possible?
- (2009) John A. Copland et al. BIOESSAYS
- mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
- (2009) David A. Guertin et al. CANCER CELL
- Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
- (2009) H. A. Hirsch et al. CANCER RESEARCH
- Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents
- (2009) T Sánchez-Pérez et al. CELL DEATH AND DIFFERENTIATION
- Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
- (2009) Cristian Bellodi et al. JOURNAL OF CLINICAL INVESTIGATION
- Transcriptional Integration of TLR2 and TLR4 Signaling at the NCoR Derepression Checkpoint
- (2009) Wendy Huang et al. MOLECULAR CELL
- PPAR blocks glucocorticoid receptor -mediated transactivation but cooperates with the activated glucocorticoid receptor for transrepression on NF- B
- (2009) N. Bougarne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma
- (2008) A. Zollinger et al. BLOOD
- Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
- (2008) E. Hulleman et al. BLOOD
- Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation
- (2008) Nicolas Fissolo et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Bortezomib-Resistant Nuclear Factor- B Activity in Multiple Myeloma Cells
- (2008) S. Markovina et al. MOLECULAR CANCER RESEARCH
- Bortezomib is ineffective in an orthotopic mouse model of pancreatic adenocarcinoma
- (2008) A. Marten et al. MOLECULAR CANCER THERAPEUTICS
- Calcium signaling and T-type calcium channels in cancer cell cycling
- (2008) James T Taylor et al. WORLD JOURNAL OF GASTROENTEROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now