Article
Biochemistry & Molecular Biology
Min Zhang, Xiaoyu Duan, Lu Wang, Jing Wen, Pingfei Fang
Summary: Mild hypothermia induces apoptotic cell death in cancer cells, and the underlying mechanism may be related to the activation of endoplasmic reticulum unfolded protein response (UPRER). Lung adenocarcinoma cells are resistant to hypothermia-induced cell death due to defective UPRER activation. The expression of heat shock factor 1 (HSF1) plays a regulatory role in this process by activating UPRER to promote apoptotic cell death. Furthermore, activating UPRER enhances the cytotoxicity of chemotherapy drugs cisplatin in cancer cells, suggesting its potential in combating chemoresistance.
Article
Endocrinology & Metabolism
Jiaxi Song, Qicheng Ni, Jiajun Sun, Jing Xie, Jianmin Liu, Guang Ning, Weiqing Wang, Qidi Wang
Summary: This study found that the differentiated state of senescent human beta cells is altered, possibly representing a crucial step in the pathogenesis of age-related beta cell failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Kai Huang, Tao Zhang, Wenjun Zhang, Yue Gu, Pan Yu, Lanqing Sun, Zhiwei Liu, Tao Wang, Ying Xu
Summary: Mistimed food intake disrupts circadian rhythms in peripheral tissues and increases the risk of metabolic diseases. This study establishes a 10-generation mouse model to investigate the effects of continuous daytime-restricted feeding (DRF). The results show that mistimed food intake leads to cumulative effects on ER stress sensitivity over generations in mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuanzhong Wang, Shiuan Chen
Summary: Estrogen activates the unfolded protein response (UPR) to increase glucose uptake and reprogram glucose metabolism in ER+ breast cancer cells. Thioredoxin-interacting protein (TXNIP) is a crucial regulator of glucose metabolism. Estrogen increases glucose uptake and reprograms glucose metabolism by suppressing TXNIP expression.
Article
Oncology
Nora Pallmann, Ke Deng, Marte Livgard, Martina Tesikova, Yixin Jin, Nicolai Sebastian Frengen, Nermin Kahraman, Hamada M. Mokhlis, Bulent Ozpolat, Wanja Kildal, Havard Emil Danielsen, Ladan Fazli, Paul S. Rennie, Partha P. Banerjee, Aykut Uren, Yang Jin, Omer F. Kuzu, Fahri Saatcioglu
Summary: In prostate cancer cells, activating transcription factor 4 (ATF4) exclusively activates gene expression involved in the mitochondrial (m1C) one-carbon cycle, not the cytoplasmic (c1C) cycle; knockdown of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibits prostate cancer cell growth significantly. This suggests that the m1C cycle plays a key role in prostate cancer progression and may serve as a potential biomarker and therapeutic target.
Article
Multidisciplinary Sciences
Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E. Steele, Sarah Maguire, Rohinton Tarapore, Joshua E. Allen, Sandra Van Schaeybroeck, Karl T. Butterworth, Kevin Prise, Joe M. O'Sullivan, Suneil Jain, David J. Waugh, Ian G. Mills
Summary: The study demonstrated that ONC201 can enhance the radiation response of prostate cancer cells by suppressing the expression of cell cycle and DNA repair factors.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Zaili Yang, Yazhen Huo, Shixin Zhou, Jingya Guo, Xiaotu Ma, Tao Li, Congli Fan, Likun Wang
Summary: A hostile microenvironment in tumor tissues disrupts endoplasmic reticulum homeostasis and activates the unfolded protein response. The UPR component X-box binding protein 1 (XBP1) in cancer cells promotes the synthesis and secretion of cholesterol, which activates myeloid-derived suppressor cells (MDSCs) and causes immunosuppression. Inhibition of XBP1 or reduction of tumor cholesterol content significantly reduces MDSC abundance and triggers robust anti-tumor responses.
Article
Medicine, Research & Experimental
Asvin K. K. Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi
Summary: This study found that prion infection and prion-mimetic antibodies deplete PIKfyve, a phosphoinositide kinase controlling endolysosomal maturation, leading to endolysosomal hypertrophy and activation of lysosomal enzymes. This depletion of PIKfyve is mediated by acyltransferases zDHHC9 and zDHHC21, whose topology is disturbed by prion infection, resulting in vacuolation in prion diseases. Restoring PIKfyve levels through different methods can suppress prion-induced vacuolation and restore lysosomal homeostasis.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dana Goldberg, Meital Charni-Natan, Nufar Buchshtab, Meirav Bar-Shimon, Ido Goldstein
Summary: This study reveals the cooperative mechanism between glucagon and glucocorticoids in regulating glucose production. The findings demonstrate that a dual treatment with these hormones leads to synergistic gene induction and a tailored transcriptional response to fasting. This cooperative mechanism is based on enhanced enhancer activation and facilitated binding of the glucocorticoid receptor.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Zhenbang Zhu, Panrao Liu, Lili Yuan, Zhengmin Lian, Danhe Hu, Xiaohui Yao, Xiangdong Li
Summary: PRRSV infection induces UPR before the interferon response, leading to enhanced expression of interferon and interferon-related genes to suppress the virus replication; UPR induction promotes PKR expression, which is correlated with reduced PRRSV replication; Furthermore, tunicamycin stimulation and PKR overexpression activate NF-kappa B and interferon response, reinforcing the expression of type I interferons and proinflammatory cytokines to inhibit PRRSV.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mercedes Viettri, Jose L. Zambrano, Romel Rosales, Gerson I. Caraballo, Ana Lorena Gutierrez-Escolano, Juan E. Ludert
Summary: The study investigated whether infection with dengue and Zika viruses triggers a Golgi stress response in vertebrate and mosquito cells, showing that these viruses induce expansion of the Golgi complex and activation of the TFE3 pathway.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Wei Fang, Qiuchi Chen, Jiamin Li, Yongtao Liu, Zengqi Zhao, Yanan Shen, Kangsen Mai, Qinghui Ai
Summary: The study found that ER stress disrupted lipid metabolism and increased inflammation in the intestine and isolated intestinal cells of large yellow croaker, potentially leading to novel therapies for addressing lipid dysregulation and inflammation in the intestines of fish and humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Corinna Seliger, Anne-Louise Meyer, Verena Leidgens, Lisa Rauer, Sylvia Moeckel, Birgit Jachnik, Judith Proske, Katja Dettmer, Tanja Rothhammer-Hampl, Leon D. Kaulen, Markus J. Riemenschneider, Peter J. Oefner, Marina Kreutz, Nils-Ole Schmidt, Marsha Merrill, Martin Uhl, Kathrin Renner, Arabel Vollmann-Zwerenz, Martin Proescholdt, Peter Hau
Summary: A study found that brain tumor-initiating cells of different subtypes have different responses to metabolic intervention. Mesenchymal cells tend to rely on glycolysis and are less responsive to the metabolic inhibitor metformin; while proneural cells are more responsive to oxidative phosphorylation inhibition and have a lower invasive potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ankit Patel, Masanori Oshi, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: The study found a correlation between the unfolded protein response (UPR) and hepatocellular carcinoma (HCC) in terms of carcinogenesis, cancer progression, and patient survival. The UPR score can serve as a biomarker for predicting cancer progression and patient prognosis in HCC.
Article
Endocrinology & Metabolism
Paul G. Weightman Potter, Sam J. Washer, Aaron R. Jeffries, Janet E. Holley, Nick J. Gutowski, Emma L. Dempster, Craig Beall
Summary: The study found that exposure of human astrocytes to transient low glucose triggers activation of genes related to endoplasmic reticulum stress, while after recurrent low glucose exposure, the activation of stress-related genes decreases, suggesting attenuated endoplasmic reticulum stress. This may be a result of successful metabolic adaptation, better preserving intracellular energy levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Oncology
Rebecca D. Dodd
Article
Oncology
Mohit Sachdeva, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, David G. Kirsch
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Biochemistry & Molecular Biology
R. D. Dodd, M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, D. G. Kirsch
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Multidisciplinary Sciences
Mark Oldham, Paul Yoon, Zak Fathi, Wayne F. Beyer, Justus Adamson, Leihua Liu, David Alcorta, Wenle Xia, Takuya Osada, Congxiao Liu, Xiao Y. Yang, Rebecca D. Dodd, James E. Herndon, Boyu Meng, David G. Kirsch, H. Kim Lyerly, Mark W. Dewhirst, Peter Fecci, Harold Walder, Neil L. Spector
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Multidisciplinary Sciences
Jianguo Huang, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, David Van Mater, William C. Eward, Diana M. Cardona, Lixia Luo, Yan Ma, Omar M. Lopez, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Anupama Reddy, Sandeep S. Dave, Charles A. Gersbach, Rebecca D. Dodd, David G. Kirsch
NATURE COMMUNICATIONS
(2017)
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Oncology
Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg, Megan Bowman, Zachary Madaj, Julie Koeman, Elissa A. Boguslawski, Jamie Grit, Rebecca D. Dodd, Vadim Khachaturov, Diana M. Cardona, Mark Chen, David G. Kirsch, Flavio Maina, Rosanna Dono, Mary E. Winn, Carrie R. Graveel, Matthew R. Steensma
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Medicine, Research & Experimental
Mohit Sachdeva, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, Lixia Luo, Yan Ma, David Van Mater, Rebecca Gladdy, Dina C. Lev, Diana M. Cardona, David G. Kirsch
JOURNAL OF CLINICAL INVESTIGATION
(2014)
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Oncology
Rebecca D. Dodd, Jeffrey K. Mito, William C. Eward, Rhea Chitalia, Mohit Sachdeva, Yan Ma, Jordi Barretina, Leslie Dodd, David G. Kirsch
MOLECULAR CANCER THERAPEUTICS
(2013)
Article
Genetics & Heredity
Amanda Scherer, Victoria R. Stephens, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Vickie Knepper-Adrian, Rebecca D. Dodd
Article
Oncology
Rebecca D. Dodd, Amanda Scherer, Wesley Huang, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Kathleen A. Ashcraft, Victoria R. Stephens, Parisa Yousefpour, Soumen Saha, Vickie Knepper-Adrian, Warren Floyd, Mark Chen, Yan Ma, Eric M. Mastria, Diana M. Cardona, William C. Eward, Ashutosh Chilkoti, David G. Kirsch
CLINICAL CANCER RESEARCH
(2020)
Editorial Material
Genetics & Heredity
Angela C. Hirbe, Rebecca D. Dodd, Christine A. Pratilas
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Biochemistry & Molecular Biology
Wade R. Gutierrez, Jeffrey D. Rytlewski, Amanda Scherer, Grace A. Roughton, Nina C. Carnevale, Krisha Y. Vyas, Gavin R. McGivney, Qierra R. Brockman, Vickie Knepper-Adrian, Rebecca D. Dodd
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
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Oncology
Rebecca D. Dodd, Chang-Lung Lee, Tess Overton, Wesley Huang, William C. Eward, Lixia Luo, Yan Ma, Davis R. Ingram, Keila E. Torres, Diana M. Cardona, Alexander J. Lazar, David G. Kirsch
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Medicine, Research & Experimental
Katherine A. White, Vicki J. Swier, Jacob T. Cain, Jordan L. Kohlmeyer, David K. Meyerholz, Munir R. Tanas, Johanna Uthoff, Emily Hammond, Hua Li, Frank A. Rohret, Adam Goeken, Chun-Hung Chan, Mariah R. Leidinger, Shaikamjad Umesalma, Margaret R. Wallace, Rebecca D. Dodd, Karin Panzer, Amy H. Tang, Benjamin W. Darbro, Aubin Moutal, Song Cai, Wennan Li, Shreya S. Bellampalli, Rajesh Khanna, Christopher S. Rogers, Jessica C. Sieren, Dawn E. Quelle, Jill M. Weimer