Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function

Prediction of drug–ABC-transporter interaction — Recent advances and future challenges

(2015) Floriane Montanari et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate

(2015) Emmanuel Gonzales et al.   HEPATOLOGY

Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2

(2015) G. Engelmann et al.   PEDIATRICS

In Silico Identification and in Vitro Validation of Potential Cholestatic Compounds through 3D Ligand-Based Pharmacophore Modeling of BSEP Inhibitors

(2014) Tina Ritschel et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Autoimmune BSEP Disease: Disease Recurrence After Liver Transplantation for Progressive Familial Intrahepatic Cholestasis

(2014) Ralf Kubitz et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatobiliary transporters in drug-induced cholestasis: a perspective on the current identifying tools

(2014) Manuela de Lima Toccafondo Vieira et al.   Expert Opinion on Drug Metabolism & Toxicology

Transcriptional dynamics of bile salt export pump during pregnancy: Mechanisms and implications in intrahepatic cholestasis of pregnancy

(2014) Xiulong Song et al.   HEPATOLOGY

Improved Liver Function and Relieved Pruritus after 4-Phenylbutyrate Therapy in a Patient with Progressive Familial Intrahepatic Cholestasis Type 2

(2014) Sotaro Naoi et al.   JOURNAL OF PEDIATRICS

Confocal Imaging with a Fluorescent Bile Acid Analogue Closely Mimicking Hepatic Taurocholate Disposition

(2014) Tom De Bruyn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes

(2014) László Homolya et al.   PLoS One

The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP

(2013) Cyrina D van Beusekom et al.   BMC Veterinary Research

The Genetics of Complex Cholestatic Disorders

(2013) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Locking Intracellular Helices 2 and 3 Together Inactivates Human P-glycoprotein

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells

(2013) Tatehiro Kagawa et al.   JOURNAL OF GASTROENTEROLOGY

Analysis of Pseudoxanthoma Elasticum–Causing Missense Mutants of ABCC6 In Vivo ; Pharmacological Correction of the Mislocalized Proteins

(2013) Viola Pomozi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations

(2013) Carol J. Soroka et al.   MOLECULAR ASPECTS OF MEDICINE

Clinical application of transcriptional activators of bile salt transporters

(2013) Anna Baghdasaryan et al.   MOLECULAR ASPECTS OF MEDICINE

Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

(2013) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

(2013) Jenny M. Pedersen et al.   TOXICOLOGICAL SCIENCES

Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2

(2012) Takashi Misawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ABCMdb: A database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application

(2012) Gergely Gyimesi et al.   HUMAN MUTATION

Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2

(2012) Emmanuel Gonzales et al.   JOURNAL OF HEPATOLOGY

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

(2012) Tracy L. Marion et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The bile salt export pump (BSEP) in health and disease

(2012) Ralf Kubitz et al.   Clinics and Research in Hepatology and Gastroenterology

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

(2011) Eiichiro Ogimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Canalicular Bile Salt Export Pump BSEP (ABCB11) as a Potential Therapeutic Target

(2011) Bruno Stieger et al.   CURRENT DRUG TARGETS

Interaction of bile salts with rat canalicular membrane vesicles: Evidence for bile salt resistant microdomains

(2011) Christelle Guyot et al.   JOURNAL OF HEPATOLOGY

Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism

(2010) Paul A. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Measurement of Bile Salt Export Pump Transport Activities using a Fluorescent Bile Acid Derivative

(2010) Kana Yamaguchi et al.   Drug Metabolism and Pharmacokinetics

Differences in presentation and progression between severe FIC1 and BSEP deficiencies

(2010) Ludmila Pawlikowska et al.   JOURNAL OF HEPATOLOGY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy

(2010) Christiane Pauli-Magnus et al.   SEMINARS IN LIVER DISEASE

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

(2009) E. Kis et al.   DRUG METABOLISM AND DISPOSITION

De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: A novel mechanism of cholestasis

(2009) Verena Keitel et al.   HEPATOLOGY

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

(2009) Coen C. Paulusma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability

(2009) Richard H. Ho et al.   Pharmacogenetics and Genomics

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2

(2008) Kousei Ito et al.   FEBS LETTERS

Severe Bile Salt Export Pump Deficiency: 82 Different ABCB11 Mutations in 109 Families

(2008) Sandra S. Strautnieks et al.   GASTROENTEROLOGY

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

(2008) P H Dixon et al.   GUT

ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes

(2008) Manfred G. Ismair et al.   HEPATOLOGY

Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

(2008) Jane A. Byrne et al.   HEPATOLOGY

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II

(2008) Lin Wang et al.   HEPATOLOGY

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

(2008) S. Matsushima et al.   MOLECULAR PHARMACOLOGY

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

(2008) Yvonne Meier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells

(2007) Tatehiro Kagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY