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Current Challenges and Controversies in Drug-Induced Liver Injury

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The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury

(2012) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis

(2012) Fei Li et al.   JOURNAL OF LIPID RESEARCH

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Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

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(2011) Shannan Tujios et al.   Nature Reviews Gastroenterology & Hepatology

Cholestasis and the Role of Basolateral Efflux Pumps

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Application of Genomics for Identification of Systemic Toxicity Triggers Associated With VEGF-R Inhibitors

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(2010) Ann K Daly   PHARMACOGENOMICS

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

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(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

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Species-Specific and Age-Dependent Bile Acid Composition: Aspects on CYP8B and CYP4A Subfamilies in Bile Acid Biosynthesis

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Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

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Prediction and Identification of Drug Interactions with the Human ATP-Binding Cassette Transporter Multidrug-Resistance Associated Protein 2 (MRP2; ABCC2)

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