标题
Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 19, Issue 10, Pages 1397-1409
出版商
Informa Healthcare
发表日期
2015-09-16
DOI
10.1517/14728222.2015.1067303
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations
- (2015) Xing Liu et al. CYTOKINE & GROWTH FACTOR REVIEWS
- DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
- (2015) Anetta Härtlova et al. IMMUNITY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- Bruton’s Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response
- (2015) Koon-Guan Lee et al. Cell Reports
- Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
- (2014) Michael J. White et al. CELL
- Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
- (2014) Anthony Rongvaux et al. CELL
- The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling
- (2014) Qian Zhou et al. Cell Host & Microbe
- Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease
- (2014) Jeonghyun Ahn et al. CURRENT OPINION IN IMMUNOLOGY
- Role of DNA/RNA sensors and contribution to autoimmunity
- (2014) Siobhán Smith et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The mechanism of double-stranded DNA sensing through the cGAS-STING pathway
- (2014) Chang Shu et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Innate signaling in the inflammatory immune disorders
- (2014) Cheng Qian et al. CYTOKINE & GROWTH FACTOR REVIEWS
- IFI16: At the interphase between innate DNA sensing and genome regulation
- (2014) Martin R. Jakobsen et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
- (2014) Qiang Wang et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
- (2014) Seng-Ryong Woo et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- Adding to the STING
- (2014) Hong-Bing Shu et al. IMMUNITY
- NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING
- (2014) Lu Zhang et al. IMMUNITY
- Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
- (2014) Ivana Škrnjug et al. PLoS One
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
- (2014) Pu Gao et al. Cell Reports
- Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy
- (2014) Yuk Yuen Lan et al. Cell Reports
- RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms
- (2014) Yue Qin et al. PLoS Pathogens
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
- (2013) Hiroyasu Konno et al. CELL
- Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis
- (2013) Alexandre Sze et al. Cell Host & Microbe
- Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
- (2013) Xing Liu et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Species-specific detection of the antiviral small-molecule compound CMA by STING
- (2013) Taner Cavlar et al. EMBO JOURNAL
- Immune Sensing of DNA
- (2013) Søren R. Paludan et al. IMMUNITY
- Cytosolic Sensing of Viruses
- (2013) Delphine Goubau et al. IMMUNITY
- Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
- (2013) Qiang Ding et al. JOURNAL OF HEPATOLOGY
- Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
- (2013) J. Conlon et al. JOURNAL OF IMMUNOLOGY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
- (2013) J. Petrasek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- STING-dependent cytosolic DNA sensing pathways
- (2013) Glen N. Barber TRENDS IN IMMUNOLOGY
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
- (2013) Elie J. Diner et al. Cell Reports
- Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity
- (2012) Sayuri Nitta et al. HEPATOLOGY
- Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
- (2012) Alevtina Gall et al. IMMUNITY
- 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential
- (2012) Daniel Prantner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination
- (2012) Jing Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium
- (2012) Zhi-hui Chen et al. NATURE
- The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
- (2012) Kislay Parvatiyar et al. NATURE IMMUNOLOGY
- Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling
- (2012) Li Sun et al. PLoS One
- STING manifests self DNA-dependent inflammatory disease
- (2012) J. Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
- (2012) Y. Tanaka et al. Science Signaling
- Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
- (2012) Chia-Yi Yu et al. PLoS Pathogens
- DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
- (2012) Sebastian Aguirre et al. PLoS Pathogens
- Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
- (2011) Huihui Chen et al. CELL
- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
- (2011) Nagaraj Kerur et al. Cell Host & Microbe
- Immune Signaling by RIG-I-like Receptors
- (2011) Yueh-Ming Loo et al. IMMUNITY
- A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells
- (2011) Samantha R Furr et al. Journal of Neuroinflammation
- The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
- (2011) Zhiqiang Zhang et al. NATURE IMMUNOLOGY
- Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant
- (2011) Thomas Ebensen et al. VACCINE
- Innate Immune Sensing of DNA
- (2011) Shruti Sharma et al. PLoS Pathogens
- Cyclic di-nucleotides: new era for small molecules as adjuvants
- (2011) Rimma Libanova et al. Microbial Biotechnology
- The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
- (2010) Tetsuo Tsuchida et al. IMMUNITY
- DNA vaccines: an historical perspective and view to the future
- (2010) Margaret A. Liu IMMUNOLOGICAL REVIEWS
- The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation
- (2010) B. Zhong et al. JOURNAL OF IMMUNOLOGY
- DAI (DLM-1/ZBP1) as a Genetic Adjuvant for DNA Vaccines That Promotes Effective Antitumor CTL Immunity
- (2010) Alvaro Lladser et al. MOLECULAR THERAPY
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
- (2010) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- IFI16 is an innate immune sensor for intracellular DNA
- (2010) Leonie Unterholzner et al. NATURE IMMUNOLOGY
- c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
- (2010) J. J. Woodward et al. SCIENCE
- The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
- (2010) Wangxue Chen et al. VACCINE
- RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
- (2009) Yu-Hsin Chiu et al. CELL
- Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome
- (2009) Kate Schroder et al. CURRENT BIOLOGY
- Antiviral defense: RIG-Ing the immune system to STING
- (2009) J. Bradford Bowzard et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The roles of TLRs, RLRs and NLRs in pathogen recognition
- (2009) T. Kawai et al. INTERNATIONAL IMMUNOLOGY
- A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
- (2009) Sarah M. McWhirter et al. JOURNAL OF EXPERIMENTAL MEDICINE
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
- (2009) Teresa Fernandes-Alnemri et al. NATURE
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
- (2009) Veit Hornung et al. NATURE
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
- (2009) Andrea Ablasser et al. NATURE IMMUNOLOGY
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
- (2009) Tilmann Bürckstümmer et al. NATURE IMMUNOLOGY
- ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
- (2009) W. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
- (2008) Daniel B. Stetson et al. CELL
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- Pattern recognition receptors and control of adaptive immunity
- (2008) Noah W. Palm et al. IMMUNOLOGICAL REVIEWS
- RNA recognition and signal transduction by RIG-I-like receptors
- (2008) Mitsutoshi Yoneyama et al. IMMUNOLOGICAL REVIEWS
- MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals
- (2008) L. Jin et al. MOLECULAR AND CELLULAR BIOLOGY
- TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
- (2008) Ken J. Ishii et al. NATURE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
- (2008) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started