期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 26, 期 3, 页码 379-387出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.03.001
关键词
Ubiquitin; RIG-I; STING; Post-translational modification; Innate immunity
资金
- National Natural Science Foundation of China [31030021, 31300735, 81161120542]
- Ministry of Science and Technology of China [2012CB910200, 2011CB910904]
- Postdoctoral Research Program in Shanghai Institutes for Biological Sciences [2013KIP301]
- SASIBS Scholarship Program
Ubiquitin is a versatile molecular signature that modulates diverse cellular processes via proteasome-dependent and proteasome-independent mechanisms. The covalent and/or non-covalent binding of mono-ubiquitin and/or poly-ubiquitin chains to a target protein broadens the dynamic and functional spectra for signal integration. Different linkages of poly-ubiquitin chains determine specific physiological or pathological functions of target proteins. Accumulating evidences has revealed the essential roles of ubiquitination in orchestrating the host defenses against cytosolic RNA or DNA from viral infections. In this review, we summarize the current progress regarding the understanding of ubiquitin-mediated regulation of the RIG-I and STING antiviral signaling pathways and discuss certain critical issues that remain to be resolved in future studies. (C) 2015 Elsevier Ltd. All rights reserved.
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