Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A

Total synthesis of (–)-tubingensin B enabled by the strategic use of an aryne cyclization

(2017) Michael A. Corsello et al.   Nature Chemistry

Development of a Unique Class of Spiro-Type Two-Photon Functional Fluorescent Dyes and Their Applications for Sensing and Bioimaging

(2016) Hua Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Enantioselective Total Synthesis of (−)-Terengganensine A

(2016) Cyril Piemontesi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Strictamine

(2016) Weiwu Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus

(2016) Gui-Guang Cheng et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Total Synthesis of (+)-Hinckdentine A via a Catalytic Dearomatization Approach

(2016) Kazuya Douki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Aryl Ketoamides via Aryne Insertion into Imides

(2016) Austin C. Wright et al.   ORGANIC LETTERS

The Development of Aza-Pinacol and Aza-Semipinacol Rearrangements for the Synthesis of Nitrogen-Containing Molecules

(2016) Liansuo Zu et al.   SYNLETT

Speramides A–B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007

(2016) Yao-Wen Chang et al.   TETRAHEDRON LETTERS

An Enantioselective Total Synthesis of (−)-Isoschizogamine

(2015) Zhengren Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ervatamines A–I, Anti-inflammatory Monoterpenoid Indole Alkaloids with Diverse Skeletons from Ervatamia hainanensis

(2015) Dong-Bo Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

(2015) Zhengren Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A

(2014) Olivier Wagnières et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

(2013) Thomas Buyck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heteroannulation of arynes with N-aryl-α-aminoketones for the synthesis of unsymmetrical N-aryl-2,3-disubstituted indoles: an aryne twist of Bischler–Möhlau indole synthesis

(2013) Ala Bunescu et al.   CHEMICAL COMMUNICATIONS

Enantioselective Total Syntheses of Leuconolam–Leuconoxine–Mersicarpine Group Monoterpene Indole Alkaloids

(2013) Zhengren Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aryne Insertion Reactions Leading to Bioactive Fused Quinazolinones: Diastereoselective Total Synthesis of Cruciferane

(2013) Sagar D. Vaidya et al.   ORGANIC LETTERS

Assembly of indolo[1,2-c]quinazolines using ZnBr2-promoted domino hydroamination–cyclization

(2013) Min Xu et al.   TETRAHEDRON LETTERS

Arynes in Transition-Metal-Free Multicomponent Coupling Reactions

(2012) Sachin Suresh Bhojgude et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arynes and Cyclohexyne in Natural Product Synthesis

(2012) Christian M. Gampe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

(2012) Alan D. Borthwick   CHEMICAL REVIEWS

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Use of benzynes for the synthesis of heterocycles

(2012) Anton V. Dubrovskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed Sequential Ullmann N-Arylation and Aerobic Oxidative C–H Amination: A Convenient Route to Indolo[1,2-c]quinazoline Derivatives

(2012) Peng Sang et al.   ORGANIC LETTERS

Aryne Insertion Reactions into Carbon-Carbon σ-Bonds

(2012) Hiroto Yoshida et al.   SYNLETT

Reaction of arynes with amino acid esters

(2011) Kentaro Okuma et al.   CHEMICAL COMMUNICATIONS

Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging

(2011) Jae Hong Lee et al.   CHEMICAL COMMUNICATIONS

Synthesis ofN-Arylisatins by the Reaction of Arynes with Methyl 2-Oxo-2-(arylamino)acetates

(2011) Donald C. Rogness et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Acridines by the [4 + 2] Annulation of Arynes and 2-Aminoaryl Ketones

(2010) Donald C. Rogness et al.   JOURNAL OF ORGANIC CHEMISTRY

Cascade Nucleophilic Addition−Cyclic Michael Addition of Arynes and Phenols/Anilines Bearing Ortho α,β-Unsaturated Groups: Facile Synthesis of 9-Functionalized Xanthenes/Acridines

(2009) Xian Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Insertion of Benzene Rings into the Amide Bond: One-Step Synthesis of Acridines and Acridones from Aryl Amides

(2009) Didier G. Pintori et al.   ORGANIC LETTERS

Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates

(2009) Donald C. Rogness et al.   TETRAHEDRON LETTERS

Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation

(2008) Christopher D. Gilmore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First Total Synthesis of Hinckdentine A

(2008) Kazuhiro Higuchi et al.   ORGANIC LETTERS