The Development of Aza-Pinacol and Aza-Semipinacol Rearrangements for the Synthesis of Nitrogen-Containing Molecules

Although the widespread usage of aza-pinacol and aza-semipinacol rearrangements as synthetic methods has not been found, these synthetic transformations offer novel tactics for the preparation of nitrogen-containing heterocycles and natural alkaloids. Herein, we briefly discuss the most recent developments in this area and present our strategy based on aza-pinacol rearrangements for the synthesis of indolines and indolenines. 1 Introduction 2 Recently Developed Aza-Pinacol and Aza-Semipinacol Rearrangements 3 Indoline/Indolenine Synthesis Employing Aza-Pinacol Rearrangements as the Key Strategy 4 Conclusion