Article
Biochemistry & Molecular Biology
Zhi-Wen Liu, Min Song, Jun-Ya Wang, De-Zhi Wang, Biao Sun, Lei Shi, Ren-Wang Jiang, Min Ma, Xiao-Qi Zhang
Summary: Eight unprecedented monoterpenoid indole alkaloid (MIA) adducts and dimers, melofusinines A-H (1-8), and three undescribed melodinus-type MIA monomers, melofusinines I-K (9-11), were isolated from Melodinus fusiformis. Compounds 1 and 2 are hybrid indole alkaloids incorporating an aspidospermatan-type MIA with a monoterpenoid alkaloid unit. Compounds 3-8 are the first MIA dimers constructed through an aspidospermatan-type monomer and a rearranged melodinus-type monomer.
Article
Plant Sciences
Kun Jiang, Xiao Liu, Yu-Ming Liu, Li-Ning Wang, Ya-Ting Xiao, Feng-Chen Wu
Summary: Six new isoquinoline alkaloids were isolated from the roots of Fissistigma polyanthum, along with a new furanone and 13 known isoquinoline alkaloids. The structures of the new compounds were identified through spectroscopic analysis. Compounds 1 and 2 are rare oxalylfused dehydroaporphine alkaloids. Compound 12 exhibited the strongest dual-target activities on AChE inhibition and A beta aggregation inhibition among the compounds tested, while compounds 13 and 19 showed noticeable inhibitions of AChE and BChE along with antioxidant activities. The alkaloids from F. polyanthum have the potential to inhibit and prevent Alzheimer's disease through ChEs, beta-amyloid pathways, and antioxidant activity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Xin-Hua Gao, Pei-Qian Wu, Yao-Yue Fan, Bin Zhou, Jian-Min Yue
Summary: Seven complex monoterpenoid indole-quinoline and bisindole alkaloids, suadimins D-J (1-7), with previously unreported carbon-carbon linkages, were isolated and identified from the twigs and leaves of Melodinus suaveolens. Their structures were determined through a combination of diverse methods, with a focus on extensive spectroscopic data analysis and electric circular dichroism (ECD) calculations. The cytotoxicity of these compounds against three cancer cell lines was evaluated, and some showed moderate activities with IC50 values ranging from 2.4 to 8.0 μM.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Guanqun Zhan, Fuxin Zhang, Kailing Yang, Tao Yang, Ruixi Zhou, Xueqing Ma, Nan Wang, Zengjun Guo
Summary: A new compound and four known compounds were isolated from Alstonia scholaris. The new compound has a unique carbon skeleton and shows potential anti-inflammatory activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Yu-Jie Li, Juan Li, Lan Xie, Jun-Yu Zhou, Qiu-Xuan Li, Rui-Yuan Yang, Yan-Ping Liu, Yan-Hui Fu
Summary: A chemical study on Melodinus cochinchinensis led to the discovery of a new monoterpenoid indole alkaloid and seven known alkaloids. These compounds showed significant neuroprotective effects against cell death, demonstrating promising potential for neuroprotection.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Afsar Khan, Guiguang Cheng
Summary: The study identified 21 monoterpenoid indole alkaloids (MIAs) in MCTA, with aspidospermine- and quinolone-type alkaloids as major compounds. MCTA demonstrated significant anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK pathways in both in vitro and in vivo assessments.
Article
Chemistry, Applied
Jie Zhou, Si-Yu Du, Zhong-Ying Fang, Jin-Hong Feng
Summary: Melognine, a novel monoterpenoid indole alkaloid isolated from the stems of Melodinus fusiformis, possesses a unique ring system and exhibits significant cytotoxicity against human breast cancer cells BT549. The mechanism of action involves activation of caspase-3 and p53, as well as downregulation of Bcl-2 to induce apoptosis in BT549 cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Xi-Tao Yan, Jiang-Xian Chen, Zi-Xuan Wang, Rui-Qi Zhang, Jin-Yan Xie, Rong-Wei Kou, Hui-Fang Zhou, An-Ling Zhang, Min-Chang Wang, Yan-Xia Ding, Jin-Ming Gao
Summary: Nine new sesquiterpenes, hyperhubeins A-I (1-9), and 14 known analogues (10-23) were isolated from Hypericum hubeiense. Their structures and configurations were determined via various analysis techniques. The isolated compounds showed neuroprotective and anti-neuroinflammatory activities in vitro, and possible interactions with inducible nitric oxide synthase were predicted. Furthermore, compound 12 exhibited antineuroinflammatory activity by suppressing toll-like receptor-4 (TLR-4) expression and inhibiting nuclear factor-kappa-B (NF-κB) signaling.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Wenzhong Li, Yu Wang, Huijing Qi, Ran Shi, Jiazhu Li, Si Chen, Xin-Ming Xu, Wei-Li Wang
Summary: The metal-free cascade cyclization reaction offers an efficient and catalyst-free method for the one-pot synthesis of various isoindoloisoquinoline and benzoindolizinoindole derivatives, which can be further transformed into nitrogen-containing nine-membered ring compounds through Hofmann elimination with high yields. The resulting products with fused N-polycyclic skeletons are difficult to be synthesized using traditional methods and have wide applications in the pharmaceutical industry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Feng Wu, Yi Chen, Jie-Lin Yin, Cun-Hui Zhu, Yan Zhang, Ji-Kai Liu, Juan He
Summary: Two previously unknown monoterpene quinoline alkaloids, melotenucadines A and B, along with four known analogs, were isolated from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were determined using extensive MS and NMR spectroscopic methods, and the absolute configuration was established through ECD calculations. Melotenucadine B exhibited cytotoxicity against MCF-7 cells (IC50=27.3 μM).
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Physical
Yu-qi Li, Jing Cai, Jia-xin Cheng, Sheng-zhi Su, Toshihiro Akihisa, Wen-yuan Liu, Feng Feng, Jie Zhang
Summary: This study investigated the chemical constituents of Alstonia mairei and isolated twenty-four monoterpenoid indole alkaloids. Four new compounds were discovered. The structures of these compounds were characterized using various techniques. The cytotoxic activities of the isolated compounds were evaluated, and several compounds demonstrated potent inhibitory activities against A549 lung cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Rui Yang, Zeyu Zhou, Huanfeng Jiang, Toh-Seok Kam, Kai Chen, Zhiqiang Ma
Summary: The first asymmetric total synthesis of the monoterpenoid indole alkaloid arboduridine has been achieved. The synthesis involves several reactions to construct the complex structure and demonstrates a highly enantioselective synthetic strategy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hajicek, Vincenzo De Luca, Yang Qu
Summary: This study discovered and characterized vindolinine synthase, an enzyme that catalyzes an unusual redox-neutral reaction, leading to alkaloid diversity. This has important implications for understanding plant specialized metabolism and alkaloid synthesis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Chao Liu, Luc Van Meervelt, Vsevolod A. Peshkov, Erik V. Van der Eycken
Summary: A novel gold-catalyzed hydroarylation/Michael addition process has been developed for the efficient construction of benzazepinoindole polycyclic scaffolds from readily accessible multifunctional Ugi adducts. The developed methodology exhibits a broad substrate scope, excellent functional-group tolerance, and high yields of the target benzazepinoindoles.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Qi-Min Cui, Xiao-Yan Cui, Si-Fan Teng, Shu-Yue He, Ya-Ping Liu, Gui-Guang Cheng
Summary: This study investigated the phytochemical components in Melodinus axillaris, resulting in the identification of 14 indole alkaloids and 2 other compounds. One of the alkaloids, Melaxillarine, was found to have an unusual structure. Furthermore, several compounds were isolated from this plant for the first time, and their distribution and chemotaxonomic significance in the Melodinus genus were discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Chemistry, Medicinal
Ping -Xing Qi, Shuang-Shuang Liu, Peng Zhang, Yan-Qing Xie, Zhu-Ya Yang, Afsar Khan, Lu Liu
Summary: Gentiana scabra, used in traditional Chinese medicine for treating hepatitis, was found to lack its key component gentiopicroside in the decoction, indicating a need for quality control. Further investigation revealed two new compounds derived from gentiopicroside, which exhibited hepatoprotective activity similar to gentiopicroside.
Article
Chemistry, Medicinal
Rui Xia, Qian Zhou, Qi-Xiu Zhou, Yan-Qing Xie, Afsar Khan, Zhi-Hong Zhou, Xiao-Man Lv, Lu Liu
Summary: Two new benzophenanthridine alkaloids enantiomers (+/-)-zanthonitidumines A (1) and B (2), along with seven known analogues (3-9), were isolated from Zanthoxylum nitidium. Their structures were determined by extensive spectroscopic techniques and ECD data. Compound 2 showed the most significant inhibition of IL-6 generation and TNF-alpha release, indicating its potential as an anti-inflammatory agent.
Article
Biochemistry & Molecular Biology
Juntao Guo, Yihui Zhang, Jinjun Li, Feng Wu, Liting Luo
Summary: This study developed a pyrite-based photo-Fenton system using citric acid and simulated/natural sunlight, which could generate H2O2 in situ through enhanced activation of molecular oxygen, for the degradation of pollutants. The system showed high efficiency in degrading acetaminophen under both xenon lamp and natural sunlight irradiation.
Article
Engineering, Environmental
Yongrong Zou, Wenyu Wang, Hao Wang, Cong Pan, Jing Xu, Ivan P. Pozdnyakov, Feng Wu, Jinjun Li
Summary: Graphene oxide (GO) has gained significant attention as an adsorbent and catalyst. A study found that GO can rapidly degrade acetaminophen (APAP) under simulated sunlight and in real surface water. The interaction between GO and pharmaceuticals and personal care products (PPCPs) is influenced by the molecular structure of PPCPs.
Article
Engineering, Environmental
Yang Rong, Cong Pan, Kexin Song, Jong Chol Nam, Feng Wu, Zhixiong You, Zhengping Hao, Jinjun Li, Zhongshen Zhang
Summary: In this study, hydrophobic bamboo-derived porous graphitized carbons (BPGCs) were prepared and showed high adsorption capacities for toluene, cyclo-hexane, and ethanol under dry conditions. Their adsorption capacities remained high for toluene and cyclohexane even at 80% relative humidity, and the uptake of ethanol increased. BPGC also exhibited faster adsorption kinetics compared to activated carbon.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Yan Wang, Wenpei Feng, Jinjun Li, Zhixiong You
Summary: This study proposed a novel two-step route for the synthesis of NH2-MIL-53(Fe) and investigated its dye adsorption performance. NH2-MIL-53(Fe) exhibited high water stability in the pH range of 3-11 and showed significantly higher adsorption capacity and faster adsorption rate towards congo red. The maximum adsorption capacity of NH2-MIL-53(Fe) for congo red was 1877 mg center dot g(-1).
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Cong Pan, Wenyu Wang, Yihui Zhang, Jong Chol Nam, Feng Wu, Zhixiong You, Jing Xu, Jinjun Li
Summary: Wet scrubbing coupled with adsorption-enhanced heterogeneous advanced oxidation processes (AOPs) is a promising approach for treating chlorinated volatile organic compounds (CVOCs). Porous graphitized carbon (PGC) with a well-developed mesoporous structure is found to allow faster intra-particle diffusion of organic molecules. Therefore, a wet scrubbing system containing H2O2 and PGC-supported FeOCl catalyst has been developed and proven effective in removing gaseous CVOCs. Additionally, PGC-supported catalysts have shown potential as bifunctional adsorbent-catalyst materials for wet scrubbing of CVOCs.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Chemistry, Physical
Yushi Zhao, Jia Huang, Mingwei Yuan, Xiaozhong Li, Yan Wang, Mengwei Li, Jinjun Li, Zhixiong You
Summary: Anionic defects of H- ((HO)-O•) and oxygen vacancies with trapped electrons (V-O•) were introduced into the lattice of hydrothermally derived perovskite (Ba5Nb4O15) by CaH2 reduction. The anionic defects formed in CaH2-reduced BNO (CaBNO) were found to significantly enhance the ammonia synthesis activity of Ru/CaBNO by donating electrons to Ru atoms. The stoichiometry of H-O• and V-O• was determined by TPR and TPO methods, respectively. H-O• defects were proven to react with N-2 under ammonia synthesis conditions, providing secondary pathways for ammonia synthesis. Kinetic studies revealed that oxygen vacancies accept spilled-over H atoms from Ru particles to alleviate the H-2 poisoning effect. Cs promoter was shown to accelerate the formation of anionic defects in CaBNO under ammonia synthesis reactions.
Article
Green & Sustainable Science & Technology
Minjuan Cai, Peng Cheng, Jinjun Li, Feng Wu, Mohamed Sarakha, Gilles Mailhot, Marcello Brigante
Summary: In this study, nano zero-valent iron catalysts supported on graphitized carbon (GC-nZVI) were used to efficiently degrade BPA under neutral pH conditions. The catalyst showed a significant synergistic effect, increasing the degradation efficiency of BPA under both dark and UVA conditions.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Physical
Cong Pan, Wenyu Wang, Chenchong Fu, Jong Chol Nam, Feng Wu, Zhixiong You, Jing Xu, Jinjun Li
Summary: A wet scrubber utilizing FeOCl-loaded biomass-derived activated carbon has been developed for the efficient removal of chlorinated volatile organic compounds (CVOCs) from air. The system performs well at low pH and H2O2 concentrations, and can remove over 90% of various CVOCs. The study also proposes a degradation pathway for dichloroethane and suggests the potential for designing catalysts based on biomass structures for wet oxidation of CVOCs or other contaminants.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nutrition & Dietetics
Yuxu Chen, Zhiye Zhao, Yaxian Li, Shancheng Guo, Haiaolong Yin, Lei Tian, Guiguang Cheng, Ye Li
Summary: The study found that the extract of red rice seed coat has therapeutic effects on alcoholic liver disease (ALD). Red rice seed coat extract can improve ALD by repairing intestinal barrier damage and reducing liver endotoxin levels, making it a potential functional food for the prevention and treatment of ALD.
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Food Science & Technology
Yuan Xu, Liping Sun, Yongliang Zhuang, Ying Gu, Guiguang Cheng, Xuejing Fan, Yangyue Ding, Haotian Liu
Summary: This paper aims to study the impact of proteins' emulsifying and gelling properties on the functionality of emulsion gels, in order to improve the stability and bioavailability of embedded bioactive substances.
Article
Multidisciplinary Sciences
Qian Zhou, Qixiu Zhou, Rui Xia, Peng Zhang, Yanqing Xie, Zhuya Yang, Afsar Khan, Zhihong Zhou, Wenhong Tan, Lu Liu
Summary: This study aimed to explore the protective effect and mechanism of swertiamarin (STM) or its heat-transformed products (HTPS) on acetaminophen (APAP)-induced hepatotoxicity. The results showed that STM or HTPS could reduce APAP-induced apoptosis of L-O2 cells and markedly alleviate the liver injury induced by APAP. Interestingly, HTPS exhibited a better protective effect against APAP-induced hepatotoxicity than STM. Furthermore, STM or HTPS improved histological abnormalities, inhibited lipid peroxidation, reduced the level of inflammatory mediators, and modulated the defense system of Nrf-2 and NF-kappa B.
Article
Engineering, Environmental
Minjuan Cai, Jinjun Li, Feng Wu, Guillaume Voyard, Gilles Mailhot, Marcello Brigante
Summary: In this study, a composite of graphitized carbon and nZVI (GC-nZVI) was synthesized and applied for the degradation of bisphenol A (BPA) in water. The results showed that GC-nZVI can effectively degrade BPA in the presence of H2O2 and UVA radiation, demonstrating its potential for wastewater treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
