Article
Cell Biology
Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won-Ho Kim, Yong Chul Bae, Heeyoung Kang, Gu Seob Roh
Summary: Age-related microglial activation is associated with cognitive impairment. TonEBP plays important roles in age-related microglial activation and memory deficits. TonEBP haploinsufficiency reduces microglial activation, synaptic pruning, dendritic spine loss, and memory deficits in middle-aged and amyloid beta oligomer-treated mice. Additionally, TonEBP knockdown attenuates migration and phagocytosis in amyloid beta oligomer-treated BV2 cells.
Article
Neurosciences
Jenna N. Adams, Soyun Kim, Batool Rizvi, Mithra Sathishkumar, Lisa Taylor, Alyssa L. Harris, Abanoub Mikhail, David B. Keator, Liv McMillan, Michael A. Yassa
Summary: This study examined the relationship between functional connectivity (FC) within the entorhinal-hippocampal circuit, mnemonic discrimination, and amyloid-P (AP) pathology. The findings suggest that low object mnemonic discrimination performance is associated with increased FC between the anterior-lateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, which is related to AP pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination is not associated with altered FC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hakon Grydeland, Donatas Sederevicius, Yunpeng Wang, David Bartres-Faz, Lars Bertram, Valerija Dobricic, Sandra Duzel, Klaus P. Ebmeier, Ulman Lindenberger, Lars Nyberg, Sara Pudas, Claire E. Sexton, Cristina Sole-Padulles, Oystein Sorensen, Kristine B. Walhovd, Anders M. Fjell
Summary: This study found that poor sleep quality is associated with rapid decline in hippocampal microstructure and memory decay, especially in the presence of A beta accumulation. The results were not explained by genetic risk factors, suggesting that poor sleep efficiency may be a risk marker for AD.
Article
Clinical Neurology
Hakon Grydeland, Donatas Sederevicius, Yunpeng Wang, David Bartres-Faz, Lars Bertram, Valerija Dobricic, Sandra Duezel, Klaus P. Ebmeier, Ulman Lindenberger, Lars Nyberg, Sara Pudas, Claire E. Sexton, Cristina Sole-Padulles, Oystein Sorensen, Kristine B. Walhovd, Anders M. Fjell
Summary: The study found that poor sleep quality and low sleep efficiency were associated with a faster decline in hippocampal microstructure, especially in the presence of A beta accumulation. The decline in hippocampal integrity mediated the relationship between sleep efficiency and memory decay.
Article
Food Science & Technology
Leila Nazari, Somayeh Komaki, Iraj Salehi, Safoura Raoufi, Zoleikha Golipoor, Masoumeh Kourosh-Arami, Alireza Komaki
Summary: Oxidative stress is an important factor in the development of Alzheimer's disease (AD). This study found that lutein, a carotenoid with antioxidant properties, has protective effects on memory and learning. Lutein reduces oxidative stress, improves memory and learning, and shows potential as a therapeutic agent for the treatment and prevention of AD.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Neurosciences
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
Summary: The hippocampal formation is vulnerable to normal aging, and Long-Evans rats serve as a valuable model to study aging. This study found individual differences in spatial navigation and episodic-like memory abilities in aged rats, similar to age-related cognitive decline observed in humans. These findings suggest that aged Long-Evans rats can be used to explore the changes in cognitive function during aging.
Article
Behavioral Sciences
Zinaida I. Storozheva, Elena I. Zakharova, Andrey T. Proshin
Summary: This study aimed to evaluate the association of ChAT activity in the neocortex and hippocampus with spatial learning using the Morris water maze. The results suggest different roles of ChAT activity in different stages of memory formation. Further evaluation of other signaling pathways at these stages is recommended.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Nutrition & Dietetics
Yasuyuki Imai, Yurino Koseki, Makoto Hirano, Shin Nakamura
Summary: Alzheimer's disease is the most common form of dementia, affecting cognitive function and daily life. Research suggests that phycocyanin has neuroprotective effects, and oral administration of enzyme-digested phycocyanin can improve cognitive impairment in AD model mice.
Article
Neurosciences
Xi Chen, Kaitlin E. Cassady, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Summary: Studies suggest that tau deposition begins in the anterolateral entorhinal cortex during normal aging and is facilitated by the presence of beta-amyloid, potentially marking the onset of Alzheimer's disease. Higher tau deposition in the anterior-temporal memory network is associated with faster memory decline, especially in individuals with beta-amyloid. When all three tau measures are considered, only tau in the anterior-temporal region significantly predicts memory decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Neurosciences
Elizabeth Williams, Ashli Alex, Xi Wei Chin, Tara Spires-Jones, Szu-Han Wang
Summary: This study aimed to investigate whether cognitive training in mid-adulthood could improve subsequent cognition and reduce AD pathology in mice. The results showed that mid-adulthood cognitive training improved accuracy in AD mice and efficiency in all mice in the spatial task, but had no clear benefit on memory or amyloid pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Eliud Enrique Villarreal-Silva, Alejandro Rafael Gonzalez-Navarro, Rodolfo Amador Salazar-Ybarra, Oscar Quiroga-Garcia, Miguel Angel de Jesus Cruz-Elizondo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Jesus Alberto Morales-Gomez, Alejandro Quiroga-Garza, Rodrigo Enrique Elizondo-Omana, Angel Raymundo Martinez-Ponce de Leon, Santos Guzman-Lopez
Summary: In this study, a parameter-based Search Strategy Algorithm (SSA) was developed to analyze spatial learning and memory in young and aged rats. Compared to traditional methods, SSA was able to show significant differences in the learning process and identify differences in search strategies between young and aged rats.
TRANSLATIONAL NEUROSCIENCE
(2022)