An overview of peptide and peptoid foldamers in medicinal chemistry

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Induced Folding of Protein-Sized Foldameric β-Sandwich Models with Core β-Amino Acid Residues

(2015) Gábor Olajos et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Reversible and Highly Selective Inhibitor of the Proteasomal Ubiquitin Receptor Rpn13 Is Toxic to Multiple Myeloma Cells

(2015) Darci J. Trader et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose

(2015) Nagula Chandramouli et al.   Nature Chemistry

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

(2015) Valeria Azzarito et al.   Chemical Science

Direct Comparison of Linear and Macrocyclic Compound Libraries as a Source of Protein Ligands

(2015) Yu Gao et al.   ACS Combinatorial Science

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly

(2014) Katelyn M. Seither et al.   BIOCHEMICAL JOURNAL

Targeting DNA G-Quadruplexes with Helical Small Molecules

(2014) Sebastian Müller et al.   CHEMBIOCHEM

Anthropogenic reaction parameters – the missing link between chemical intuition and the available chemical space

(2014) György M. Keserű et al.   CHEMICAL SOCIETY REVIEWS

Continuous-Flow Solid-Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess

(2014) István M. Mándity et al.   ChemSusChem

Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

(2014) Chiara Cabrele et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

(2014) Chandradhish Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

(2014) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a Complex Formed by a Protein and a Helical Aromatic Oligoamide Foldamer at 2.1 Å Resolution

(2013) Jérémie Buratto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improved Efficacy of Fosmidomycin against Plasmodium and Mycobacterium Species by Combination with the Cell-Penetrating Peptide Octaarginine

(2013) Christof Sparr et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of Peptoid Ligands for Anti-Aquaporin 4 Antibodies

(2013) Bindu L. Raveendra et al.   CHEMISTRY & BIOLOGY

Effect of Helical Conformation and Side Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition

(2013) Yuki Imamura et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

(2013) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Foldameric α/β-Peptide Analogs of the β-Sheet-Forming Antiangiogenic Anginex: Structure and Bioactivity

(2013) Zsófia Hegedüs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein-like Tertiary Folding Behavior from Heterogeneous Backbones

(2013) Zachary E. Reinert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Introduction of Cyclically Constrained γ-Residues Stabilizes an α-Peptide Hairpin in Aqueous Solution

(2013) George A. Lengyel et al.   ORGANIC LETTERS

Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer

(2013) Kolla Rajasekhar et al.   ChemPlusChem

In Vivo Biodistribution and Small Animal PET of 64Cu-Labeled Antimicrobial Peptoids

(2012) Jiwon Seo et al.   BIOCONJUGATE CHEMISTRY

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

(2012) Kérya Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extending Foldamer Design beyond α-Helix Mimicry: α/β-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling

(2012) Holly S. Haase et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design Strategies for the Sequence-Based Mimicry of Side-Chain Display in Protein β-Sheets by α/β-Peptides

(2012) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

(2012) Valeria Azzarito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers

(2012) Lívia Fülöp et al.   PLoS One

Protein Side-Chain Translocation MutagenesisviaIncorporation of Peptoid Residues

(2011) Byoung-Chul Lee et al.   ACS Chemical Biology

Antibacterial Mechanism of Action of Arylamide Foldamers

(2011) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening

(2011) M. Muralidhar Reddy et al.   CELL

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

On the Mechanism of Eukaryotic Cell Penetration by α- and β-Oligoarginines - Targeting Infected Erythro­cytes

(2011) Faustin Kamena et al.   CHEMISTRY & BIODIVERSITY

Broad Distribution of Energetically Important Contacts across an Extended Protein Interface

(2011) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Design of a β-Peptide That Targets Transmembrane Helices

(2011) Scott J. Shandler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extraordinarily Robust Polyproline Type I Peptoid Helices Generatedviathe Incorporation of α-Chiral AromaticN-1-Naphthylethyl Side Chains

(2011) Joseph R. Stringer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular Internalization of Water-Soluble Helical Aromatic Amide Foldamers

(2010) Jone Iriondo-Alberdi et al.   CHEMBIOCHEM

Bridged β3-Peptide Inhibitors of p53-hDM2 Complexation: Correlation between Affinity and Cell Permeability

(2010) Arjel D. Bautista et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates

(2010) Jiyong Lee et al.   Nature Chemical Biology

Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly

(2010) István M. Mándity et al.   ORGANIC LETTERS

Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease

(2010) Carol Man Gao et al.   PLoS One

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Peptidic Foldamer Helices: A Stereochemical Patterning Approach

(2009) István M. Mándity et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

(2009) Erinna F. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Challenges in monoclonal antibody-based therapies

(2009) Haritha Samaranayake et al.   ANNALS OF MEDICINE

N-Acylpolyamine inhibitors of HDM2 and HDMX binding to p53

(2009) Ryo Hayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Highly Potent and Cellularly Active β-Peptidic Inhibitor of the p53/hDM2 Interaction

(2009) Martin Hintersteiner et al.   CHEMBIOCHEM

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers

(2009) Yuki Imamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Silico Improvement of β3-Peptide Inhibitors of p53•hDM2 and p53•hDMX

(2009) Julien Michel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems

(2009) Benjamin C. Gorske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

(2009) Sarah A. Fowler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A peptoid antagonist of VEGF Receptor 2 recognizes a ‘hotspot’ in the extracellular domain distinct from the hormone-binding site

(2008) D. Gomika Udugamasooriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

High-throughput evaluation of relative cell permeability between peptoids and peptides

(2008) Niclas C. Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide–peptoid hybrids

(2008) Asier Unciti-Broceta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle

(2008) Hyun-Suk Lim et al.   CHEMICAL COMMUNICATIONS

Dual Mechanism of Bacterial Lethality for a Cationic Sequence-Random Copolymer that Mimics Host-Defense Antimicrobial Peptides

(2008) Raquel F. Epand et al.   JOURNAL OF MOLECULAR BIOLOGY

A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

(2008) D. Gomika Udugamasooriya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA