Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

(2017) Sofia Tzimopoulou et al.   JOURNAL OF ALZHEIMERS DISEASE

PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

(2014) Daniele de Paula Faria et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Remyelinating strategies in multiple sclerosis

(2014) Felix Luessi et al.   Expert Review of Neurotherapeutics

Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study

(2014) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Graphical Method to Compare the in vivo Binding Potential of PET Radioligands in the Absence of a Reference Region: Application to [11C]PBR28 and [18F]PBR111 for TSPO Imaging

(2014) Qi Guo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kinetic Modeling of the Monoamine Oxidase B Radioligand [11C]SL25.1188 in Human Brain with High-Resolution Positron Emission Tomography

(2014) Pablo M Rusjan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain

(2014) Anjani K. Tiwari et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET

(2014) A. Colasanti et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using PET Imaging and the Radioligand 11C-PK11195

(2014) E. Rissanen et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

(2014) C. A. Parker et al.   JOURNAL OF NUCLEAR MEDICINE

Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study

(2014) Paolo Giannetti et al.   NEUROBIOLOGY OF DISEASE

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

(2014) Kazushiro Takata et al.   PLoS One

Quantitative imaging of neuroinflammation in human white matter: A positron emission tomography study with translocator protein 18 kDa radioligand, [18F]-FEPPA

(2014) Ivonne Suridjan et al.   SYNAPSE

Longitudinal positron emission tomography imaging for monitoring myelin repair in the spinal cord

(2013) Chunying Wu et al.   ANNALS OF NEUROLOGY

PET/MRI: a new technology in the field of molecular imaging

(2013) A. Afaq et al.   BRITISH MEDICAL BULLETIN

Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

(2013) Yingjuan Lu et al.   CLINICAL IMMUNOLOGY

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed

(2013) Jeroen Melief et al.   GLIA

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

(2013) Debora Giunti et al.   IMMUNOLOGY

Voxel-Based Imaging of Translocator Protein 18Kda (TSPO) in High-Resolution PET

(2013) Ji Hyun Ko et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immune Players in the CNS: The Astrocyte

(2013) Cathy J. Jensen et al.   Journal of Neuroimmune Pharmacology

Magnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain

(2013) Linda Chang et al.   Journal of Neuroimmune Pharmacology

Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

(2013) Q. Guo et al.   JOURNAL OF NUCLEAR MEDICINE

Central Nervous System Expression and PET Imaging of the Translocator Protein in Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

(2013) F. Mattner et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

(2013) Yoony YJ Gent et al.   ARTHRITIS RESEARCH & THERAPY

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

(2013) Diego Clemente et al.   Frontiers in Cellular Neuroscience

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes

(2012) Rui Chen et al.   CELL

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies

(2012) Maqsood Yaqub et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18 kDa Translocator Protein Radioligand [18F]DPA-714

(2012) G. Abourbeh et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Imaging Imidazoline-I2 Binding Sites in Porcine Brain Using 11C-BU99008

(2012) S. Kealey et al.   JOURNAL OF NUCLEAR MEDICINE

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

(2012) Jonas Hannestad et al.   NEUROIMAGE

Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence

(2012) Thomas Prasloski et al.   NEUROIMAGE

Increased PK11195 PET binding in the cortex of patients with MS correlates with disability

(2012) M. Politis et al.   NEUROLOGY

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

(2012) Robin J. Tyacke et al.   SYNAPSE

Implementation of an Absolute Brain $^{1}$H-MRS Quantification Method to Assess Different Tissue Alterations in Multiple Sclerosis

(2011) M. Bagory et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

[11C]DAC-PET for Noninvasively Monitoring Neuroinflammation and Immunosuppressive Therapy Efficacy in Rat Experimental Autoimmune Encephalomyelitis Model

(2011) Lin Xie et al.   Journal of Neuroimmune Pharmacology

Decreased microglial activation in MS patients treated with glatiramer acetate

(2011) John N. Ratchford et al.   JOURNAL OF NEUROLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study

(2011) Napapon Sailasuta et al.   Neuropsychiatric Disease and Treatment

Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole

(2010) Bruno Stankoff et al.   ANNALS OF NEUROLOGY

A novel PET marker for in vivo quantification of myelination

(2010) Chunying Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vivo imaging of neuroinflammation: a comparative study between [18F]PBR111, [11C]CLINME and [11C]PK11195 in an acute rodent model

(2010) Nadja Van Camp et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation

(2010) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

(2010) Unsong Oh et al.   Journal of Neuroimmune Pharmacology

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Characterization of PiB Binding to White Matter in Alzheimer Disease and Other Dementias

(2009) M. T. Fodero-Tavoletti et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: Preclinical characterisation in nonhuman primate

(2009) Wadad Saba et al.   SYNAPSE

Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions

(2008) Jacqueline T. Chen et al.   ANNALS OF NEUROLOGY

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

(2008) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Novel Reference Region Model Reveals Increased Microglial and Reduced Vascular Binding of 11C-(R)-PK11195 in Patients with Alzheimer's Disease

(2008) G. Tomasi et al.   JOURNAL OF NUCLEAR MEDICINE

The Use of MR Imaging as an Outcome Measure in Multiple Sclerosis Clinical Trials

(2008) Robert A. Bermel et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

(2008) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: Preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients

(2007) Ádám Vas et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES