Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials

Health impact assessment from building life cycles and trace metals in coarse particulate matter in urban office environments

(2018) Murnira Othman et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles

(2018) Caixia Guo et al.   ENVIRONMENTAL POLLUTION

Nitroblue tetrazolium (NBT) assay

(2018) Robert John Aitken   REPRODUCTIVE BIOMEDICINE ONLINE

Atmospheric size-resolved trace elements in a city affected by non-ferrous metal smelting: Indications of respiratory deposition and health risk

(2017) Yan Lyu et al.   ENVIRONMENTAL POLLUTION

The endoplasmic reticulum stress inducer thapsigargin enhances the toxicity of ZnO nanoparticles to macrophages and macrophage-endothelial co-culture

(2017) Gui Chen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Modulation of voltage-gated conductances of retinal horizontal cells by UV-excited TiO 2 nanoparticles

(2017) Xenia Meshik et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling

(2017) Xin Nie et al.   Nanomedicine-Nanotechnology Biology and Medicine

Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling

(2017) Caixia Guo et al.   Nanotoxicology

Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials

(2017) Glen M DeLoid et al.   Nature Protocols

Neurotoxicity of traffic-related air pollution

(2017) Lucio G. Costa et al.   NEUROTOXICOLOGY

A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop

(2017) Lin Tian et al.   Particle and Fibre Toxicology

Functional tumor imaging based on inorganic nanomaterials

(2017) Jiangfeng Du et al.   Science China-Chemistry

Reactive oxygen species trigger NF-κB-mediated NLRP3 inflammasome activation induced by zinc oxide nanoparticles in A549 cells

(2017) Xiao Liang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles

(2017) Jingga Morry et al.   Redox Biology

Green Toxicology: a strategy for sustainable chemical and material development

(2017) Sarah E. Crawford et al.   Environmental Sciences Europe

Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles

(2016) Jean-Pascal Piret et al.   ARCHIVES OF TOXICOLOGY

Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution

(2016) Rui Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effect assessment of engineered nanoparticles in solid media – Current insight and the way forward

(2016) Mónica J.B. Amorim et al.   ENVIRONMENTAL POLLUTION

Metal oxide nanoparticles interact with immune cells and activate different cellular responses

(2016) Rosana Simón-Vázquez et al.   International Journal of Nanomedicine

Inflammatory MAPK and NF-κB signaling pathways differentiated hepatitis potential of two agglomerated titanium dioxide particles

(2016) Jin Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

Proteomic approach to nanotoxicity

(2016) Magdalena Matysiak et al.   Journal of Proteomics

The cytotoxicity of oxidized multi-walled carbon nanotubes on macrophages

(2016) Man Luo et al.   Science China-Chemistry

Analytical methods for nano-bio interface interactions

(2016) Jing Wang et al.   Science China-Chemistry

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

(2016) Tu C. Le et al.   Small

Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials

(2016) Xiumei Jiang et al.   Small

From the Cover: Comparative Numerical Modeling of Inhaled Nanoparticle Deposition in Human and Rat Nasal Cavities

(2016) Jingliang Dong et al.   TOXICOLOGICAL SCIENCES

A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C

(2016) Haitao Yuan et al.   TOXICOLOGICAL SCIENCES

An integrative data mining approach to identifying adverse outcome pathway signatures

(2016) Noffisat O. Oki et al.   TOXICOLOGY

Making big sense from big data in toxicology by read-across

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration

(2016) Rui Chen et al.   Toxicology Research

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents

(2015) Rui Chen et al.   ACS Nano

ZnO Nanoparticles Impose a Panmetabolic Toxic Effect Along with Strong Necrosis, Inducing Activation of the Envelope Stress Response in Salmonella enterica Serovar Enteritidis

(2015) Sinisa Vidovic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Silver nanoparticles activate endoplasmic reticulum stress signaling pathway in cell and mouse models: The role in toxicity evaluation

(2015) Lingling Huo et al.   BIOMATERIALS

Subchronic Toxicity and Cardiovascular Responses in Spontaneously Hypertensive Rats after Exposure to Multiwalled Carbon Nanotubes by Intratracheal Instillation

(2015) Rui Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review

(2015) Manivannan Yegambaram et al.   Current Alzheimer Research

Particle doses in the pulmonary lobes of electronic and conventional cigarette users

(2015) Maurizio Manigrasso et al.   ENVIRONMENTAL POLLUTION

Olfactory deposition of inhaled nanoparticles in humans

(2015) Guilherme J. M. Garcia et al.   INHALATION TOXICOLOGY

Evaluation of Nanoparticles Emitted from Printers in a lean Chamber, a Copy Center and Office Rooms: ealth Risks of Indoor Air Quality

(2015) Xiaofei Shi et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

High-Content Screening for Assessing Nanomaterial Toxicity

(2015) Lingling Huo et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Synchrotron radiation techniques for nanotoxicology

(2015) Yu-Feng Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Comparative modeling of exposure to airborne nanoparticles released by consumer spray products

(2015) Christian Riebeling et al.   Nanotoxicology

Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells

(2015) Jun-Hyung Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating

(2015) Anna Huk et al.   Particle and Fibre Toxicology

Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line

(2015) Akhilesh Dubey et al.   PLoS One

Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure

(2015) Natalia D. Magnani et al.   TOXICOLOGICAL SCIENCES

Toxicity of copper oxide nanoparticles in lung epithelial cells exposed at the air–liquid interface compared with in vivo assessment

(2015) Xuefang Jing et al.   TOXICOLOGY IN VITRO

Cytotoxic effects of cytoplasmic-targeted and nuclear-targeted gold and silver nanoparticles in HSC-3 cells – A mechanistic study

(2015) Lauren A. Austin et al.   TOXICOLOGY IN VITRO

Reducing the cytotoxicity of ZnO nanoparticles by a pre-formed protein corona in a supplemented cell culture medium

(2015) Hong Yin et al.   RSC Advances

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

(2015) Lucian Farcal et al.   PLoS One

Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis

(2015) Sudjit Luanpitpong et al.   Oncotarget

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

(2014) Ruibin Li et al.   ACS Nano

Endoplasmic Reticulum Stress Induced by Zinc Oxide Nanoparticles Is an Earlier Biomarker for Nanotoxicological Evaluation

(2014) Rui Chen et al.   ACS Nano

Oxidative Potential and Inflammatory Impacts of Source Apportioned Ambient Air Pollution in Beijing

(2014) Qingyang Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Using physiologically based pharmacokinetic (PBPK) modeling for dietary risk assessment of titanium dioxide (TiO2) nanoparticles

(2014) Gerald Bachler et al.   Nanotoxicology

Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: implication for cytotoxicity

(2014) Xiumei Jiang et al.   Nanotoxicology

Polyhydroxylated Metallofullerenols Stimulate IL-1β Secretion of Macrophage through TLRs/MyD88/NF-κB Pathway and NLRP3Inflammasome Activation

(2014) Zhiyun Chen et al.   Small

Multiwall Carbon Nanotubes Directly Promote Fibroblast-Myofibroblast and Epithelial-Mesenchymal Transitions through the Activation of the TGF-β/Smad Signaling Pathway

(2014) Peng Wang et al.   Small

Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro

(2014) Zhangjian Chen et al.   TOXICOLOGY LETTERS

Effects of iron or manganese doping of ZnO nanoparticles on their dissolution, ROS generation and cytotoxicity

(2014) Hong Yin et al.   RSC Advances

Carbon nanodots from date molasses: new nanolights for the in vitro scavenging of reactive oxygen species

(2014) Bodhisatwa Das et al.   Journal of Materials Chemistry B

Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology

(2013) Chunying Chen et al.   CHEMICAL SOCIETY REVIEWS

Zinc oxide nanoparticles decrease the expression and activity of plasma membrane calcium ATPase, disrupt the intracellular calcium homeostasis in rat retinal ganglion cells

(2013) Dadong Guo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Direct exposure at the air-liquid interface: evaluation of anin vitroapproach for simulating inhalation of airborne substances

(2013) Jessica Rach et al.   JOURNAL OF APPLIED TOXICOLOGY

Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity

(2013) Liming Wang et al.   Nanoscale

Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

(2013) Zuzana Magdolenova et al.   Nanotoxicology

Label-free in vitro toxicity and uptake assessment of citrate stabilised gold nanoparticles in three cell lines

(2013) Melissa A Vetten et al.   Particle and Fibre Toxicology

Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells

(2013) Brandi N Snyder-Talkington et al.   Particle and Fibre Toxicology

Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway

(2013) Peng Wang et al.   Small

Silver Nanoparticle Exposure Attenuates the Viability of Rat Cerebellum Granule Cells through Apoptosis Coupled to Oxidative Stress

(2013) Nuoya Yin et al.   Small

Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells

(2013) Kathy C. Nguyen et al.   TOXICOLOGY

The role of the glutamatergic NMDA receptor in nanosilver-evoked neurotoxicity in primary cultures of cerebellar granule cells

(2013) Elżbieta Ziemińska et al.   TOXICOLOGY

Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation

(2013) Daoguang Wang et al.   TOXICOLOGY IN VITRO

Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: Effect of size, surface coating, and intracellular uptake

(2013) Raju Y. Prasad et al.   TOXICOLOGY IN VITRO

Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1

(2013) Xiumei Jiang et al.   TOXICOLOGY LETTERS

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Understanding the Toxicity of Carbon Nanotubes

(2012) Ying Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage

(2012) Alexandra Hudecová et al.   FOOD AND CHEMICAL TOXICOLOGY

Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust

(2012) Christopher J. Gordon et al.   INHALATION TOXICOLOGY

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

(2012) Moustapha Ouedraogo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea

(2012) A. Hudecova et al.   MUTAGENESIS

DNA damage of macrophages induced by metal nanoparticulates using an air–liquid interface exposure model

(2012) Jonathan Grigg et al.   Nanotoxicology

A Mixture of Anatase and Rutile TiO2 Nanoparticles induces Histamine Secretion in Mast Cells

(2012) Eric Y Chen et al.   Particle and Fibre Toxicology

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

Effects of Silver Nanoparticles on Primary Mixed Neural Cell Cultures: Uptake, Oxidative Stress and Acute Calcium Responses

(2012) Andrea Haase et al.   TOXICOLOGICAL SCIENCES

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways

(2011) Yang Li et al.   BIOMATERIALS

Numerical modelling of nanoparticle deposition in the nasal cavity and the tracheobronchial airway

(2011) Kiao Inthavong et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Repetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ cultures

(2011) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Carbon Nanotubes Induce Malignant Transformation and Tumorigenesis of Human Lung Epithelial Cells

(2011) Liying Wang et al.   NANO LETTERS

The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

(2011) Lili Zhang et al.   Nanotoxicology

Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes

(2011) Cuicui Ge et al.   Nanotoxicology

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

(2011) Stephan Hackenberg et al.   TOXICOLOGY IN VITRO

New methods for nanotoxicology: synchrotron radiation-based techniques

(2010) Bing Wang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes

(2010) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The U.S. Environmental Protection Agency Strategic Plan for Evaluating the Toxicity of Chemicals

(2010) Michael Firestone et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity

(2010) Raymond F Hamilton et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Intracellular distribution, geno- and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells

(2010) Stephan Hackenberg et al.   TOXICOLOGY LETTERS

Silver nanoparticles: Evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells

(2010) Stephan Hackenberg et al.   TOXICOLOGY LETTERS

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441

(2009) Chiara Uboldi et al.   Particle and Fibre Toxicology

A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles

(2009) Anke Lenz et al.   Particle and Fibre Toxicology

Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells

(2009) Baher Fahmy et al.   TOXICOLOGY IN VITRO

Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles

(2009) Chuan-Chin Huang et al.   TOXICOLOGY IN VITRO

PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes

(2009) Rasmus Foldbjerg et al.   TOXICOLOGY LETTERS

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons

(2008) Jingxia Zhao et al.   NEUROTOXICOLOGY

NANOTECHNOLOGY: Can High-Speed Tests Sort Out Which Nanomaterials Are Safe?

(2008) R. F. Service   SCIENCE

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY