Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling

A paradoxical response of the rat organism to long-term inhalation of silica-containing submicron (predominantly nanoscale) particles of a collected industrial aerosol at realistic exposure levels

(2017) Marina P. Sutunkova et al.   TOXICOLOGY

A Systematic Review of Reported Exposure to Engineered Nanomaterials

(2016) Maximilien Debia et al.   ANNALS OF OCCUPATIONAL HYGIENE

Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype

(2016) Cinzia Antognelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

(2016) Caixia Guo et al.   International Journal of Nanomedicine

In vitro comet and micronucleus assays do not predict morphological transforming effects of silica particles in Syrian Hamster Embryo cells

(2016) Christian Darne et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Super-oxidation of silicon nanoclusters: magnetism and reactive oxygen species at the surface

(2016) Sergey Lepeshkin et al.   Nanoscale

Long-term exposures to low doses of silver nanoparticles enhanced in vitro malignant cell transformation in non-tumorigenic BEAS-2B cells

(2016) Wun Hak Choo et al.   TOXICOLOGY IN VITRO

Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress

(2016) Chen Lin et al.   Scientific Reports

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation

(2016) Arnold J. Levine et al.   Cold Spring Harbor Perspectives in Medicine

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos

(2016) Hejing Hu et al.   Toxicology Research

DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles

(2016) Yang Zou et al.   PLoS One

miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1

(2015) Yun Wang et al.   ARCHIVES OF TOXICOLOGY

Aberrant Cytokinesis and Cell Fusion Result in Multinucleation in HepG2 Cells Exposed to Silica Nanoparticles

(2015) Yongbo Yu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Combined toxicity of amorphous silica nanoparticles and methylmercury to human lung epithelial cells

(2015) Yongbo Yu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Interaction of SiO2 nanoparticles with neuronal cells: Ionic mechanisms involved in the perturbation of calcium homeostasis

(2015) Alessandra Gilardino et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

(2015) Caixia Guo et al.   International Journal of Nanomedicine

Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells

(2015) Xu Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis

(2015) Youn-hee Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Malignant human cell transformation of Marcellus Shale gas drilling flow back water

(2015) Yixin Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line

(2015) Adeline Tarantini et al.   TOXICOLOGY IN VITRO

Comparison of Nanoparticle Exposures Between Fumed and Sol-gel Nano-silica Manufacturing Facilities

(2014) Sewan OH et al.   INDUSTRIAL HEALTH

Effectiveness of local injection of lentivirus-delivered stathmin1 and stathmin1 shRNA in human gastric cancer xenograft mouse

(2014) Javed Akhtar et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species

(2014) Yongbo Yu et al.   JOURNAL OF HAZARDOUS MATERIALS

Long-term exposures to low doses of titanium dioxide nanoparticles induce cell transformation, but not genotoxic damage in BEAS-2B cells

(2014) Gerard Vales et al.   Nanotoxicology

Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues

(2014) Prasad Kovvuru et al.   Nanotoxicology

Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes

(2014) Sudjit Luanpitpong et al.   Particle and Fibre Toxicology

Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations

(2014) Manzoor Ahmad Gatoo et al.   Biomed Research International

Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation

(2013) Zhongjun Du et al.   Cardiovascular Toxicology

Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells

(2013) Maqusood Ahamed   HUMAN & EXPERIMENTAL TOXICOLOGY

Assessment of Nanoparticle Exposure in Nanosilica Handling Process: Including Characteristics of Nanoparticles Leaking from a Vacuum Cleaner

(2013) Boowook KIM et al.   INDUSTRIAL HEALTH

Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1

(2013) Zhan Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Multinucleation and cell dysfunction induced by amorphous silica nanoparticles in an L-02 human hepatic cell line

(2013) Yang Li et al.   International Journal of Nanomedicine

The effect of zinc oxide nanoparticles on mouse spermatogenesis

(2013) Ali Reza Talebi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

NF-κB-Mediated Inflammation Leading to EMT via miR-200c Is Involved in Cell Transformation Induced By Cigarette Smoke Extract

(2013) Yue Zhao et al.   TOXICOLOGICAL SCIENCES

Nanoparticles: a review of particle toxicology following inhalation exposure

(2012) Shahnaz Bakand et al.   INHALATION TOXICOLOGY

In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis

(2012) Romualdo Benigni et al.   MUTAGENESIS

Risk assessment of engineered nanomaterials: a review of available data and approaches from a regulatory perspective

(2012) Danail R. Hristozov et al.   Nanotoxicology

In vitrotoxicity of amorphous silica nanoparticles in human colon carcinoma cells

(2012) Helge Gehrke et al.   Nanotoxicology

Mechanism of cellular uptake of genotoxic silica nanoparticles

(2012) Qingshan Mu et al.   Particle and Fibre Toxicology

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

(2012) Javed Ahmad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Relationship of pulmonary toxicity and carcinogenicity of fine and ultrafine granular dusts in a rat bioassay

(2011) Angelika Kolling et al.   INHALATION TOXICOLOGY

The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells

(2011) Chunmei Gong et al.   MOLECULAR BIOLOGY REPORTS

Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo

(2011) Lyudmila P. Sycheva et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

OECD Detailed Review Paper (DRP) number 31 on “Cell Transformation Assays for Detection of Chemical Carcinogens”: main results and conclusions

(2011) Paule Vasseur et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

(2011) Chiara Uboldi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Carbon Nanotubes Induce Malignant Transformation and Tumorigenesis of Human Lung Epithelial Cells

(2011) Liying Wang et al.   NANO LETTERS

Cytotoxicity and mitochondrial damage caused by silica nanoparticles

(2011) Lei Sun et al.   TOXICOLOGY IN VITRO

Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells

(2011) Yang Li et al.   TOXICOLOGY IN VITRO

Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-κB pathways

(2010) Xin Liu et al.   BIOMATERIALS

Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmidlacZgene mutation assay

(2010) Margriet V. D. Z. Park et al.   Nanotoxicology

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells

(2010) Ai Gao et al.   TOXICOLOGY LETTERS

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability

(2009) C.F.D. Rodrigues et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure

(2009) Shing Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B

(2009) Hyun-Jeong Eom et al.   TOXICOLOGY IN VITRO

Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model

(2008) Zhe Zhang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

(2008) W. Lilienblum et al.   ARCHIVES OF TOXICOLOGY

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

(2008) Jingbo Pi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube

(2008) Atsuya Takagi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Anchorage-Independent Growth of Pocket Protein-Deficient Murine Fibroblasts Requires Bypass of G2 Arrest and Can Be Accomplished by Expression of TBX2

(2008) T. L. Vormer et al.   MOLECULAR AND CELLULAR BIOLOGY

Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice

(2008) M CHOI et al.   TOXICOLOGY LETTERS