A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

(2015) Corbin G. Thompson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment

(2015) Qiang Zhang et al.   TOXICOLOGICAL SCIENCES

Cardioprotection against doxorubicin by metallothionein Is associated with preservation of mitochondrial biogenesis involving PGC-1α pathway

(2014) Jiabin Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

(2014) Melvin Andersen   ALTEX-Alternatives to Animal Experimentation

Towards tailored assays for cell-based approaches to toxicity testing

(2014) Gian Paolo Rossini   ALTEX-Alternatives to Animal Experimentation

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Regulation of mitochondrial biogenesis and PGC-1α under cellular stress

(2013) Tina Wenz   MITOCHONDRION

Dose-Response Modeling of Etoposide-Induced DNA Damage Response

(2013) Zhenhong Li et al.   TOXICOLOGICAL SCIENCES

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

(2013) Q. Zhang et al.   Open Biology

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death

(2012) Jingwei Chi et al.   PLoS One

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

(2012) James Hynes et al.   TOXICOLOGY IN VITRO

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

(2012) Sandra Coecke et al.   TOXICOLOGY IN VITRO

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death

(2011) Andrey V. Kuznetsov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial biogenesis and the development of diabetic retinopathy

(2011) Julia M. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures

(2011) Xiaoqian Yu et al.   TOXICOLOGY

PGC-1 Coactivators in Cardiac Development and Disease

(2010) Glenn C. Rowe et al.   CIRCULATION RESEARCH

The Future Use of in Vitro Data in Risk Assessment to Set Human Exposure Standards: Challenging Problems and Familiar Solutions

(2010) Kenny S. Crump et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass

(2010) Deise Raquel Barpe et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Attenuation of Doxorubicin-Induced Cardiomyopathy by Endothelin-Converting Enzyme-1 Ablation Through Prevention of Mitochondrial Biogenesis Impairment

(2010) Kazuya Miyagawa et al.   HYPERTENSION

Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing

(2010) Qiang Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Signaling Motifs and Weber's Law

(2009) James E. Ferrell   MOLECULAR CELL

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Transcriptional coactivators PGC-1  and PGC-l  control overlapping programs required for perinatal maturation of the heart

(2008) L. Lai et al.   GENES & DEVELOPMENT