Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Rob J. van der Geest, Luuk H. G. A. Hopman, Lourens F. H. J. Robbers, M. Louis Handoko, Robin Nijveldt, John P. Greenwood, Sven Plein, Pankaj Garg
Summary: LV hemodynamic assessment by LV blood flow kinetic energetics in STEMI patients shows a significant inverse association with adverse LV-remodeling. Late-diastolic LV blood flow kinetic energetics early after acute MI is independently associated with adverse LV-remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Article
Cell Biology
Ferhat Eyyupkoca, Karabekir Ercan, Emrullah Kiziltunc, Ilgin Burcu Ugurlu, Ajar Kocak, Nilnur Eyerci
Summary: Increasing evidence suggests that miRNA plays an important role in myocardial healing and ventricular remodeling after acute myocardial infarction (AMI). A study found that there are 8 miRNAs associated with adverse left ventricular remodeling in ST-elevated MI patients. Among them, 3 miRNAs show significant differences during the follow-up period, while the rest show differences during the acute phase of AMI. Further mechanistic studies are needed to understand the complex remodeling process after AMI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biology
Sabina Andreea Leanca, Daniela Crisu, Antoniu Octavian Petris, Irina Afrasanie, Antonia Genes, Alexandru Dan Costache, Dan Nicolae Tesloianu, Irina Iuliana Costache
Summary: Myocardial infarction is the most common cause of death and morbidity worldwide. It is mainly caused by thrombotic occlusion in the coronary circulation. Current therapies aim to restore coronary flow and counteract neurohormonal activation, but myocardial ischemia still leads to left ventricular remodeling and eventually heart failure.
Article
Cardiac & Cardiovascular Systems
Camilla Calvieri, Nicola Galea, Francesco Cilia, Giacomo Pambianchi, Giuseppe Mancuso, Domenico Filomena, Sara Cimino, Iacopo Carbone, Marco Francone, Luciano Agati, Carlo Catalano
Summary: CMR feature tracking analysis offers an accurate method to assess myocardial damage and early left ventricular (LV) remodeling. This study found that a loading dose of 500 mg aspirin before primary coronary angioplasty (pPCI) can reduce myocardial damage and adverse LV remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hadar Ben-Arzi, Arka Das, Christopher Kelly, Rob J. van der Geest, Sven Plein, Erica Dall'Armellina
Summary: This study investigated the longitudinal changes in intraventricular flow post-STEMI and its predictive relevance of long-term cardiac remodeling. The results showed that patients with reduced ejection fraction retained significantly higher systolic kinetic energy, while preserved ejection fraction patients had persistently higher peakE-wave kinetic energy throughout the study period.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Ke Shi, Hua-yan Xu, Yong He, Min Ma, Lu Zhang, Jun-long Wang, Xue-sheng Li, Chuan Fu, Hong Li, Bin Zhou, Xiao-yue Zhou, Zhi Yang, Ying-kun Guo, Zhi-gang Yang
Summary: This study aimed to assess inflammation in the remote myocardium post-myocardial infarction (MI) and its association with left ventricular (LV) remodeling using T2 mapping. The results found significant increases in remote T2 post-MI, indicating potential inflammatory response and pathological changes. Both animal and human experiments demonstrated remote myocardial alterations in T2, with variations in remote T2 independently associated with LV remodeling in patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Xiong Chang Lim, Chenyuan Huang, Siti Maryam J. M. Yatim, Suet Yen Chong, Sock Hwee Tan, Xiaoxun Yang, Caryn L. Heldt, Jodi Pedersen, Michael Talanker, Harshvardhan Modh, Matthias G. Wacker, Giorgia Pastorin, Siew Pang Chan, A. Mark Richards, Chris J. Charles, Mark Y. Chan, Jiong-Wei Wang
Summary: The association between LDL-EV hemostatic/fibrinolysis protein ratios and post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling was investigated. It was found that higher levels of SerpinC1 and VWF but lower levels of plasminogen in LDL-EVs were associated with reverse LV remodeling. The ratios of VWF:Plasminogen and SerpinC1:Plasminogen showed better predictive power for reverse LV remodeling than current standard plasma biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Giorgia Panichella, Andrea Barison, Silvia Maffei, Matteo Cameli, Stefano Coiro, Flavio D'Ascenzi, Carlo Di Mario, Riccardo Liga, Rossella Marcucci, Doralisa Morrone, Iacopo Olivotto, Isabella Tritto, Michele Emdin
Summary: Gender differences exist in the epidemiology, clinical features, and outcome of myocardial infarction, with women showing lower propensity to develop spherical geometry and left ventricular dysfunction after MI, attributed to various physiological factors including hormonal influences. Future studies should focus on clarifying these sex differences and potential therapeutic targets.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Chen, Jennifer Erley, Kai Muellerleile, Dennis Saering, Charlotte Jahnke, Ersin Cavus, Jan N. Schneider, Stefan Blankenberg, Gunnar K. Lund, Gerhard Adam, Enver Tahir, Martin Sinn
Summary: This study demonstrates the predictive value of contrast-enhanced and non-contrast mapping CMR techniques for the development of left ventricular (LV) remodeling following acute myocardial infarction (AMI), and may help define CMR endpoints in myocardial infarction trials.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maass, Juergen Konradi, Dennis Mehrkens, Simon Geissen, Felix S. Nettersheim, Simon Braumann, Erik Michaelsson, Richard J. Nies, Samuel Lee, Marie-Christin Redzinski, Vera B. M. Peters, Harshal N. Nemade, Philipp von Stein, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Martin Mollenhauer
Summary: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, and ischemic cardiomyopathy is becoming a leading reason for hospitalization in the western world. Neutrophils (PMN) play a key role in the inflammatory response of the ischemic myocardium, and the enzyme myeloperoxidase (MPO) expressed in PMN is an important mediator of their inflammatory capacities. Reducing PMN count and inhibiting MPO showed positive effects on scar formation and cardiac function in murine models of MI, suggesting that MPO could be a promising pharmacological target for preventing long-term morbidity after MI.
Article
Cardiac & Cardiovascular Systems
Yohei Hanajima, Noriaki Iwahashi, Jin Kirigaya, Mutsuo Horii, Yugo Minamimoto, Masaomi Gohbara, Takeru Abe, Kozo Okada, Yasushi Matsuzawa, Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi
Summary: This study aimed to investigate the effect of glycemic variability (GV), determined using a continuous glucose monitoring system (CGMS), on left ventricular reverse remodeling (LVRR) after ST-segment elevation myocardial infarction (STEMI). The study found that GV measured using CGMS could be a predictor of LVRR and LVRR was associated with the incidence of major adverse cardiovascular events (MACE).
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luyang Wang, Anning Du, Yan Lu, Yunxi Zhao, Ming Qiu, Zhenyang Su, Huanyu Shu, Hui Shen, Wei Sun, Xiangqing Kong
Summary: This study found that PI16 is upregulated after myocardial infarction and protects against cardiomyocyte apoptosis and left ventricular remodeling by inhibiting the Wnt3a-beta-catenin pathway through the downregulation of HDAC1 expression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cell Biology
Kyoko Komai, Nicholas K. Kawasaki, Jason K. Higa, Takashi Matsui
Summary: Ferroptosis is an iron-dependent form of regulated cell death characterized by dysfunction of the GPX4 antioxidant system. Inhibiting ferroptosis restores cardiac function and provides protection against I/R injury.
