Article
Oncology
Francesco De Sanctis, Alessia Lamolinara, Federico Boschi, Chiara Musiu, Simone Caligola, Rosalinda Trovato, Alessandra Fiore, Cristina Frusteri, Cristina Anselmi, Ornella Poffe, Tiziana Cestari, Stefania Cane, Silvia Sartoris, Rosalba Giugno, Giulia Del Rosario, Barbara Zappacosta, Francesco Del Pizzo, Matteo Fassan, Erica Dugnani, Lorenzo Piemonti, Emanuela Bottani, Ilaria Decimo, Salvatore Paiella, Roberto Salvia, Rita Teresa Lawlor, Vincenzo Corbo, Youngkyu Park, David A. Tuveson, Claudio Bassi, Aldo Scarpa, Manuela Iezzi, Stefano Ugel, Vincenzo Bronte
Summary: PDAC tumors exhibit strong immunosuppressive characteristics that limit the success of immunotherapy. Research shows that reprogramming the tumor microenvironment by intervening in RNS production can enhance the efficacy of immune-based treatments.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Sandra Tietscher, Johanna Wagner, Tobias Anzeneder, Claus Langwieder, Martin Rees, Bettina Sobottka, Natalie de Souza, Bernd Bodenmiller
Summary: Immune checkpoint therapy in breast cancer is limited to triple negative patients and shows rare long-term clinical benefit. This study explores the immune environments of human breast tumors with or without exhausted T cells, focusing on luminal subtypes. The presence of a PD-1(high) exhaustion-like T cell phenotype is associated with an inflammatory immune environment, increased myeloid cell activation, elevated immunomodulatory and cytokine signaling, accumulation of natural killer T cells, and altered spatial organization. PD-1 and CXCL13 expression on T cells, and MHC-I expression on tumor cells are distinguishing features between the immune environments.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Joonsu Han, Rimsha Bhatta, Yusheng Liu, Yang Bo, Hua Wang
Summary: This study reports a hydrogel-based immunotherapy that can recruit dendritic cells and activate T cells simultaneously, reshaping the immunosuppressive tumor microenvironment and amplifying the cytotoxic T lymphocyte response. The hydrogel holds great promise for treating poorly-immunogenic solid tumors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Chen, Yipeng Jin, Xinqiu Li, Peihua Zhang, Wanbing Pan, Di Zhang, Degui Lin, Wen Chen, Jiahao Lin
Summary: Tumor-derived total RNA (TdRNA) and cell lysate (TCL) are attractive alternative sources of antigens in antitumor immunotherapy. This study compared the immune responses elicited by TdRNA and TCL against breast cancer. Both TdRNA and TCL stimulated dendritic cell (DC) maturation and induced robust cellular immune responses, but TdRNA showed stronger immunoactivities in increasing T cell population through DC activation. TdRNA combined with paclitaxel (PTX) exhibited better antitumor efficacy and lower systemic toxicity compared to TCL.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ruikun Wang, Jingru Chen, Wei Wang, Zhuoqian Zhao, Haoran Wang, Shiyu Liu, Fan Li, Yajuan Wan, Jie Yin, Rui Wang, Yuanke Li, Cuizhu Zhang, Hongkai Zhang, Youjia Cao
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer with high resistance to immune therapy due to its immunosuppressive tumor microenvironment (TME). This study investigates the effect of CD40L-armed oncolytic herpes simplex virus-1 (oHSV-CD40L) on the tumor immune microenvironment and aims to prolong the survival of PDAC mouse model. The results demonstrate that intratumoral application of oHSV-CD40L effectively restricts tumor growth, increases mature dendritic cells (DCs), activates cytotoxic T cells, and reduces regulatory T cells, leading to prolonged survival in PDAC mice. This study may contribute to the development of oHSV-CD40L as a therapy for PDAC in combination with immune checkpoint blockade.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Sarah I. M. Sutherland, Xinsheng Ju, L. G. Horvath, Georgina J. Clark
Summary: Despite the success of using checkpoint inhibitors to reprim T cells to recognize tumors in certain malignancies, including melanoma, lung, and renal cell carcinoma, many tumors, such as prostate cancer, remain resistant to such treatment. DC-based immunotherapy, such as Sipuleucel-T, has shown improved overall survival in prostate cancer, but further research into DC vaccines has been limited. Understanding the immunosuppressive environment of prostate cancer and developing new vaccine strategies that can overcome this environment is essential for future success in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
S. P. Lau, L. Klaase, M. Vink, J. Dumas, K. Bezemer, A. van Krimpen, R. van der Breggen, L. V. Wismans, M. Doukas, W. de Koning, A. P. Stubbs, D. A. M. Mustafa, H. Vroman, R. Stadhouders, J. B. Nunes, C. Stingl, N. F. C. C. de Miranda, T. M. Luider, S. H. van der Burg, J. G. Aerts, C. H. J. van Eijck
Summary: This study demonstrates the feasibility and safety of using allogeneic lysated dendritic cell vaccine in patients with resected pancreatic ductal adenocarcinoma. The vaccine induces immune reactivity to PDAC expressed antigens and has the potential to prevent disease recurrence and progression.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Biology
Yuexin Wang, Hui Yang, Anna Jia, Yufei Wang, Qiuli Yang, Yingjie Dong, Yueru Hou, Yejin Cao, Lin Dong, Yujing Bi, Guangwei Liu
Summary: Dendritic cells (DCs) are important in anti-tumor immunity, and the mechanical sensor Piezo1 plays a role in regulating the differentiation of T(H)1 and T-reg cells in response to mechanical stiffness or inflammatory signals. Genetic deletion of Piezo1 in DCs inhibits T(H)1 cell generation and promotes T-reg cell development, leading to cancer growth. Mechanistically, Piezo1-deficient DCs regulate the secretion of cytokines TGF beta 1 and IL-12, affecting the activity of TGF beta R2-p-Smad3 and IL-12R beta 2-p-STAT4, and influencing the differentiation of T-reg and T(H)1 cells. Additionally, Piezo1 integrates metabolic and signaling pathways to orchestrate T(H)1 and T-reg lineage commitment through IL-12 and TGF beta 1 derived from DCs. Our studies provide critical insight into the role of DC-based mechanical regulation in directing T cell lineage commitment in tumor microenvironments.
Review
Immunology
Pengxiang Yang, Yong Peng, Yuan Feng, Zhuoying Xu, Panfeng Feng, Jie Cao, Ying Chen, Xiang Chen, Xingjian Cao, Yumin Yang, Jing Jie
Summary: Immune cell-derived extracellular vesicles (EVs) have unique characteristics and bioinspired applications, such as the ability to pass through blood-brain and blood-tumor barriers, and loading of various effector molecules. They play an important role in intercellular communication, while the mechanisms underlying their antitumor effects are still being explored.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Poonam R. Pandey, Ken H. Young, Dhiraj Kumar, Neeraj Jain
Summary: The tumor immune microenvironment (TIME) plays a crucial role in tumor growth and metastasis by influencing the balance of immune-suppressive and cytotoxic responses. RNA-based therapeutics targeting RNA regulators in the TIME show promise in cancer immunotherapy.
Article
Immunology
Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Linnan Zhu
Summary: This study revealed the antitumor effects and multifaceted killing mechanisms of CD4(+) TCR-Ts, indicating that MHC class I-restricted CD4(+) TCR-Ts could serve as potential adoptive T cell therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Summary: Single-cell RNA-seq offers the opportunity to improve the efficacy of T-cell based immunotherapy. The plate-based method developed by the authors for cytotoxic T cell profiling captures a higher number of transcripts and detects genes with increased dynamic range compared to droplet-based methods.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Peter K. Kim, Christopher J. Halbrook, Samuel A. Kerk, Megan Radyk, Stephanie Wisner, Daniel M. Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W. Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D. Welling, Li Zhang, Matthew R. Pratt, Kayvan R. Keshari, Haoqiang Ying, Costas A. Lyssiotis
Summary: The rewired metabolism in pancreatic ductal adenocarcinomas is sustained by cancer cells scavenging nutrients from the tumor microenvironment to maintain glycosylation precursor pools. Hyaluronic acid, a carbohydrate polymer in pancreatic tumors, can refuel the hexosamine biosynthetic pathway beyond its structural and signaling roles, providing energy for PDA metabolism.
Article
Immunology
Jiali Zhang, Ji Tao, Ruo-Nan Gao, Zhi-Yuan Wei, Yu-Shan He, Chun-Yan Ren, Qi-Chun Li, Yan-Shan Liu, Ke-Wei Wang, Gong Yang, Chengjia Qian, Jian-Huan Chen
Summary: The study evaluated the expression of major cytotoxic T-cell trafficking chemokines and associated microbiota profiles in CRC patients, finding increased expression of CXCL9, CXCL10, and CXCL11 in tumor tissues. The high expression of CXCL9 was associated with enhanced CD8(+) T-cell infiltration and improved survival. Interestingly, the microbiota in tumor tissues showed reduced diversity and an increase in oral bacteria, with differences in microbial composition between tumor and adjacent normal tissues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ingunn M. Stromnes, Ayaka Hulbert, Meagan R. Rollins, Ryan S. Basom, Jeffrey Delrow, Patrick Bonson, Adam L. Burrack, Sunil R. Hingorani, Philip D. Greenberg
Summary: This study investigates the role of immune checkpoints in mediating functional dysfunction of engineered T cells in pancreatic ductal adenocarcinoma (PDA). The findings suggest that blockade of PD-1 signaling alone is not enough to overcome the dysfunction of TCR engineered T cells in PDA. Contributions from both the differentiation pathways induced during the T cell engineering process and intratumoral suppressive mechanisms render engineered T cells dysfunctional.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Gastroenterology & Hepatology
Qian-Qian Li, Hong-Yu Li, Zhao-Hui Bai, Cyriac Abby Philips, Xiao-Zhong Guo, Xing-Shun Qi
GASTROENTEROLOGY REPORT
(2020)
Article
Medicine, General & Internal
Qian-Qian Li, Xiao-Zhong Guo, Hong-Yu Li, Xing-Shun Qi
WORLD JOURNAL OF CLINICAL CASES
(2020)
Review
Gastroenterology & Hepatology
Yanyan Wu, Hongyu Li, Xiaozhong Guo, Eric M. Yoshida, Nahum Mendez-Sanchez, Giovanni Battista Levi Sandri, Rolf Teschke, Fernando Gomes Romeiro, Akash Shukla, Xingshun Qi
HEPATOLOGY INTERNATIONAL
(2020)
Article
Oncology
Xu Liu, Xiaozhong Guo, Hongyu Li, Jiang Chen, Hao Han
Summary: This study demonstrated that the high expression of the KAI1 gene promotes ferroptosis in human PC cells primarily by affecting FPN and GPX4. Although KAI1-induced ferroptosis did not significantly inhibit the proliferation of PC cells.
MOLECULAR MEDICINE REPORTS
(2021)
Letter
Gastroenterology & Hepatology
Yanyan Wu, Zhuan Ma, Xiaozhong Guo, Hongy Li, Yufu Tang, Hao Meng, Hao Yu, Chengfei Peng, Guiyang Chu, Xinwei Wang, Yue Teng, Quanyu Zhang, Tianyi Zhu, Bing Wang, Zhenhua Tong, Haitao Zhao, Hui Lu, Xingshun Qi
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Review
Medicine, Research & Experimental
Menghua Zhu, Hongyu Li, Yanyan Wu, Yang An, Yuye Wang, Chun Ye, Dan Zhang, Rui Ma, Xuehan Wang, Xiaodong Shao, Xiaozhong Guo, Xingshun Qi
Summary: Brunner's gland hamartoma is a rare benign tumor of the small intestine with low risk of malignancy. Its clinical presentation is nonspecific, etiology is unclear, and treatment strategy needs further refinement.
ADVANCES IN THERAPY
(2021)
Review
Gastroenterology & Hepatology
Yue Yin, Hongyu Li, Ji Feng, Kexin Zheng, Eric Yoshida, Le Wang, Yanyan Wu, Xiaozhong Guo, Xiaodong Shao, Xingshun Qi
Summary: This study conducted a systematic review and meta-analysis to explore the prevalence and characteristics of cervical inlet patch (CIP). The results showed that CIP is common, especially when using narrow-band imaging. It is associated with acid-related symptoms and Barrett's esophagus.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Review
Health Care Sciences & Services
Yanyan Wu, Hongyu Li, Zhongheng Zhang, Wenhua Liang, Tiansong Zhang, Zhenhua Tong, Xiaozhong Guo, Xingshun Qi
Summary: Advanced age, male gender, comorbidities, increased levels of acute inflammation or organ damage indicators, and complications are associated with the risk of mortality in COVID-19 patients.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Letter
Gastroenterology & Hepatology
Yanyan Wu, Zhuang Ma, Xiaozhong Guo, Hongyu Li, Yufu Tang, Hao Meng, Hao Yu, Chengfei Peng, Guiyang Chu, Xinwe Wang, Yue Teng, Quanyu Zhang, Tiany Zhu, Bing Wang, Zhenhua Tong, Ruirui Feng, Haitao Zhao, Hui Lu, Xingshun Qi
ANNALS OF HEPATOLOGY
(2021)
Letter
Virology
Ruirui Feng, Bing Wang, Zhuang Ma, Xiaozhong Guo, Hongyu Li, Yufu Tang, Hao Meng, Hao Yu, Chengfei Peng, Guiyang Chu, Xinwei Wang, Yue Teng, Quanyu Zhang, Tianyi Zhu, Zhenhua Tong, Haitao Zhao, Hui Lu, Xingshun Qi
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Qianqian Li, Xiaozhong Guo, Ji Feng, Xiangbo Xu, Saurabh Chawla, Hongyu Li, Xingshun Qi
Summary: This study found that independent risk factors for ECVs include hepatitis C virus infection, previous EVL, platelet count, and the presence of esophageal varices needing treatment. Subgroup analyses revealed that the use of nonselective beta-blockers and EVNTs were independent risk factors for ECVs in patients with and without previous endoscopic variceal therapy, respectively.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Xiaoye Shi, Chunmei Wang, Fanjun Meng, Shaoze Ma, Guangqin Xu, Tingwei Liu, Xiaozhong Guo, Hongyu Li, Xingshun Qi
Summary: This study aimed to investigate the impact of insufficient doses of medications on the success of Helicobacter pylori (H. pylori) eradication in bismuth-containing quadruple therapy (BQT). The results showed that inadequate doses of proton pump inhibitors (PPIs) and antibiotics in the BQT regimen compromised the success of H. pylori eradication.
POSTGRADUATE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Xingshun Qi, Zhaohui Bai, Qiang Zhu, Gang Cheng, Yu Chen, Xiaowei Dang, Huiguo Ding, Juqiang Han, Lei Han, Yingli He, Fanpu Ji, Hongxu Jin, Bimin Li, Hongyu Li, Yiling Li, Zhiwei Li, Bang Liu, Fuquan Liu, Lei Liu, Su Lin, Dapeng Ma, Fanping Meng, Ruizhao Qi, Tianshu Ren, Lichun Shao, Shanhong Tang, Yufu Tang, Yue Teng, Chunhui Wang, Ran Wang, Yunhai Wu, Xiangbo Xu, Ling Yang, Jinqiu Yuan, Shanshan Yuan, Yida Yang, Qingchun Zhao, Wei Zhang, Yongping Yang, Xiaozhong Guo, Weifen Xie
Summary: This research developed evidence-based clinical practice guidance on the use of terlipressin for liver cirrhosis-related complications. It proposed 10 major guidance statements regarding the efficacy and safety of terlipressin in liver cirrhosis. Terlipressin was found to be beneficial for the management of acute variceal bleeding and hepatorenal syndrome, but further studies are needed to explore its potential effects in other complications.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Cong Gao, Xiaozhong Guo, Hongyu Li, Hongxin Chen, Zhenjiao Gao, Fei Gao, Xingshun Qi
Summary: Background: Small intestinal Dieulafoy's lesion (DL) is a rare and life-threatening cause of gastrointestinal bleeding. The diagnostic and treatment approaches for DL in the jejunum and ileum are not well established. This case report suggests that double-balloon enteroscopy (DBE) is an effective method for the diagnosis and treatment of small intestinal DL. The patient was successfully treated with hemostatic clips under DBE via the anal route, and there was no recurrence during the follow-up period.
TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Menghua Zhu, Hongyu Li, Chunhui Wang, Benqiang Yang, Xuehan Wang, Feifei Hou, Shengye Yang, Yuye Wang, Xiaozhong Guo, Xingshun Qi
Summary: Focal nodular hyperplasia (FNH) is a solid benign tumor of the liver, predominantly in young women. Correct diagnosis on imaging examinations is crucial for avoiding misdiagnosis and guiding clinical decisions.
DRUG DISCOVERIES AND THERAPEUTICS
(2021)