Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease

5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway

(2015) Mingyi Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hydroxymethylcytosine and demethylation of theγ-globingene promoter during erythroid differentiation

(2015) Maria Armila Ruiz et al.   Epigenetics

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases

(2015) Hiromi Yamazaki et al.   PATHOLOGY INTERNATIONAL

The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes

(2015) Elango Bhakkiyalakshmi et al.   PHARMACOLOGICAL RESEARCH

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

(2015) Walid T. Khaled et al.   Nature Communications

Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies

(2014) Susan P. Perrine et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The Effect and Side Effect of Hydroxyurea Therapy on Patients With β-Thalassemia: A Systematic Review to December 2012

(2014) Mehrnoush Kosaryan et al.   HEMOGLOBIN

Proteasome Inhibition Induces Both Antioxidant and Hb F Responses in Sickle Cell DiseaseViathe Nrf2 Pathway

(2014) Vinod Pullarkat et al.   HEMOGLOBIN

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

(2014) Amma Owusu-Ansah et al.   Frontiers of Medicine

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia

(2013) Suthat Fucharoen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy

(2013) Alexander J. Gill et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

New Insights into the Pathogenesis of Preeclampsia – The Role of Nrf2 Activators and their Potential Therapeutic Impact

(2013) N. Kweider et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model

(2013) M. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction

(2013) Lihong Shi et al.   NATURE MEDICINE

Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

(2013) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Regulation of Gγ-Globin Gene by ATF2 and Its Associated Proteins through the cAMP-Response Element

(2013) Li Liu et al.   PLoS One

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

(2013) D. E. Bauer et al.   SCIENCE

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient

(2013) Alisa Tubsuwan et al.   STEM CELLS

Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes

(2013) Ji Hye Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

(2013) S Sampurno et al.   Cell Death & Disease

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

A reduced curcuminoid analog as a novel inducer of fetal hemoglobin

(2012) Nattawara Chaneiam et al.   ANNALS OF HEMATOLOGY

Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells

(2012) E. R. Macari et al.   BLOOD

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

(2012) Flávia C. Costa et al.   PLoS Genetics

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

(2011) P. Palsamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

(2011) D. Lavelle et al.   BLOOD

Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice

(2011) S. E. Meiler et al.   BLOOD

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

(2011) E. R. Macari et al.   BLOOD

The multifunctional role of EKLF/KLF1 during erythropoiesis

(2011) M. Siatecka et al.   BLOOD

Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway

(2011) Valya Ramakrishnan et al.   BLOOD CELLS MOLECULES AND DISEASES

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

(2011) Inderdeep S. Kalra et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line

(2011) Sima Zein et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

(2011) Ana I. Rojo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults

(2011) A. E. Gallienne et al.   HAEMATOLOGICA

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

(2011) Winfred C Wang et al.   LANCET

Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic  -Type Globin Promoters in Differentiated Adult Erythroid Cells

(2011) S. Cui et al.   MOLECULAR AND CELLULAR BIOLOGY

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

(2011) Akira Uruno et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

(2011) V. G. Sankaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal globin expression is regulated by Friend of Prmt1

(2010) T. B. van Dijk et al.   BLOOD

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

(2010) E. Bianchi et al.   BLOOD

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

(2010) Joseph Borg et al.   NATURE GENETICS

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster

(2009) N. Solovieff et al.   BLOOD

cJun modulates Gγ-globin gene expression via an upstream cAMP response element

(2009) Sirisha Kodeboyina et al.   BLOOD CELLS MOLECULES AND DISEASES

Hydroxyurea Generates Nitric Oxide in Human Erythroid Cells: Mechanisms for γ-Globin Gene Activation

(2009) Tzu-Fang Lou et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Role of STAT3 and GATA-1 interactions in γ-globin gene expression

(2009) Xiao Yao et al.   EXPERIMENTAL HEMATOLOGY

Erythropoiesis: Model systems, molecular regulators, and developmental programs

(2009) Asterios S. Tsiftsoglou et al.   IUBMB LIFE

The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells

(2009) Bart Baan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors

(2009) Deidre A. Dalmas et al.   TOXICOLOGIC PATHOLOGY

Oxidative Stress and Oxidative Damage in Carcinogenesis

(2009) James E. Klaunig et al.   TOXICOLOGIC PATHOLOGY

Erythropoietin enhancement of rat pancreatic tumor cell proliferation requires the activation of ERK and JNK signals

(2008) Chhanda Bose et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mir-144 selectively regulates embryonic  -hemoglobin synthesis during primitive erythropoiesis

(2008) Y.-F. Fu et al.   BLOOD

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

(2008) Ryan Holland et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells

(2008) Laure A. Moutouh-de Parseval et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA