期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 311, 期 1-2, 页码 94-100出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.07.023
关键词
ATF2; ERK1/2; p38; Fibroblasts; Serum
资金
- Dutch Diabetes Research Foundation [2001.00.46]
- European Union [BM0602]
Growth factors activate ATF2 via sequential phosphorylation of Thr69 and Thr71, where the ATF2-Thr71-phosphorylation precedes the induction of ATF2-Thr69 + 71-phosphorylation. Here, we studied the mechanisms contributing to serum-induced two-step ATF2-phosphorylation in JNK 1,2-deficient embryonic fibroblasts. Using anion exchange chromatography, ERK1/2 and p38 were identified as ATF2-kinases in vitro. Inhibitor studies as well as nuclear localization experiments show that the sequential nuclear appearance of ERK1/2 and p38 determines the induction of ATF2-Thr71 and ATF2-Thr69 + 71 phosphorylation in response to serum. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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