Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging

(2016) Joseph M. Szulczewski et al.   Scientific Reports

Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field

(2016) Sui Seng Tee et al.   Scientific Reports

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

(2015) Sun-Mi Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Single voxel localization for dynamic hyperpolarized 13C MR spectroscopy

(2015) Albert P. Chen et al.   JOURNAL OF MAGNETIC RESONANCE

Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor

(2015) Renuka Sriram et al.   NMR IN BIOMEDICINE

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Miniaturization of NMR Systems: Desktop Spectrometers, Microcoil Spectroscopy, and “NMR on a Chip” for Chemistry, Biochemistry, and Industry

(2014) Sergey S. Zalesskiy et al.   CHEMICAL REVIEWS

Simultaneous Steady-state and Dynamic13C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells

(2014) Chendong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

(2014) GuemHee Baek et al.   Cell Reports

Chemistry and biochemistry of13C hyperpolarized magnetic resonance using dynamic nuclear polarization

(2013) Kayvan R. Keshari et al.   CHEMICAL SOCIETY REVIEWS

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

(2013) Tiago B Rodrigues et al.   NATURE MEDICINE

Metabolic Reprogramming and Validation of Hyperpolarized13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor

(2013) Kayvan R. Keshari et al.   PROSTATE

Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas

(2012) K. R. Keshari et al.   CANCER RESEARCH

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Increasing the Sensitivity of Magnetic Resonance Spectroscopy and Imaging

(2011) Andrew Webb   ANALYTICAL CHEMISTRY

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study

(2009) J Klawitter et al.   BRITISH JOURNAL OF CANCER

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

Rapid detection and profiling of cancer cells in fine-needle aspirates

(2009) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

(2008) Michael G. Kharas et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging

(2008) Peder E.Z. Larson et al.   JOURNAL OF MAGNETIC RESONANCE