期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep32846
关键词
-
资金
- NIH/NCI Cancer Center Support [P30 CA008748]
- NIH/NIBIB [R00 EB014328]
- Memorial Sloan Kettering's Center for Molecular Imaging and Nanotechnology (CMINT)
- Tow Foundation Fellowship Program
- American-Italian Cancer Foundation Resarch Fellowship Program
Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting C-13 nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice relaxation time (T-1) of the nucleus. Sampling of the signal also destroys polarization, resulting in a limited temporal ability to observe biologically interesting reactions. In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tesla (1T) is a simple and cost-effective method to increase T(1)s without sacrificing signal-to-noise. Biologically-relevant information may be obtained with a permanent magnet using enzyme solutions and in whole cells. Of significance, our findings indicate that changes in pyruvate metabolism can also be quantified in a xenograft model at this field strength.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据