Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

(2016) Anna Rautanen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New Definitions for Sepsis and Septic Shock

(2016) Edward Abraham   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

(2016) Manu Shankar-Hari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

What was old is new again: using the host response to diagnose infectious disease

(2015) Emily R Ko et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children

(2015) James J Gilchrist et al.   LANCET

Getting sepsis therapy right

(2015) R. S. Hotchkiss et al.   SCIENCE

A Functional Synonymous Coding Variant in theIL1RNGene Is Associated with Survival in Septic Shock

(2014) Nuala J. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies

(2014) Ngan H. Lyle et al.   Annals of the New York Academy of Sciences

Methylthioadenosine Reprograms Macrophage Activation through Adenosine Receptor Stimulation

(2014) Peter A. Keyel et al.   PLoS One

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

(2013) W. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

(2013) R. J. Langley et al.   Science Translational Medicine

Understanding Human Variation in Infectious Disease Susceptibility through Clinical and Cellular GWAS

(2013) Dennis C. Ko et al.   PLoS Pathogens

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice

(2012) Nancy M. Benight et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

INRICH: interval-based enrichment analysis for genome-wide association studies

(2012) Phil H. Lee et al.   BIOINFORMATICS

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Dynamics of a Cytokine Storm

(2012) Hao Hong Yiu et al.   PLoS One

Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway

(2012) Camille Mary et al.   PLoS One

Balancing resistance and infection tolerance through metabolic means

(2012) M. C. Chambers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

(2012) D. C. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Discriminative Value of Inflammatory Biomarkers for Suspected Sepsis

(2011) Ephraim L. Tsalik et al.   JOURNAL OF EMERGENCY MEDICINE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Molecular Classification of Thyroid Nodules Using High-Dimensionality Genomic Data

(2010) Darya Chudova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

A Genome-wide In Vitro Bacterial-Infection Screen Reveals Human Variation in the Host Response Associated with Inflammatory Disease

(2009) Dennis C. Ko et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multiplex PCR To Diagnose Bloodstream Infections in Patients Admitted from the Emergency Department with Sepsis

(2009) Ephraim L. Tsalik et al.   JOURNAL OF CLINICAL MICROBIOLOGY