Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies

Vasopressin Compared with Norepinephrine Augments the Decline of Plasma Cytokine Levels in Septic Shock

(2013) James A. Russell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Recombinant Human Activated Protein C for Adults with Septic Shock. A Randomized Controlled Trial

(2013) Djillali Annane et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Patients on Chronic Dialysis in the United States, 2005-2011

(2013) D. B. Nguyen et al.   CLINICAL INFECTIOUS DISEASES

Human Recombinant Lactoferrin for Sepsis

(2013) Russell McCulloh et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Evaluation of community-acquired sepsis by PIRO system in the emergency department

(2013) Yun-Xia Chen et al.   Internal and Emergency Medicine

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

The Predisposition, Infection, Response and Organ Failure (Piro) Sepsis Classification System: Results of Hospital Mortality Using a Novel Concept and Methodological Approach

(2013) Cristina Granja et al.   PLoS One

Cytokines and Signaling Molecules Predict Clinical Outcomes in Sepsis

(2013) Christopher D. Fjell et al.   PLoS One

The Potential for PCR Based Testing to Improve Diagnosis and Treatment of Sepsis

(2013) Ngan Lyle et al.   Current Infectious Disease Reports

Excess Deaths Associated With Tigecycline After Approval Based on Noninferiority Trials

(2012) P. Prasad et al.   CLINICAL INFECTIOUS DISEASES

Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

(2012) J. M. Dulhunty et al.   CLINICAL INFECTIOUS DISEASES

Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria

(2012) Peter M. C. Klein Klouwenberg et al.   INTENSIVE CARE MEDICINE

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

2012 and beyond: potential for the start of a second pre-antibiotic era?

(2012) P. C. Appelbaum   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Sepsis studies need new direction

(2012) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

The birth pangs of monoclonal antibody therapeutics

(2012) Lara Marks   mAbs

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stratifying Risk Factors for Multidrug-Resistant Pathogens in Hospitalized Patients Coming From the Community With Pneumonia

(2011) S. Aliberti et al.   CLINICAL INFECTIOUS DISEASES

Impact of previous antibiotic therapy on outcome of Gram-negative severe sepsis*

(2011) Michael T. Johnson et al.   CRITICAL CARE MEDICINE

Diabetes and Sepsis: Preclinical Findings and Clinical Relevance

(2011) P. Schuetz et al.   DIABETES CARE

The impact of diabetes on the pathogenesis of sepsis

(2011) G. C. K. W. Koh et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of Predisposition, Insult/Infection, Response, and Organ dysfunction, Acute Physiology And Chronic Health Evaluation II, and Mortality in Emergency Department Sepsis in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle

(2011) H. Bryant Nguyen et al.   JOURNAL OF CRITICAL CARE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Drug withdrawal sends critical care specialists back to basics

(2011) Asher Mullard   LANCET

Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues

(2011) B. J. Stoll et al.   PEDIATRICS

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Empiric Combination Antibiotic Therapy Is Associated with Improved Outcome against Sepsis Due to Gram-Negative Bacteria: a Retrospective Analysis

(2010) S. T. Micek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Etiology of Illness in Patients with Severe Sepsis Admitted to the Hospital from the Emergency Department

(2010) Alan C. Heffner et al.   CLINICAL INFECTIOUS DISEASES

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality*

(2010) John H. Boyd et al.   CRITICAL CARE MEDICINE

Conventional and molecular techniques for the early diagnosis of bacteraemia

(2010) Michela Paolucci et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The response of the host microcirculation to bacterial sepsis: does the pathogen matter?

(2010) Matthieu Legrand et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

Sepsis and Septic Shock: A History

(2009) Duane J. Funk et al.   CRITICAL CARE CLINICS

Predisposition, insult/infection, response, and organ dysfunction: A new model for staging severe sepsis

(2009) Francesca Rubulotta et al.   CRITICAL CARE MEDICINE

Hyperglycemia–related mortality in critically ill patients varies with admission diagnosis*

(2009) Mercedes Falciglia et al.   CRITICAL CARE MEDICINE

Enabling a systems biology approach to immunology: focus on innate immunity

(2009) Jennifer L. Gardy et al.   TRENDS IN IMMUNOLOGY

Global trends in emerging infectious diseases

(2008) Kate E. Jones et al.   NATURE

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

(2008) James A. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE